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Matrix Metalloproteinase-8 Inhibitor Ameliorates Inflammatory Responses and Behavioral Deficits in LRRK2 G2019S Parkinson’s Disease Model Mice

Kim T, Jeon J, Park JS, Park Y, Kim J, Noh H, Kim HS, Seo H

Parkinson’s disease (PD) is a neurodegenerative disorder that involves the loss of dopaminergic neurons in the substantia nigra (SN). Matrix metalloproteinases-8 (MMP-8), neutrophil collagenase, is a functional player in the...
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The Pharmacological Properties of Silymarin and Its Constituents

Antika LD, Dewi RM

Silymarin is a standardized extract obtained from the seeds and fruits of Silybum marianum L., or commonly called milk thistle, a member of Carduus marianum family that contains mix of...
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Role of agmatine in the application of neural progenitor cell in central nervous system diseases: therapeutic potentials and effects

Kosonen R, Barua S, Kim JY, Lee JE

Agmatine, the primary decarboxylation product of L-arginine, generated from arginine decarboxylase. Since the discovery of agmatine in the mammalian brain in the 1990s, an increasing number of agmatine-mediated effects have...
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The Relationship between Plasma Erythropoietin Levels and Symptoms of Attention Deficit Hyperactivity Disorder

Shim Sh, Kim YK, Hwangbo Y, Yoon Hj, Kim JS, Lee YJ, Woo YS, Bahk WM

Objective: There are animal models associating dopamine dysfunction with behavioral impairments that model attention deficit hyperactivity disorder (ADHD). Erythropoietin (EPO) has trophic effects on dopaminergic neurons. The aim of this...
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Methyl Jasmonate: Behavioral and Molecular Implications in Neurological Disorders

Aluko OM, Iroegbu JD, Ijomone OM, Umukoro S

Methyl jasmonate (MJ) is a derivative of the jasmonate family which is found in most tropical regions of the world and present in many fruits and vegetables such as grapevines,...
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Quercetin attenuates the reduction of parvalbumin in middle cerebral artery occlusion animal model

Park DJ, Kang JB, Shah FA, Koh PO

Background: Calcium is a critical factor involved in modulation of essential cellular functions. Parvalbumin is a calcium buffering protein that regulates intracellular calcium concentrations. It prevents rises in calcium concentrations...
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Protective Effect of Rice Bran Oil against β-Amyloid Protein-Induced Memory Impairment and Neuronal Death in Mice

Jang JY, Lee HK, Yoo HS, Seong YH

This study was undertaken to investigate the protective effect of rice bran oil (RBO) on amyloid β protein (Aβ) (25-35)-induced memory impairment and brain damage in an ICR mouse model....
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Neuroprotective Effect of Chronic Intracranial Toxoplasma gondii Infection in a Mouse Cerebral Ischemia Model

Lee SH, Jung BK, Song H, Seo HG, Chai JY, Oh BM

Toxoplasma gondii is an obligate intracellular protozoan parasite that can invade various organs in the host body, including the central nervous system. Chronic intracranial T. gondii is known to be...
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Flavonoids as anti-inflammatory and neuroprotective agents

Lee H, Selvaraj B, Yoo KY, Ko SH

Neuroinflammation is known as the main mechanism implicated in the advancement of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. The main feature of neuroinflammation is associated with the...
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Spinosin Inhibits Aβ1-42 Production and Aggregation via Activating Nrf2/HO-1 Pathway

Zhang X, Wang J, Gong G, Ma R, Xu F, Yan T, Wu B, Jia Y

The present research work primarily investigated whether spinosin has the potential of improving the pathogenesis of Alzheimer’s disease (AD) driven by β-amyloid (Aβ) overproduction through impacting the procession of amyloid...
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Induction of GDNF and GFRα-1 Following AAV1-Rheb(S16H) Administration in the Hippocampus in vivo

Yun D, Jeon MT, Kim HJ, Moon GJ, Lee S, Ha CM, Shin M, Kim SR

  • KMID: 2500527
  • Exp Neurobiol.
  • 2020 Apr;29(2):164-175.
  • doi: 10.5607/en19075
The activation of neurotrophic signaling pathways following the upregulation of glial cell line-derived neurotrophic factor (GDNF), a member of the transforming growth factor-β family, has a potential neuroprotective effect in...
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Effects of Taro Extract on Brain Resilience in In Vitro Parkinson’s Disease Model Induced by 6-Hydroxydopamine

Cho H, Kang K

Purpose: The purpose of this study was to investigate the effects of taro extract on brain resilience in in vitro Parkinson’s disease model induced by 6-hydroxydopamine (6-OHDA). Methods: To induce...
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Genetic Inhibition of sFRP3 Prevents Glial Reactivity in a Mouse Model of Accelerated Aging

Corujo-Ramirez AM, Dua M, Yoo KH, Oliveros A, Jang MH

Purpose: Aging is the most significant risk factor for neurodegenerative disorders that are typified by cognitive deficits. Our recent work utilizing BubR1 hypomorphic (BubR1H/H) mice, an accelerated aging model, has...
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Inhibition of LPA5 Activity Provides Long-Term Neuroprotection in Mice with Brain Ischemic Stroke

Sapkota A, Park SJ, Choi JW

Stroke is a leading cause of long-term disability in ischemic survivors who are suffering from motor, cognitive, and memory impairment. Previously, we have reported suppressing LPA5 activity with its specific...
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Antinociceptive and neuroprotective effects of bromelain in chronic constriction injury-induced neuropathic pain in Wistar rats

Bakare AO, Owoyele BV

Background: The continuous search for a novel neuropathic pain drug with few or no side effects has been a main focus of researchers for decades. This study investigated the antinociceptive...
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Neuroprotective potential of imatinib in global ischemia-reperfusion-induced cerebral injury: possible role of Janus-activated kinase 2/signal transducer and activator of transcription 3 and connexin 43

Wang J, Bai T, Wang N, Li H, Guo X

The present study was aimed to explore the neuroprotective role of imatinib in global ischemia-reperfusion-induced cerebral injury along with possible mechanisms. Global ischemia was induced in mice by bilateral carotid...
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HDAC Inhibition by Valproic Acid Induces Neuroprotection and Improvement of PD-like Behaviors in LRRK2 R1441G Transgenic Mice

Kim T, Song S, Park Y, Kang S, Seo H

Parkinson’s disease (PD) is one of the late-onset neurodegenerative movement disorder. Major pathological markers of PD include progressive loss of dopaminergic neurons, Lewy body formation, genetic mutations, and environmental factors....
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tPA Helpers in the Treatment of Acute Ischemic Stroke: Are They Ready for Clinical Use?

Kim JS

Tissue plasminogen activator (tPA) is the only therapeutic agent approved to treat patients with acute ischemic stroke. The clinical benefits of tPA manifest when the agent is administered within 4.5...
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Characterization of Vitamin B12 Supplementation and Correlation with Clinical Outcomes in a Large Longitudinal Study of Early Parkinson's Disease

Dietiker C, Kim S, Zhang Y, Christine , on behalf of the NINDS NET-PD Investigators

OBJECTIVE: In Parkinson's disease (PD), vitamin B12 levels are lower, and comorbid B12 deficiency has been associated with the development of neuropathy and early gait instability. Because little is known...
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Gadd45b Acts as Neuroprotective Effector in Global Ischemia-Induced Neuronal Death

Cho CH, Byun HR, Jover-Mengual T, Pontarelli F, Dejesus C, Cho AR, Zukin RS, Hwang JY

PURPOSE: Transient global ischemia arising in human due to cardiac arrest causes selective, delayed neuronal death in hippocampal CA1 and cognitive impairment. Growth arrest and DNA-damage-inducible protein 45 beta (Gadd45b)...
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