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Saudi Experts Consensus on Diagnosis and Management of Pediatric Functional Constipation

Alshehri DB, Sindi HH, AlMusalami IM, Rozi IH, Shagrani M, Kamal NM, Alahmadi NS, Alfuraikh SS, Vandenplas Y

Although functional gastrointestinal disorders (FGIDs) are very common in pediatric patients, there is a scarcity of published epidemiologic data, characteristics, and management patterns from Saudi Arabia, which is the 2nd...
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Hypnosis to Reduce Distress in Children Undergoing Anorectal Manometry: A Randomized Controlled Pilot Trial

Baaleman DF, Vriesman MH, Koppen IJN, Osborne KM, Benninga MA, Saps M, Yacob D, Lu PL, Woodley FW, Lorenzo CD

  • KMID: 2528046
  • J Neurogastroenterol Motil.
  • 2022 Apr;28(2):312-319.
  • doi: 10.5056/jnm20274
Background/Aims To assess the effectiveness and feasibility of a brief session of hypnosis to reduce distress in children with functional constipation undergoing anorectal manometry (ARM). Methods A partially-blinded randomized controlled pilot trial was conducted...
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A Randomized, Double-blinded, Placebocontrolled Study to Evaluate the Efficacy and Safety of DA-9701 (Motilitone) in Patients With Constipation-type Irritable Bowel Syndrome and Functional Dyspepsia Overlap: A Pilot Study

Lee JY, Kim N, Yoon H, Shin CM, Park YS, Lee DH

  • KMID: 2528041
  • J Neurogastroenterol Motil.
  • 2022 Apr;28(2):265-275.
  • doi: 10.5056/jnm20236
Background/Aims To assess the effects and safety of DA-9701 (Motilitone) in patients with constipation-type irritable bowel syndrome (IBS-C) which frequently accompany functional dyspepsia (FD). Methods FD and IBS-C were diagnosed based on the Rome...
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Overlap Between Constipation and Gastroesophageal Reflux Disease in Japan: Results From an Internet Survey

Ogasawara N, Funaki Y, Kasugai K, Ebi M, Tamura Y, Izawa S, Sasaki M

  • KMID: 2528044
  • J Neurogastroenterol Motil.
  • 2022 Apr;28(2):291-302.
  • doi: 10.5056/jnm21065
Background/Aims Detailed evaluations of overlapping constipation and gastroesophageal reflux disease (GERD) have not been conducted in Japan. The REACTION-J2 study examined the overlap of these diseases in Japan. Methods This internet-based survey recruited...
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Constipation is Associated With Mild Cognitive Impairment in Patients With de novo Parkinson’s Disease

Kang SH, Lee J, Koh SB

Objective The association between gastrointestinal (GI) symptoms and cognitive profile in patients with Parkinson’s disease (PD) at diagnosis remains unclear, although GI symptoms and cognitive impairment are highly prevalent in...
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The Advantages and Disadvantages of Prokinetics

Seo J, Jung KW

Prokinetics are medications that enhance gastrointestinal contractility; they improve the symptoms of patients with delayed gastrointestinal motility. Prokinetics have conventionally been used to stimulate gastrointestinal propulsion and to treat symptoms...
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Internet Survey of Japanese Patients With Chronic Constipation: Focus on Correlations Between Sleep Quality, Symptom Severity, and Quality of Life

Yamamoto S, Kawamura Y, Yamamoto K, Yamaguchi Y, Tamura Y, Izawa S, Nakagawa H, Wakita Y, Hijikata Y, Ebi M, Funaki Y, Ohashi W, Ogasawara N, Sasaki M, Maekawa M, Kasugai K

  • KMID: 2521164
  • J Neurogastroenterol Motil.
  • 2021 Oct;27(4):602-611.
  • doi: 10.5056/jnm20135
Background/Aims Chronic constipation and lifestyle factors can affect sleep quality. We evaluated the relationship between chronic constipation and sleep in the Japanese population. Methods This cross-sectional internet-based survey included 3000 subjects with constipation,...
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Medical Management of Constipation in Elderly Patients: Systematic Review

Kang SJ, Cho YS, Lee TH, Kim SE, Ryu HS, Kim JW, Park SY, Lee YJ, Shin JE, CRGotKSoNaM

  • KMID: 2521149
  • J Neurogastroenterol Motil.
  • 2021 Oct;27(4):495-512.
  • doi: 10.5056/jnm20210
Background/Aims Constipation is a common gastrointestinal problem in the elderly. Because of the limitations of life style modifications and the comorbidity, laxative use is also very common. Therefore, this study reviews...
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Safety/Efficacy of Prucalopride in Korean Patients with Chronic Constipation: Post-marketing Surveillance

Yeon SE, Kim SY, Chung WC, Jeon SW, Park SJ, Choi CH, Choi MG

Background/Aims: Constipation is a common gastrointestinal disorder. Prucalopride is a dihydrobenzofurancarboxamide derivative with gastrointestinal prokinetic activities and is recommended as an appropriate choice in patients unresponsive to laxatives. This study...
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Rectosigmoid Localization of Radiopaque Markers for Identifying Defecation Disorders in Patients With Chronic Constipation: A Retrospective Cohort Study

Abe T, Kunimoto M, Hachiro Y, Ohara K, Inagaki M, Murakami M

  • KMID: 2517536
  • J Neurogastroenterol Motil.
  • 2021 Jul;27(3):419-425.
  • doi: 10.5056/jnm20204
Background/Aims Defecation disorders (DD) are part of the spectrum of chronic constipation with outlet obstruction. Although anorectal physiologic tests are required for the diagnosis of DD, these tests are not available...
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Management of the Most Common Functional Gastrointestinal Disorders in Infancy: The Middle East Expert Consensus

Indrio F, Enninger A, Aldekhail W, Al-Ghanem G, Al-Hussaini A, Al-Hussaini B, Al-Refaee F, Al-Said K, Eid B, Faysal W, Hijazeen R, M.A. Isa H, Onkarappa D, Rawashdeh M, Rohani P, Sokhn M

The occurrence of functional gastrointestinal disorders (FGIDs) is a formidable challenge for infants, parents, and healthcare professionals. Although data from the Middle East are scarce, experts consider FGIDs a prevalent...
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Effects of Hand Press Pellet on Constipation in Patients with Breast Cancer Receiving Chemotherapy

Jung D, Park H

Purpose: The purpose of this study was to evaluate whether hand press pellet is effective for constipation in breast cancer patients receiving chemotherapy. Methods: This was a quasi-experimental study that used...
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Polyethylene Glycol Plus Electrolytes with Stimulant Laxative in Paediatric Faecal Disimpaction: A Randomised Controlled Study

Acharyya BC, Bhattacharyya C, Mukhopadhyay M, Acharyya S

Functional constipation is common in the paediatric population all over the world. Effective disimpaction to evacuate the impacted faecal matter forms an essential initial step in the management of constipation....
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Clinical and Radiologic Characteristics of Caudal Regression Syndrome in a 3-Year-Old Boy: Lessons from Overlooked Plain Radiographs

Kang S, Park H, Hong J

Caudal regression syndrome (CRS) is a rare neural tube defect that affects the terminal spinal segment, manifesting as neurological deficits and structural anomalies in the lower body. We report a...
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Effect of Physical Activity on the Association Between Dietary Fiber and Constipation: Evidence From the National Health and Nutrition Examination Survey 2005-2010

Li Y, Tong WD, Qian Y

  • KMID: 2510067
  • J Neurogastroenterol Motil.
  • 2021 Jan;27(1):97-107.
  • doi: 10.5056/jnm20051
Background/Aims The effect of physical activity on the relationship between dietary fiber intake and constipation has not been comprehensively studied. This study aims to explore the impact of physical activity. Methods Data were obtained...
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Prevalence of Defecation Disorders and their Symptoms is Comparable in Children and Young Adults: Cross-Sectional Study

Timmerman ME, Trzpis M, Broens PM

Purpose: We aimed to compare the prevalence rates and associated symptoms of constipation and fecal incontinence in children and young adults and evaluate how these patient groups cope with these...
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Clinical Evaluation of a Patient With Symptoms of Colonic or Anorectal Motility Disorders

Curtin B, Jimenez E, S CRao S

  • KMID: 2507107
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):423-436.
  • doi: 10.5056/jnm20012
Constipation, irritable bowel syndrome, fecal incontinence, abdominal pain, and anorectal pain are problems that affect 40% of the population. They commonly present with overlapping symptoms indicating that their pathophysiology affects...
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Prognostic Factors of Patients with Stercoral Perforation of the Colon

Lee HJ, Kim KH, Lee SC, Song S

Background/Aims: The incidence of stercoral perforation of the colon (SPC) is expected to rise, given the increased life expectancy and the aging population. On the other hand, the prognostic factors...
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CSP01, a Novel Superabsorbent Hydrogel, Reduces Colonic Transit Time in Patients With Chronic Idiopathic Constipation in a Randomized, Double-blind, Controlled Pilot Clinical Trial

Staller K, Barshop K, Vélez C, Bailey A, Locascio JJ, Chiquette E, Kuo B

  • KMID: 2507115
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):496-504.
  • doi: 10.5056/jnm20001
Background/Aims CSP01 is a novel superabsorbent hydrogel that absorbs gastrointestinal fluids and maintains high viscoelastic properties into the colon, where these fluids are released. Methods We conducted a single-center, randomized, double-blind, parallel-group, placebo-controlled...
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Analyzing the Role of Anal Sphincter Pressure in Rectocele Formation

Büyükaşık S, Bozkurt MA, Kapan S, Alis H

Purpose: Constipation is a common entity in society with various factors in the etiology. In this study, we evaluated the role of anal sphincter pressure of patients who refer to...
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