Clin Psychopharmacol Neurosci.
2014 Aug;12(2):75-82.
Anti-dementia Activity of Nobiletin, a Citrus Flavonoid: A Review of Animal Studies
- Affiliations
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- 1Department of Neuropsychopharmacology and Hospital Pharmacy, Graduate School of Medicine, Nagoya University, Nagoya, Japan. kyamada@med.nagoya-u.ac.jp
- 2Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan. ohizumi@tfu-mail.tfu.ac.jp
- 3Department of Anti-Dementia Functional Food Development, Research Center of Supercritical Fluid Technology, Graduate School of Engineering, Tohoku University, Sendai, Japan.
- 4Laboratory of Kampo Medicines, Yokohama College of Pharmacy, Yokohama, Japan.
- 5Kansei Fukushi Research Institute, Tohoku Fukushi University, Sendai, Japan.
Abstract
- Alzheimer's disease (AD), the most common form of dementia among the elderly, is characterized by the progressive decline of cognitive function and has a detrimental impact worldwide. Despite intensive laboratory and clinical research over the last three decades, pharmacological options for the prevention and effective long-term treatment of AD are not currently available. Consequently, successful therapeutic and preventive treatments for AD are needed. When researching materials from natural resources having anti-dementia drug activity, we identified nobiletin, a polymethoxylated flavone from the peel of Citrus depressa. Nobiletin exhibited memory-improving effects in various animal models of dementia and exerted a wide range of beneficial effects against pathological features of AD including amyloid-beta (Abeta) pathology, tau hyperphosphorylation, oxidative stress, cholinergic neurodegeneration and dysfunction of synaptic plasticity-related signaling, suggesting this natural compound could become a novel drug for the treatment and prevention of AD.
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