J Neurogastroenterol Motil.  2015 Jul;21(3):330-336. 10.5056/jnm15094.

Prokinetics in the Management of Functional Gastrointestinal Disorders

• Quigley EM

• KMID: 2433472
• DOI: http://doi.org/10.5056/jnm15094

Abstract

A variety of common and some not common gastrointestinal syndromes are thought to be based on impaired gut motility. For some, the role of motility is well defined, for others and the functional gastrointestinal disorders, in particular, the role of hypo- or dysmotility remains unclear. Over the years pharmacological and physiological laboratories have developed drugs which stimulate gut motility; many have been evaluated in motility and functional disorders with what can best be described as mixed results. Lack of receptor specificity and resultant expected and unexpected adverse events have led to the demise of some of these agents. Newer, more selective agents offer promise but the heterogeneity of the clinical disorders they target continues to pose a formidable challenge to drug development in this area.

Keyword

Constipation; Dyspepsia; Gastroparesis; Intestinal pseudo-obstruction; Irritable bowel syndrome

MeSH Terms

Constipation
Dyspepsia
Gastrointestinal Diseases*
Gastroparesis
Intestinal Pseudo-Obstruction
Irritable Bowel Syndrome
Population Characteristics
Sensitivity and Specificity