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Does the Oral-Anal Transit Test Correlate with Colonic Manometry Findings in Children with Refractory Constipation?

Dranove J, Fleishman , Reddy S, Teich S

PURPOSE: The Oral-anal Transit Test (OTT) is a simple method of obtaining information about colonic transit. We aim to assess the correlation of OTT with the neuromuscular integrity of the...
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Risk and Protective Factors for Gastrointestinal Symptoms associated with Antibiotic Treatment in Children: A Population Study

Baù M, Moretti A, Bertoni E, Vazzoler V, Luini C, Agosti M, Salvatore

PURPOSE: Gastrointestinal symptoms are often related to antibiotic treatment. Their incidence, risk and protective conditions in children are not well defined and represent the aims of this study. METHODS: We prospectively...
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Clinical Features of Severely Constipated Children: Comparison of Infrequent Bowel Movement and Fecal Soiling Groups

Lee G, Son JS, Bae SH

PURPOSE: To compare the clinical features, diagnostic findings, and medications of children with infrequent bowel movements or fecal soiling. METHODS: This study enrolled 333 children (189 male; age range, 1 month...
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Prostate Carcinosarcoma Developing After Combined Pelvic External Beam Radiation Therapy and Androgen Deprivation Therapy

Kim YJ

Carcinosarcoma of the prostate is a very rare disease, which consists of carcinomatous and sarcomatous components. The prognosis of patients with prostatic carcinosarcoma is poor. An 80-year-old man who had...
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Down the Rabbit Hole-Considerations for Ingested Foreign Bodies

Brown J, Kidder M, Fabbrini A, deVries J, Robertson , Chandler N, Wilsey M

We report the case of a seven-year-old boy with an ingested foreign body, which was retained within the appendix for a known duration of ten months, ultimately requiring appendectomy. The...
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Is fecal calprotectin always normal in children with irritable bowel syndrome?

Choi YJ, Jeong SJ

BACKGROUND/AIMS: Fecal calprotectin (FC) is a marker of intraluminal intestinal inflammation. Intestinal inflammation may contribute to the pathophysiology of irritable bowel syndrome (IBS). This study evaluated FC levels in children...
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Comparison of Delorme-Thiersch Operation Outcomes in Men and Women With Rectal Prolapse

Hyun K, Yoon SG

PURPOSE: The laparoscopic rectopexy has become increasingly popular with verified stability, surgical route selection should be tailored to individual patient characteristics rather than operative risk. The perineal approach is useful...
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Effects of Naloxegol on Gastrointestinal Transit and Colonic Fecal Volume in Healthy Participants Receiving Oxycodone

Olesen AE, Grønlund , Mark EB, Krogh K, Frøkjær , Drewes AM

  • KMID: 2460489
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):602-610.
  • doi: 10.5056/jnm18079
BACKGROUND/AIMS: Opioids cause gastrointestinal (GI) dysmotility, decrease gut secretion, and affect gut sphincters. Symptoms of opioid-induced bowel dysfunction may be alleviated by peripherally acting opioid antagonists like naloxegol, but detailed...
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A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation

Mori S, Tomita T, Fujimura K, Asano H, Ogawa T, Yamasaki T, Kondo T, Kono T, Tozawa K, Oshima T, Fukui H, Kimura T, Watari J, Miwa H

  • KMID: 2460486
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):563-575.
  • doi: 10.5056/jnm18194
BACKGROUND/AIMS: Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic...
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Is There a Need for Bowel Management after Surgery for Isolated Intestinal Malrotation in Children?

Salö M

PURPOSE: Few studies have reported non-acute long-term morbidity rates in children with intestinal malrotation. The aim of this study was to investigate the rate of constipation in children undergoing Ladd's...
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Metabolomics approach to serum biomarker for laxative effects of red Liriope platyphylla in loperamide-induced constipation of SD rats

Kim JE, Lee YJ, Ryu SH, Park JW, Kang MJ, Choi HJ, Bae SJ, Choi Y, Kang HG, Kim KB, Kim S, Lim Y, Hwang DY

Red Liriope platyphylla (RLP) is a known herbal medicine used in the treatment of some chronic diseases including constipation, neurodegenerative disorders, diabetes and obesity. To determine and characterize putative biomarkers...
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Bilateral Rotational S Flap Technique for Preventing Restenosis in Patients With Severe Circular Anal Stenosis: A Review of 2 Cases

Handaya Y, Sunardi M

Anal stenosis is a late hemorrhoidectomy complication. Sphincterotomy and various anoplasty techniques are used for treatment severe anal stenosis, such as the C flap, House flap, U flap, and rotational...
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Prescribing Opioids for Chronic Pain

Yoon DU, Kang UG

Opioids are effective analgesics, but they are often difficult to use properly, due mainly to adverse events, such as constipation, respiratory depression, addiction, tolerance, and opioid induced hyperalgesia. In the...
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Evaluation of symptoms and symptom combinations in histamine intolerance

Schnedl WJ, Lackner S, Enko D, Schenk M, Holasek SJ, Mangge H

BACKGROUND/AIMS: Food intolerance/malabsorption, particularly histamine intolerance (HIT), may cause nonspecific functional gastrointestinal and extraintestinal symptoms. We evaluated gastrointestinal and extraintestinal symptoms in patients with HIT. METHODS: In an analysis of outpatients'...
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Modulatory Effects of Gut Microbiota on Constipation: The Commercial Beverage Yakult Shapes Stool Consistency

Chen M, Ye X, Shen D, Ma C

  • KMID: 2454647
  • J Neurogastroenterol Motil.
  • 2019 Jul;25(3):475-477.
  • doi: 10.5056/jnm19048
No abstract available.
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Second Asian Consensus on Irritable Bowel Syndrome

Gwee KA, Gonlachanvit S, Ghoshal UC, Chua AS, Miwa H, Wu J, Bak YT, Lee OY, Lu CL, Park H, Chen M, Syam AF, Abraham P, Sollano J, Chang CS, Suzuki H, Fang X, Fukudo S, Choi MG, Hou X, Hongo M

  • KMID: 2454634
  • J Neurogastroenterol Motil.
  • 2019 Jul;25(3):343-362.
  • doi: 10.5056/jnm19041
BACKGROUND/AIMS: There has been major progress in our understanding of the irritable bowel syndrome (IBS), and novel treatment classes have emerged. The Rome IV guidelines were published in 2016 and...
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Synchronous Primary Leiomyosarcoma in the Thoracic Vertebra and the Liver

Kim YK, Kim JA, Ryu SH, Choi JH, Tsung PC, Park JH, Moon JS, Shim JC, Lee HK, Loutzenhiser JM

This is a case report of simultaneous primary leiomyosarcomas in the spine and liver. A 64-year-old woman presented to the Seoul Paik Hospital with epigastric discomfort and constipation that she...
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Coexistence of Excessive Weight Gain and Celiac Disease in Children: An Unusual Familial Condition

Calcaterra V, Regalbuto , Madè A, Magistrali M, Leonard MM, Cena H

Excessive weight gain in children diagnosed with celiac disease (CD) is becoming more common. We describe 2 siblings (9-year and 6 months-old female and 6-year and 9 months-old male) with...
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Nationwide Survey for Application of ROME IV Criteria and Clinical Practice for Functional Constipation in Children

Jang HJ, Chung JY, Seo JH, Moon JS, Choe BH, Shim JO

BACKGROUND: This study aimed to investigate the awareness and application of ROME IV criteria for functional constipation (FC) in real-world practices and assessed differences between pediatric gastroenterologists (PGs) and general...
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Nonmotor and Dopamine Transporter Change in REM Sleep Behavior Disorder by Olfactory Impairment

Lee JY, Yoon EJ, Kim YK, Shin CW, Nam H, Jeong JM, Kim HJ, Jeon B

OBJECTIVE: It is unclear whether the decline in dopamine transporters (DAT) differs among idiopathic rapid eye movement sleep behavior disorder (iRBD) patients with different levels of olfactory impairment. This study...
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