Int J Oral Biol.
2020 Jun;45(2):33-41. 10.11620/IJOB.2020.45.2.33.
Flavonoids as anti-inflammatory and neuroprotective agents
- Affiliations
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- 1Department of Anatomy, College of Dentistry, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea
- 2Natural Product Research Center, Korea Institute of Science and Technology, Gangneung 25451, Republic of Korea
- 3Department of Biological Chemistry, University of Science and Technology, Daejeon 34113, Republic of Korea
- 4Department of Pharmacology, College of Dentistry and Research Institute of Oral Science, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea
- KMID: 2504253
- DOI: http://doi.org/10.11620/IJOB.2020.45.2.33
Abstract
- Neuroinflammation is known as the main mechanism implicated in the advancement of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. The main feature of neuroinflammation is associated with the activation of microglia. The activated microglia increase proinflammatory cytokine production and induce progressive neuronal cell death. Citrus flavonoids show neuroprotective effects that are associated with the anti-inflammatory action of flavonoids in neurodegenerative diseases. Among these citrus flavonoids, kaempferol, naringin, and nobiletin show inhibitory effects on nuclear factor-κB and mitogen-activated protein kinase signaling pathways that can modulate inflammatory conditions in microglial cells. In the present review, we present the anti-inflammatory activities of citrus flavonoids and therapeutic potential of flavonoids as neuroprotective agents.
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