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Gastrointestinal Dysfunction in Parkinson’s Disease: Neuro-Gastroenterology Perspectives on a Multifaceted Problem

Tan AH, Chuah KH, Beh YY, Schee JP, Mahadeva S, Lim SY

Patients with Parkinson’s disease (PD) face a multitude of gastrointestinal (GI) symptoms, including nausea, bloating, reduced bowel movements, and difficulties with defecation. These symptoms are common and may accumulate during...
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Effect of constipation on acute urinary retention following transrectal prostate biopsy

Sahin C, Sinanoglu O, Karaca Y, Yuksel A, Kucuk EV, Sarica K, Erdogan E

Purpose: To evaluate the possible effect of constipation on the acute urinary retention (AUR) after transrectal ultrasound-guided prostate biopsy (TRUS PB). Materials and Methods: A total of 1,167 patients with prostate-specific...
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Protein Kinase CK2 Modulates the Calcium Sensitivity of Type 3 Small-conductance Calcium-activated Potassium Channels in Colonic Platelet-derived Growth Factor Receptor Alpha-positive Cells From Streptozotocin-induced Diabetic Mice

Song NN, Huang X, Lu HL, Lu C, Chen J, Xu WX

  • KMID: 2541577
  • J Neurogastroenterol Motil.
  • 2023 Apr;29(2):250-261.
  • doi: 10.5056/jnm22052
Background/Aims The gastrointestinal symptom of diabetes mellitus, chronic constipation, seriously affects patients’ life. Whereas, the mechanism of chronic constipation is still ambiguous, resulting in a lack of effective therapies for this...
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Dyssynergic Defecation in Chronically Constipated Children in Korea

Bae SH

Purpose: Dyssynergic defecation (DSD) is one of the important causes of chronic constipation in children. We aimed to analyze the clinical features, diagnostic test results, and treatments for DSD in...
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Improvement of the intestinal epithelial barrier during laxative effects of phlorotannin in loperamide‑induced constipation of SD rats

 Kim J,  Song H, Choi Y, Jin Y,  Roh Y,  Seol A, Park S, Park J, Kang H,  Hwang D

Background: Disruptions of the intestinal epithelial barrier (IEB) are frequently observed in various digestive diseases, including irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). This study assessed the improvement...
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Disorders of Gut-Brain Interaction in a National Cohort of Children With Down Syndrome

Ciciora SL, Manickam K, Saps M

  • KMID: 2537944
  • J Neurogastroenterol Motil.
  • 2023 Jan;29(1):94-101.
  • doi: 10.5056/jnm22055
Background/Aims Disorders of brain-gut interaction (DGBIs) are present in adults and children around the world. Down syndrome (DS) is the most common chromosomal condition in humans. While DS has associations with...
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Prevalence and Risk Factors of Functional Gastrointestinal Disorders in Infants in Indonesia

Lestari LA, Rizal AN, Damayanti W, Wibowo Y, Ming C, Vandenplas Y

Purpose: Information regarding functional gastrointestinal disorders (FGIDs) in infants is currently lacking in Indonesia. This study aimed to describe the prevalence and risk factors of FGIDs in infants aged 6...
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Assessing Rectocele Depth and Its Association with Symptoms of Pelvic Floor Disorders Using 2D Transperineal Ultraound

Jeong HY, Lee JK

We investigated the clinical features of symptomatic rectoceles, as measured by transperineal ultrasound (TPUS), and evaluated the association between rectocele size and the clinical symptoms of pelvic floor disorders. This...
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Predicting Responsiveness to Biofeedback Therapy Using High-resolution Anorectal Manometry With Integrated Pressurized Volume

Seo M, Yoon J, Jung KW, Joo S, Lee J, Choi KM, Lee HJ, Yoon IJ, Noh W, Seo SY, Kim DY, Hwang SW, Park SH, Yang DH, Ye BD, Byeon JS, Yang SK, Myung SJ

  • KMID: 2534320
  • J Neurogastroenterol Motil.
  • 2022 Oct;28(4):608-617.
  • doi: 10.5056/jnm21137
Background/Aims Biofeedback therapy is widely used to treat patients with chronic constipation, especially those with dyssynergic defecation. Yet, the utility of high-resolution manometry with novel parameters in the prediction of biofeedback...
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Clinical Factors Affecting Constipation in Patients with Schizophrenia Taking Clozapine

Lee MJ, Kim SJ, Moon JJ, Jeon DW, Jung DU

Objectives: To investigate clinical factors affecting constipation in patients with schizophrenia taking clozapine. Methods: The participants were patients with schizophrenia taking clozapine and tested for the Therapeutic Drug Monitoring from September...
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Functional Constipation is Associated with a Decline in Word Recognition 2 Years Later in Community-Dwelling Older Adults: The Korean Frailty and Aging Cohort Study

Jang H, Kim S, Kim B, Kim M, Jung J, Won CW

Background: Consumption and cognitive impairment are the most common health problems among older adults. This study aimed to determine the effects of functional constipation on cognitive decline in community-dwelling older...
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Relationship between Depression and Constipation: Results from a Large Cross-sectional Study in Adults

Adibi P, Abdoli M, Daghaghzadeh H, Keshteli AH, Afshar H, Roohafza H, Esmaillzadeh A, Feizi A

Background/Aims: Accumulating evidence based on a few studies suggests a relationship between depression and functional constipation. This study examined whether depression is associated with a higher risk of functional constipation...
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Comparison of laxative effects of fermented soybeans (Cheonggukjang) containing toxins and biogenic amines against loperamide-induced constipation mouse model

Kim HR, Park IS, Park SB, Yang HJ, Jeong DY, Kim SY

BACKGROUND/OBJECTIVES: (Cheonggukjang) is a traditional fermented soybean paste with significant health-promoting effects. On the other hand, there have been insufficient studies on the safety and efficacy of (Cheonggukjang), which is...
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Saccharomyces boulardii and Lactulose for Childhood Functional Constipation: A Multicenter Randomized Controlled Trial

Lee KJ, Ryoo E, Lee YM, Yoon JM, Jang HJ, Choi SY, Choi YJ, Kim HJ, Chung JY, Shim JO

  • KMID: 2531219
  • J Neurogastroenterol Motil.
  • 2022 Jul;28(3):454-462.
  • doi: 10.5056/jnm21130
Background/Aims The effects of probiotics in children vary based on diseases and probiotic strains. We aim to investigate the effectiveness of Saccharomyces boulardii and lactulose for treating childhood functional constipation. Methods This open-label...
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Safety and Efficacy of Elobixibat, an Ileal Bile Acid Transporter Inhibitor, in Elderly Patients With Chronic Idiopathic Constipation According to Administration Time: Interim Analysis of Post-marketing Surveillance

Nakajima A, Fujimaki M, Arai Y, Emori K

  • KMID: 2531217
  • J Neurogastroenterol Motil.
  • 2022 Jul;28(3):431-441.
  • doi: 10.5056/jnm20263
Background/Aims Elobixibat, an ileal bile acid transporter (apical sodium-dependent bile acid transporter) inhibitor, was recently launched in Japan for the treatment of chronic idiopathic constipation. We conducted an interim analysis of...
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A Systematic Review of the Development and Psychometric Properties of Constipation-related Patient-reported Outcome Measures: Opportunities for Digital Health

Lee VV, Lau NY, Xi DJY, Truong ATL, Blasiak A, Siah KTH, Ho D

  • KMID: 2531183
  • J Neurogastroenterol Motil.
  • 2022 Jul;28(3):376-389.
  • doi: 10.5056/jnm22004
Background/Aims Constipation can be a chronic condition that impacts daily functioning and quality of life (QoL). To aid healthcare providers in accurately assessing patient symptoms and treatment outcomes, patient-related outcome measures...
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A Randomized, Double-blind, Active-controlled Exploratory Clinical Trial for the Evaluation of the Efficacy and Safety of Goodmorning S Granule® on Constipation

Ju M, Kim N, Shin CM, Park YS, Yoon H, Choi Y, Lee DH

Background/Aims: Constipation is a common gastrointestinal disease that reduces the quality of life and incurs considerable medical expenses. Bisacodyl and sodium docusate are generally used to treat constipation. This study...
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Association Between Insomnia and Constipation: A Multicenter Three-year Cross-sectional Study Using Shift Workers' Health Check-up Data

Yun BY, Sim J, Yoon JH, Kim SK

Background Although insomnia and constipation are highly prevalent worldwide, studies examining a possible association between them are lacking. We examined the relationship between insomnia and constipation in shift workers who have...
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Saudi Experts Consensus on Diagnosis and Management of Pediatric Functional Constipation

Alshehri DB, Sindi HH, AlMusalami IM, Rozi IH, Shagrani M, Kamal NM, Alahmadi NS, Alfuraikh SS, Vandenplas Y

Although functional gastrointestinal disorders (FGIDs) are very common in pediatric patients, there is a scarcity of published epidemiologic data, characteristics, and management patterns from Saudi Arabia, which is the 2nd...
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Hypnosis to Reduce Distress in Children Undergoing Anorectal Manometry: A Randomized Controlled Pilot Trial

Baaleman DF, Vriesman MH, Koppen IJN, Osborne KM, Benninga MA, Saps M, Yacob D, Lu PL, Woodley FW, Lorenzo CD

  • KMID: 2528046
  • J Neurogastroenterol Motil.
  • 2022 Apr;28(2):312-319.
  • doi: 10.5056/jnm20274
Background/Aims To assess the effectiveness and feasibility of a brief session of hypnosis to reduce distress in children with functional constipation undergoing anorectal manometry (ARM). Methods A partially-blinded randomized controlled pilot trial was conducted...
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