- Chlorogenic acid modulates the ubiquitin– proteasome system in stroke animal model
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Shah M, Kang J, Koh P
- KMID: 2537638
- Lab Anim Res.
- 2022 Dec;38(4):345-355.
- doi: 10.1186/s42826-022-00151-2
Background: Chlorogenic acid, a phenolic compound, has potent antioxidant and neuroprotective properties. The ubiquitin–proteasome system is an important regulators of neurodevelopment and modulators of neuronal function. This system is associated... -
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- Chlorogenic acid alleviates the reduction of Akt and Bad phosphorylation and of phospho-Bad and 14-3-3 binding in an animal model of stroke
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Shah MA, Kang JB, Kim MO, Koh PO
- KMID: 2536696
- J Vet Sci.
- 2022 Nov;23(6):e84.
- doi: 10.4142/jvs.22200
Background: Stroke is caused by disruption of blood supply and results in permanent disabilities as well as death. Chlorogenic acid is a phenolic compound found in various fruits and coffee... -
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- Protective effect of an ethanol extract mixture of Aralia elata, Chaenomeles sinensis fruit, and Glycyrrhizae radix against cerebral ischemiareperfusion injury in rats and excitotoxic and oxidative neuronal damage
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Seong YH
- KMID: 2534085
- J Biomed Transl Res.
- 2022 Jun;23(2):43-53.
- doi: 10.12729/jbtr.2022.23.2.43
Aralia elata, Chaenomeles sinensis fruit, and Glycyrrhizae radix have been widely used as oriental medicinal plants in Korea, China and Japan and found to possess anti-oxidative and anti-inflammatory activities. The... -
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- Retinoic acid regulates the ubiquitin– proteasome system in a middle cerebral artery occlusion animal model
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Kang JB, Shah MA, Park DJ, Koh PO
- KMID: 2530959
- Lab Anim Res.
- 2022 Jun;38(2):99-109.
- doi: 10.1186/s42826-022-00123-6
Background: Retinoic acid is a major metabolite of vitamin A and exerts beneficial effects including anti-oxidant and anti-inflammatory activities in neurons. The ubiquitin–proteasome system is an important biological system that... -
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- Application time and persistence of transcranial direct current stimulation (tDCS) against neuronal death resulting from transient cerebral ischemia
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Lee JH, Jung BH, Yoo KY
- KMID: 2530958
- Lab Anim Res.
- 2022 Jun;38(2):91-98.
- doi: 10.1186/s42826-022-00121-8
Background: Transcranial direct current stimulation (tDCS) has been studied as a tool to stimulate the functional recovery of neurons after stroke. Although this device has recently begun to be utilized... -
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- BMP‑6 Attenuates Oxygen and Glucose Deprivation-Induced Apoptosis in Human Neural Stem Cells through Inhibiting p38 MAPK Signaling Pathway
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Wang L, Chen Y, Wei L, He J
- KMID: 2529786
- Int J Stem Cells.
- 2022 May;15(2):144-154.
- doi: 10.15283/ijsc21093
Background and Objectives: Neural stem cells (NSCs) remain in the mammalian brain throughout life and provide a novel therapeutic strategy for central nervous system (CNS) injury. Bone morphogenetic protein-6 (BMP-6)... -
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- Impact of Testosterone on Alzheimer’s Disease
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Bianchi VE
- KMID: 2527322
- World J Mens Health.
- 2022 Apr;40(2):243-256.
- doi: 10.5534/wjmh.210175
Alzheimer’s disease (AD) is a neurodegenerative disease responsible for almost half of all dementia cases in the world and progressively increasing. The etiopathology includes heritability, genetic factors, aging, nutrition, but... -
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- Quercetin ameliorates glutamate toxicity-induced neuronal cell death by controlling calcium-binding protein parvalbumin
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Kang JB, Kang JB, Park DJ, Shah MA, Koh PO
- KMID: 2527878
- J Vet Sci.
- 2022 Mar;23(2):e26.
- doi: 10.4142/jvs.21273
Background: Glutamate is the main excitatory neurotransmitter. Excessive glutamate causes excitatory toxicity and increases intracellular calcium, leading to neuronal death. Parvalbumin is a calcium-binding protein that regulates calcium homeostasis. Quercetin... -
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- Therapeutic effects of stiripentol against ischemia-reperfusion injury in gerbils focusing on cognitive deficit, neuronal death, astrocyte damage and blood brain barrier leakage in the hippocampus
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Shin MC, Lee TK, Lee JC, Kim HI, Park CW, Cho JH, Kim DW, Ahn JH, Won MH, Lee CH
- KMID: 2524530
- Korean J Physiol Pharmacol.
- 2022 Jan;26(1):47-57.
- doi: 10.4196/kjpp.2022.26.1.47
Stiripentol is an anti-epileptic drug for the treating of refractory status epilepticus. It has been reported that stiripentol can attenuate seizure severity and reduce seizure-induced neuronal damage in animal models... -
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- Neuroprotective Effect of Astersaponin I against Parkinson’s Disease through Autophagy Induction
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Zhang L, Park JY, Zhao D, Kwon HC, Yang HO
- KMID: 2522249
- Biomol Ther.
- 2021 Nov;29(6):615-629.
- doi: 10.4062/biomolther.2021.004
An active compound, triterpene saponin, astersaponin I (AKNS-2) was isolated from Aster koraiensis Nakai (AKNS) and the autophagy activation and neuroprotective effect was investigated on in vitro and in vivo... -
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- Mechanisms of Preconditioning Exercise-Induced Neurovascular Protection in Stroke
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Hafez S, Eid Z, Alabasi S, Darwiche Y, Channaoui S, Hess DC
- KMID: 2520910
- J Stroke.
- 2021 Sep;23(3):312-326.
- doi: 10.5853/jos.2020.03006
Ischemic stroke is a leading cause of death and disability. Tissue plasminogen activator is the only U.S. Food and Drug Administration approved thrombolytic therapy for ischemic stroke patients till date.... -
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- Matrix Metalloproteinase-8 Inhibitor Ameliorates Inflammatory Responses and Behavioral Deficits in LRRK2 G2019S Parkinson’s Disease Model Mice
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Kim T, Jeon J, Park JS, Park Y, Kim J, Noh H, Kim HS, Seo H
- KMID: 2519613
- Biomol Ther.
- 2021 Sep;29(5):483-491.
- doi: 10.4062/biomolther.2020.181
Parkinson’s disease (PD) is a neurodegenerative disorder that involves the loss of dopaminergic neurons in the substantia nigra (SN). Matrix metalloproteinases-8 (MMP-8), neutrophil collagenase, is a functional player in the... -
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- The Pharmacological Properties of Silymarin and Its Constituents
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Antika LD, Dewi RM
- KMID: 2517549
- Nat Prod Sci.
- 2021 Jun;27(2):68-77.
- doi: 10.20307/nps.2021.27.2.68
Silymarin is a standardized extract obtained from the seeds and fruits of Silybum marianum L., or commonly called milk thistle, a member of Carduus marianum family that contains mix of... -
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- Role of agmatine in the application of neural progenitor cell in central nervous system diseases: therapeutic potentials and effects
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Kosonen R, Barua S, Kim JY, Lee JE
- KMID: 2516898
- Anat Cell Biol.
- 2021 Jun;54(2):143-151.
- doi: 10.5115/acb.21.089
Agmatine, the primary decarboxylation product of L-arginine, generated from arginine decarboxylase. Since the discovery of agmatine in the mammalian brain in the 1990s, an increasing number of agmatine-mediated effects have... -
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- The Relationship between Plasma Erythropoietin Levels and Symptoms of Attention Deficit Hyperactivity Disorder
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Shim Sh, Kim YK, Hwangbo Y, Yoon Hj, Kim JS, Lee YJ, Woo YS, Bahk WM
- KMID: 2516185
- Clin Psychopharmacol Neurosci.
- 2021 May;19(2):334-340.
- doi: 10.9758/cpn.2021.19.2.334
Objective: There are animal models associating dopamine dysfunction with behavioral impairments that model attention deficit hyperactivity disorder (ADHD). Erythropoietin (EPO) has trophic effects on dopaminergic neurons. The aim of this... -
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- Methyl Jasmonate: Behavioral and Molecular Implications in Neurological Disorders
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Aluko OM, Iroegbu JD, Ijomone OM, Umukoro S
- KMID: 2516174
- Clin Psychopharmacol Neurosci.
- 2021 May;19(2):220-232.
- doi: 10.9758/cpn.2021.19.2.220
Methyl jasmonate (MJ) is a derivative of the jasmonate family which is found in most tropical regions of the world and present in many fruits and vegetables such as grapevines,... -
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- Quercetin attenuates the reduction of parvalbumin in middle cerebral artery occlusion animal model
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Park DJ, Kang JB, Shah FA, Koh PO
- KMID: 2514399
- Lab Anim Res.
- 2021 Mar;37(1):74-81.
- doi: 10.1186/s42826-021-00086-0
Background: Calcium is a critical factor involved in modulation of essential cellular functions. Parvalbumin is a calcium buffering protein that regulates intracellular calcium concentrations. It prevents rises in calcium concentrations... -
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- Effects of Taro Extract on Brain Resilience in In Vitro Parkinson’s Disease Model Induced by 6-Hydroxydopamine
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Cho H, Kang K
- KMID: 2509055
- J Korean Biol Nurs Sci.
- 2020 Nov;22(4):223-231.
- doi: 10.7586/jkbns.2020.22.4.223
Purpose: The purpose of this study was to investigate the effects of taro extract on brain resilience in in vitro Parkinson’s disease model induced by 6-hydroxydopamine (6-OHDA). Methods: To induce... -
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- Genetic Inhibition of sFRP3 Prevents Glial Reactivity in a Mouse Model of Accelerated Aging
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Corujo-Ramirez AM, Dua M, Yoo KH, Oliveros A, Jang MH
- KMID: 2510831
- Int Neurourol J.
- 2020 Nov;24(Suppl 2):72-78.
- doi: 10.5213/inj.2040436.218
Purpose: Aging is the most significant risk factor for neurodegenerative disorders that are typified by cognitive deficits. Our recent work utilizing BubR1 hypomorphic (BubR1H/H) mice, an accelerated aging model, has... -
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- Inhibition of LPA5 Activity Provides Long-Term Neuroprotection in Mice with Brain Ischemic Stroke
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Sapkota A, Park SJ, Choi JW
- KMID: 2508205
- Biomol Ther.
- 2020 Nov;28(6):512-518.
- doi: 10.4062/biomolther.2020.159
Stroke is a leading cause of long-term disability in ischemic survivors who are suffering from motor, cognitive, and memory impairment. Previously, we have reported suppressing LPA5 activity with its specific... -
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