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Visceral Obesity as a Risk Factor for Left-Sided Diverticulitis in Japan: A Multicenter Retrospective Study

Yamada E, Ohkubo H, Higurashi , Sakai E, Endo H, Takahashi , Uchida E, Tanida E, Izumi N, Kanesaki A, Hata Y, Matsuura T, Fujisawa N, Komatsu K, Maeda S, Nakajima A

  • KMID: 1806669
  • Gut Liver.
  • 2013 Sep;7(5):532-538.
BACKGROUND/AIMS: Left-sided diverticulitis is increasing in Japan, and many studies report that left-sided diverticulitis is more likely to be severe. Therefore, it is important to identify the features and risk...
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Non-invasive imaging biomarkers for liver steatosis in non-alcoholic fatty liver disease: present and future

Nogami A, Yoneda M, Iwaki M, Kobayashi T, Honda Y, Ogawa Y, Imajo K, Saito S, Nakajima A

Non-alcoholic fatty liver disease is currently the most common chronic liver disease, affecting up to 25% of the global population. Simple fatty liver, in which fat is deposited in the...
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Endoscopic Interventions for the Early and Remission Phases of Acute Biliary Pancreatitis: What are the More Concrete and Practical Situations for Performing Them?

Hasegawa S, Koshita S, Kanno Y, Ogawa T, Sakai T, Kusunose H, Kubota K, Nakajima A, Noda Y, Ito K

Background/Aims: The use of endoscopic intervention (EI) for acute biliary pancreatitis (ABP) remains controversial because the severity of biliary obstruction/cholangitis/pancreatitis is not reflected in the indications for early EI (EEI). Methods:...
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Safety and Efficacy of Elobixibat, an Ileal Bile Acid Transporter Inhibitor, in Elderly Patients With Chronic Idiopathic Constipation According to Administration Time: Interim Analysis of Post-marketing Surveillance

Nakajima A, Fujimaki M, Arai Y, Emori K

  • KMID: 2531217
  • J Neurogastroenterol Motil.
  • 2022 Jul;28(3):431-441.
  • doi: 10.5056/jnm20263
Background/Aims Elobixibat, an ileal bile acid transporter (apical sodium-dependent bile acid transporter) inhibitor, was recently launched in Japan for the treatment of chronic idiopathic constipation. We conducted an interim analysis of...
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Clinical outcomes of permanent stenting with endoscopic ultrasound gallbladder drainage

Suzuki E, Fujita Y, Hosono K, Koyama Y, Tsujino S, Teratani T, Nakajima A, Matsuhashi N

Background/Aims: Endoscopic ultrasound gallbladder drainage (EUS-GBD) is gaining attention as a treatment method for cholecystitis. However, only a few studies have assessed the outcomes of permanent stenting with EUS-GBD. Therefore,...
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Anti-dementia Activity of Nobiletin, a Citrus Flavonoid: A Review of Animal Studies

Nakajima A, Ohizumi Y, Yamada K

  • KMID: 2279939
  • Clin Psychopharmacol Neurosci.
  • 2014 Aug;12(2):75-82.
Alzheimer's disease (AD), the most common form of dementia among the elderly, is characterized by the progressive decline of cognitive function and has a detrimental impact worldwide. Despite intensive laboratory...
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Neural Mechanisms of Discogenic Back Pain: How Does Nerve Growth Factor Play a Key Role?

Aoki Y, Ohtori S, Nakagawa K, Nakajima A, Inoue G, Miyagi M, Takahashi

It was reported that nerve fibers were present in the inner part of lumbar intervertebral discs from patients with discogenic pain. Because there are no nerve fibers in the inner...
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Feasibility of Endoscopic Papillary Large Balloon Dilation in Patients with Difficult Bile Duct Stones without Dilatation of the Lower Part of the Extrahepatic Bile Duct

Fujita Y, Iwasaki A, Sato T, Fujisawa T, Sekino Y, Hosono K, Matsuhashi N, Sakamaki K, Nakajima A, Kubota K

BACKGROUND/AIMS: There is no consensus for using endoscopic papillary large balloon dilation (EPLBD) in patients without dilatation of the lower part of the bile duct (DLBD). We evaluated the feasibility...
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Comparative Study of 2 Different Questionnaires in Japanese Patients: The Quality of Life and Utility Evaluation Survey Technology Questionnaire (QUEST) Versus the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease Questionnaire (FSSG)

Nonaka T, Kessoku T, Ogawa Y, Yanagisawa S, Shiba T, Sakaguchi , Atsukawa K, Takahashi , Sekino Y, Iida H, Endo H, Sakamoto Y, Koide T, Takahashi , Yoneda M, Maeda S, Nakajima A, Gotoh E, Inamori M

  • KMID: 2325972
  • J Neurogastroenterol Motil.
  • 2013 Jan;19(1):54-60.
BACKGROUND/AIMS: The aim of this study was to examine the convenience of the quality of life and utility evaluation survey technology (QUEST) questionnaire and the frequency scale for the symptoms...
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Change of Gastric Emptying With Chewing Gum: Evaluation Using a Continuous Real-Time 13C Breath Test (BreathID System)

Sakamoto Y, Kato S, Sekino Y, Sakai E, Uchiyama T, Iida H, Hosono K, Endo H, Fujita K, Koide T, Takahashi , Yoneda M, Tokoro C, Goto A, Abe Y, Kobayashi , Kubota K, Maeda S, Nakajima A, Inamori M

  • KMID: 2326212
  • J Neurogastroenterol Motil.
  • 2011 Apr;17(2):174-179.
BACKGROUND/AIMS: There are few reports on the correlation between chewing gum and the gastrointestinal functions. But previous report showed use of chewing gum to be an effective method for controlling...
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Mosapride Accelerates the Delayed Gastric Emptying of High-Viscosity Liquids: A Crossover Study Using Continuous Real-Time 13C Breath Test (BreathID System)

Sakamoto Y, Sekino Y, Yamada E, Ohkubo H, Higurashi , Sakai E, Iida H, Hosono K, Endo H, Nonaka T, Ikeda T, Fujita K, Yoneda M, Koide T, Takahashi , Goto A, Abe Y, Gotoh E, Maeda S, Nakajima A, Inamori M

  • KMID: 2325841
  • J Neurogastroenterol Motil.
  • 2011 Oct;17(4):395-401.
BACKGROUND/AIMS: The administration of liquid nutrients to patients is often accompanied by complications such as gastroesophageal reflux. To prevent gastroesophageal reflux, high-viscosity liquid meals are used widely, however, it still...
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Advanced fibrosis leads to overestimation of steatosis with quantitative ultrasound in individuals without hepatic steatosis

Kumada T, Toyoda H, Ogawa S, Gotoh T, Suzuki Y, Imajo K, Sugimoto K, Kakegawa T, Kuroda H, Yasui Y, Tamaki N, Kurosaki M, Izumi N, Akita T, Tanaka J, Nakajima A

Purpose: The effect of hepatic fibrosis stage on quantitative ultrasound based on the attenuation coefficient (AC) for liver lipid quantification is controversial. The objective of this study was to determine...
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Early Effect of Single-dose Sitagliptin Administration on Gastric Emptying: Crossover Study Using the 13C Breath Test

Nonaka T, Sekino Y, Iida H, Yamada E, Ohkubo H, Sakai E, Higurashi , Hosono K, Endo H, Koide T, Takahashi , Fujita K, Yoneda M, Goto A, Kusakabe A, Kobayashi , Gotoh E, Maeda S, Nakajima A, Nosaka C, Inamori M

  • KMID: 2325795
  • J Neurogastroenterol Motil.
  • 2013 Apr;19(2):227-232.
BACKGROUND/AIMS: The gastrointestinal motility effects of endogenous incretin hormones enhanced by dipeptidyl peptidase-IV (DPP-IV) inhibitors have not yet been sufficiently investigated. The aim of this study was to determine whether...
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Natural History of Chronic Intestinal Pseudo-obstruction and Need for Palliative Care

Tanaka K, Ohkubo H, Yamamoto A, Takahashi K, Kasai Y, Ozaki A, Iwaki M, Kobayashi T, Yoshihara T, Misawa N, Fuyuki A, Kato S, Higurashi T, Hosono K, Yoneda M, Kurihashi T, Taguri M, Nakajima A, Gwee KA, Kessoku T

  • KMID: 2544720
  • J Neurogastroenterol Motil.
  • 2023 Jul;29(3):378-387.
  • doi: 10.5056/jnm22152
Background/Aims Natural history of chronic intestinal pseudo-obstruction (CIPO), a rare disease characterized by episodes of non-mechanical obstruction, is unclear in adults. This study evaluates the clinical course of CIPO and palliative...
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Effects of Histamine-2 Receptor Antagonists and Proton Pump Inhibitors on the Rate of Gastric Emptying: A Crossover Study Using a Continuous Real-Time 13C Breath Test (BreathID System)

Nonaka T, Kessoku T, Ogawa Y, Imajyo K, Yanagisawa S, Shiba T, Sakaguchi , Atsukawa K, Takahashi , Sekino Y, Sakai E, Uchiyama T, Iida H, Hosono K, Endo H, Sakamoto Y, Fujita K, Yoneda M, Koide T, Takahashi , Tokoro C, Abe Y, Gotoh E, Maeda S, Nakajima A, Inamori M

  • KMID: 2325819
  • J Neurogastroenterol Motil.
  • 2011 Jul;17(3):287-293.
BACKGROUND/AIMS: The effects of Histamine-2 receptor antagonists and proton pump inhibitors on the gastrointestinal motility have not yet been sufficiently investigated. The aim of this study was to determine the...
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Prognosis of biopsy-confirmed metabolic dysfunction- associated steatotic liver disease: A sub-analysis of the CLIONE study

Iwaki M, Fujii H, Hayashi H, Toyoda H, Oeda S, Hyogo H, Kawanaka M, Morishita A, Munekage K, Kawata K, Tsutsumi T, Sawada K, Maeshiro T, Tobita H, Yoshida Y, Naito M, Araki A, Arakaki S, Kawaguchi T, Noritake H, Ono M, Masaki T, Yasuda S, Tomita E, Yoneda M, Tokushige A, Kamada Y, Takahashi H, Ueda S, Aishima S, Sumida Y, Nakajima A, Okanoue T, Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD)

Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) was recently proposed as an alternative disease concept to nonalcoholic fatty liver disease (NAFLD). We aimed to investigate the prognosis of patients with...
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