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A single nonsteroidal anti-inflammatory drugs-induced anaphylaxis to diclofenac confirmed by skin testing

Lee J

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a major culprit of drug-induced hypersensitivity. No reliable diagnostic tests other than a direct challenge are available. Cross-reactivity among NSAIDs that inhibit cyclooxygenase-1 is common....
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A Nationwide Cohort Study Shows a Sex-Dependent Change in the Trend of Peptic Ulcer Bleeding Incidence in Korea between 2006 and 2015

Kim YS, Lee J, Shin A, Lee JM, Park JH, Jung HY

Background/Aims: The incidence of peptic ulcer disease has decreased in past decades; however, the trends in peptic ulcer bleeding (PUB) are inconsistent among regions. This study aimed to investigate the...
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An Unusual Case of Colon Perforation With Multiple Transmural Ulcers After Use of Polmacoxib and Everolimus in a Metastatic Breast Cancer Patient

Song IG, Jung KU, Kim HO, Kim H, Chun HK

Everolimus (Afinitor) is an inhibitor of mammalian target of rapamycin. Polmacoxib (Acelex) is a nonsteroidal anti-inflammatory drug that belongs to the cyclooxygenase-2 (COX-2) inhibitor family and is mainly used for...
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An Overview of Cancer Prevention: Chemoprevention and Immunoprevention

Gu KJ, Li G

ancer prevention encompasses a broad spectrum of strategies designed to lower the chance of developing cancer and reduce the morbidity of established cancer. There are three levels of cancer prevention....
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Prevalence of Gastrointestinal and Cardiovascular Risk in Patients with Degenerative Lumbar Spinal Disease

Yang JH, Lee BH, Eum KS, Suk KS, Park JO, Kim HS, Lee HM, Moon SH

Background: Limited information is available about the proportion of patients with degenerative lumbar spinal disease (DLSD) who have gastrointestinal (GI) and cardiovascular (CV) risk factors. Many DLSD patients are prescribed...
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Clinical Guidelines for Drug-induced Peptic Ulcer, 2020 Revised Edition

Joo MK, Park CH, Kim JS, Park JM, Ahn JY, Lee BE, Lee JH, Yang HJ, Cho YK, Bang CS, Kim BJ, Jung HK, Kim BW, Lee YC, Korean College of Helicobacter and Upper Gastrointestinal Research

The Korean guidelines for nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcers were previously developed under co-work with the Korean College of Helicobacter and Upper Gastrointestinal Research and Korean Society of Gastroenterology...
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Flavonoids as anti-inflammatory and neuroprotective agents

Lee H, Selvaraj B, Yoo KY, Ko SH

Neuroinflammation is known as the main mechanism implicated in the advancement of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. The main feature of neuroinflammation is associated with the...
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Prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis with rectal non-steroidal anti-inflammatory drugs

Park TY, Oh HC, Fogel EL, Lehman GA

Acute pancreatitis is the most common and feared adverse event associated with performance of endoscopic retrograde cholangiopancreatography (ERCP). Unremitting effort has been made for over 40 years to minimize the...
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All about pain pharmacology: what pain physicians should know

Kim KH, Seo HJ, Abdi S, Huh B

From the perspective of the definition of pain, pain can be divided into emotional and sensory components, which originate from potential and actual tissue damage, respectively. The pharmacologic treatment of...
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Potential Strategies in the Prevention of Nonsteroidal Anti-inflammatory Drugs-Associated Adverse Effects in the Lower Gastrointestinal Tract

Guo CG, Leung WK

With the increasing use of nonsteroidal anti-inflammatory drugs (NSAIDs), the incidence of lower gastrointestinal (GI) complications is expected to increase. However, unlike upper GI complications, the burden, pathogenesis, prevention and...
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A comprehensive review and the pharmacologic management of primary dysmenorrhea

Lee D, Kim SK

Dysmenorrhea is the most common gynecologic condition in women during the reproductive period. Severe dysmenorrhea pain affects their social activities, sleep, and quality of life. Nevertheless, the proportion of women...
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Anti-inflammatory Strategies for Schizophrenia: A Review of Evidence for Therapeutic Applications and Drug Repurposing

Hong J, Bang M

Schizophrenia is a debilitating psychiatric disorder with a substantial socioeconomic and humanistic burden. Currently available treatment strategies mostly rely on antipsychotic drugs, which block dopaminergic effects in the mesolimbic pathway...
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Current Guidelines for Non-Steroidal Anti-Inflammatory Drugs

Park MG, Yoo JD, Lee KH

Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs worldwide for chronic pain, such as arthritis, and there are many different types depending on their composition and mechanism. After...
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Effect of 0.1% Bromfenac for Preventing Macular Edema after Cataract Surgery in Patients with Diabetes

Song SH, Baek SK, Lee MW, Lee YH

PURPOSE: To investigate the effect of 0.1% bromfenac sodium hydrate ophthalmic solution for prevention of macular edema after cataract surgery in patients with diabetes. METHODS: A retrospective analysis of 75 patients...
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Aspirin and Non-steroidal Anti-inflammatory Drugs in Prevention of Gastric Cancer

Kim YJ, Chung WC

  • KMID: 2509972
  • J Dig Cancer Rep.
  • 2020 Dec;8(2):77-80.
Gastric cancer is one of the leading causes of cancer-related deaths worldwide. The increased expression of cyclooxygenase (COX)-2 has been implicated in the development and progression of gastric cancers. A...
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Effect of Topical Bromfenac as a Treatment of Cystoid Macular Edema Following Pars Plana Vitrectomy

Moon CW, Park DG, Sagong M

Purpose: To investigate the functional and anatomical effectiveness of bromfenac sodium hydrate ophthalmic solution for the treatment of cystoid macular edema (CME) after pars plana vitrectomy (PPV). Methods: A retrospective chart...
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Prevention of Non-steroidal Anti-inflammatory Drug-induced Peptic Ulcers

Chu SJ, Yoon KT, Kim JS

Nonsteroidal anti-inflammatory drugs (NSAID) are some of the most commonly prescribed medications in clinical practice. The long-term use of NSAIDs is one of the main causes of peptic ulcers and...
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Helicobacter pylori Eradication in Drug-related Peptic Ulcer

Joo MK

Non-steroidal anti-inflammatory drugs (NSAIDs) and aspirin are the most frequently prescribed drugs worldwide, and their long-term use often leads to peptic ulcers (PUs) along with serious complications, such as bleeding...
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Clinical Guidelines for Drug-Related Peptic Ulcer, 2020 Revised Edition

Joo MK, Park CH, Kim JS, Park JM, Ahn JY, Lee BE, Lee JH, Yang HJ, Cho YK, Bang CS, Kim BJ, Jung HK, Kim BW, Lee YC, Korean College of Helicobacter and Upper Gastrointestinal Research

Korean guidelines for nonsteroidal anti-inflammatory drug (NSAID)-induced peptic ulcer were previously developed in 2009 with the collaboration of the Korean College of Helico-bacter and Upper Gastrointestinal Research and Korean So-ciety...
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Topical agents: a thoughtful choice for multimodal analgesia

Choi E, Nahm FS, Han WK, Lee PB, Jo J

For over a thousand years, various substances have been applied to the skin to treat pain. Some of these substances have active ingredients that we still use today. However,...
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