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Effects of a Low-Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyol Diet on Symptoms of Functional Abdominal Pain in Pediatric Patients

Abdou El Gendy YG, Abdel Wahed MA, Hassan Ragab MH, Mohsen Awad YM

Purpose: Recently, great interest has been focused on dietary fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) for the treatment of functional abdominal pain (FAP). Several meta-analyses, including those on the...
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Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Trial

Shin SY, Park S, Moon JM, Kim K, Kim JW, Chun J, Lee TH, Choi CH, TMRGotKSfNaM

  • KMID: 2534323
  • J Neurogastroenterol Motil.
  • 2022 Oct;28(4):642-654.
  • doi: 10.5056/jnm21202
Background/Aims We aim to evaluate the differences in the microbiome of responders and non-responders, as well as predict the response to probiotic therapy, based on fecal microbiome data in patients with...
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Type of Rectal Barostat Protocol Affects Classification of Hypersensitivity and Prediction of Symptom Severity in Irritable Bowel Syndrome

Josefsson A, Törnblom H, Simrén M

  • KMID: 2534322
  • J Neurogastroenterol Motil.
  • 2022 Oct;28(4):630-641.
  • doi: 10.5056/jnm21214
Background/Aims Visceral hypersensitivity is an important pathophysiologic mechanism in irritable bowel syndrome (IBS). We compared 2 barostat distension protocols and their ability to distinguish between IBS patients and healthy controls, identify...
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Infantile Colic and the Subsequent Development of the Irritable Bowel Syndrome

Kim JH, Lee SW, Kwon Y, Ha EK, An J, Cha HR, Jeong SJ, Han MY

  • KMID: 2534321
  • J Neurogastroenterol Motil.
  • 2022 Oct;28(4):618-629.
  • doi: 10.5056/jnm21181
Background/Aims Little is known about the association between infantile colic and the later onset of irritable bowel syndrome (IBS). Methods This study examined all 917 707 children who were born in Korea between...
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Bile Acid and Gut Microbiota in Irritable Bowel Syndrome

Min YW, Rezaie A, Pimentel M

  • KMID: 2534314
  • J Neurogastroenterol Motil.
  • 2022 Oct;28(4):549-561.
  • doi: 10.5056/jnm22129
Gut microbiota and their metabolites like bile acid (BA) have been investigated as causes of irritable bowel syndrome (IBS) symptoms. Primary BAs are synthesized and conjugated in the liver and released...
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The Role of Short Chain Fatty Acids in Irritable Bowel Syndrome

Jiang W, Wu J, Zhu S, Xin L, Yu C, Shen Z

  • KMID: 2534313
  • J Neurogastroenterol Motil.
  • 2022 Oct;28(4):540-548.
  • doi: 10.5056/jnm22093
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is characterized by abdominal pain and disordered bowel habits. The etiology of IBS is multifactorial, including abnormal gut-brain interactions, visceral...
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Risk Factors for Self-reported Irritable Bowel Syndrome With Prior Psychiatric Disorder: The Lifelines Cohort Study

Creed F

  • KMID: 2531218
  • J Neurogastroenterol Motil.
  • 2022 Jul;28(3):442-453.
  • doi: 10.5056/jnm21041
Background/Aims The role of psychiatric disorder in irritable bowel syndrome (IBS) is not clear. This study aims to assess whether individuals who have psychiatric disorder prior to IBS onset differ in...
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How to Implement the 3-Phase FODMAP Diet Into Gastroenterological Practice

Sultan N, Varney JE, Halmos EP, Biesiekierski JR, Yao CK, Muir JG, Gibson PR, Tuck CJ

  • KMID: 2531181
  • J Neurogastroenterol Motil.
  • 2022 Jul;28(3):343-356.
  • doi: 10.5056/jnm22035
Background/Aims The 3-phase fermentable oligo-, di-, mono-saccharides, and polyols (FODMAP) diet has shown a high level of efficacy in irritable bowel syndrome, largely based on dietitian delivered education. However, access to...
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Efficacy of a Restrictive Diet in Irritable Bowel Syndrome: A Systematic Review and Network Meta-analysis

Yu SJ, Lee HS, Gung HJ, Kim JS, Kim KB, Kwon YH, Kim JH, Koo HS, Shin HD, Jee SR, Lee HB, Kim J, Park HW, IBS Research Study Group of the Korean Society of Neurogastroenterology and Motility

Background/Aims: Dietary factors can aggravate the symptoms of irritable bowel syndrome (IBS). Many IBS patients try restrictive diets to relieve their symptoms, but the types of diets with an exacerbating...
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Enterochromaffin Cells–Gut Microbiota Crosstalk: Underpinning the Symptoms, Pathogenesis, and Pharmacotherapy in Disorders of Gut-Brain Interaction

Wei L, Singh R, Ghoshal UC

  • KMID: 2531182
  • J Neurogastroenterol Motil.
  • 2022 Jul;28(3):357-375.
  • doi: 10.5056/jnm22008
Disorders of gut-brain interaction (DGBIs) are common conditions in community and clinical practice. As specialized enteroendocrine cells, enterochromaffin (EC) cells produce up to 95% of total body serotonin and coordinate...
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Antispasmodics

Song KH

Antispasmodics are effective in reducing abdominal pain associated with visceral organs, bloating, and bowel habit changes and are commonly used as “on-demand therapy.” A relatively regular intake of antispasmodics may...
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A Randomized, Double-blinded, Placebocontrolled Study to Evaluate the Efficacy and Safety of DA-9701 (Motilitone) in Patients With Constipation-type Irritable Bowel Syndrome and Functional Dyspepsia Overlap: A Pilot Study

Lee JY, Kim N, Yoon H, Shin CM, Park YS, Lee DH

  • KMID: 2528041
  • J Neurogastroenterol Motil.
  • 2022 Apr;28(2):265-275.
  • doi: 10.5056/jnm20236
Background/Aims To assess the effects and safety of DA-9701 (Motilitone) in patients with constipation-type irritable bowel syndrome (IBS-C) which frequently accompany functional dyspepsia (FD). Methods FD and IBS-C were diagnosed based on the Rome...
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Clinical Trials of Probiotics in Patients With Irritable Bowel Syndrome: Some Points to Consider

Quigley EMM

Probiotic products in various formulations are widely used world-wide for a seemingly limitless range of indications––from health maintenance to the alleviation of common intestinal ailments and on to the prevention...
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Functional Neuroimaging in Irritable Bowel Syndrome: A Systematic Review Highlights Common Brain Alterations With Functional Movement Disorders

Nisticò V, Rossi RE, D’Arrigo AM, Priori A, Gambini O, Demartini B

  • KMID: 2528033
  • J Neurogastroenterol Motil.
  • 2022 Apr;28(2):185-203.
  • doi: 10.5056/jnm21079
Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by recurring abdominal pain and altered bowel habits without detectable organic causes. This study aims to provide a comprehensive...
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Pathophysiological Commonality Between Irritable Bowel Syndrome and Metabolic Syndrome: Role of Corticotropin-releasing Factor–Toll-like Receptor 4–Proinflammatory Cytokine Signaling

Nozu T, Okumura T

  • KMID: 2528032
  • J Neurogastroenterol Motil.
  • 2022 Apr;28(2):173-184.
  • doi: 10.5056/jnm21002
Irritable bowel syndrome (IBS) displays chronic abdominal pain with altered defecation. Most of the patients develop visceral hypersensitivity possibly resulting from impaired gut barrier and altered gut microbiota. We previously...
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Functional Gastrointestinal Disorders in Patients with Inflammatory Bowel Disease

Kim KO

With emerging more effective drugs, the therapeutic goal of inflammatory bowel disease (IBD) has progressed from clinical remission to mucosal healing. Although the inflammation could be controlled more effectively than...
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Sex and Gender Differences in Overlap Syndrome of Functional Gastrointestinal Disorder and Effect of Genetic Polymorphisms in South Korea: A Long-term Follow-up Study

Lee JY, Kim N, Park JH, Yu JE, Song YJ, Yoon JW, Lee DH

  • KMID: 2523793
  • J Neurogastroenterol Motil.
  • 2022 Jan;28(1):145-158.
  • doi: 10.5056/jnm21047
Background/Aims Overlap functional gastrointestinal disorder (FGID) is associated with more severe gastrointestinal symptoms and lower quality of life. The aim of this study is to evaluate clinical features of non-erosive reflux...
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An evaluation of dietary adequacy among patients with constipation-predominant irritable bowel syndrome in Malaysia

Shafiee NH, Razalli NH, Mokhtar NM, Tan E, Ali RAR

Background/Aims: Substantial proportions of patients with constipation-predominant irritable bowel syndrome (IBS-C) linked their symptoms with particular intake of foods. However, there is lack of current data regarding the intake among...
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Internet Survey of Japanese Patients With Chronic Constipation: Focus on Correlations Between Sleep Quality, Symptom Severity, and Quality of Life

Yamamoto S, Kawamura Y, Yamamoto K, Yamaguchi Y, Tamura Y, Izawa S, Nakagawa H, Wakita Y, Hijikata Y, Ebi M, Funaki Y, Ohashi W, Ogasawara N, Sasaki M, Maekawa M, Kasugai K

  • KMID: 2521164
  • J Neurogastroenterol Motil.
  • 2021 Oct;27(4):602-611.
  • doi: 10.5056/jnm20135
Background/Aims Chronic constipation and lifestyle factors can affect sleep quality. We evaluated the relationship between chronic constipation and sleep in the Japanese population. Methods This cross-sectional internet-based survey included 3000 subjects with constipation,...
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Perceived Gastrointestinal Symptoms and Association With Meals in a French Cohort of Patients With Irritable Bowel Syndrome

Melchior C, Fremaux S, Jouët P, Macaigne G, Raynaud JJ, Facon S, Iglicki F, Taes Y, Sabate JM

  • KMID: 2521158
  • J Neurogastroenterol Motil.
  • 2021 Oct;27(4):574-580.
  • doi: 10.5056/jnm20201
Background/Aims The aim of our study is to evaluate the association between meals and perceived gastrointestinal symptoms in real life in a French cohort of irritable bowel syndrome (IBS) patients. Methods This prospective...
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