Biomol Ther.  2019 May;27(3):241-253. 10.4062/biomolther.2019.034.

Flavonoids: Broad Spectrum Agents on Chronic Inflammation

• Lim H
• Heo MY
• Kim HP

• KMID: 2447851
• DOI: http://doi.org/10.4062/biomolther.2019.034

Abstract

Flavonoids are major plant constituents with numerous biological/pharmacological actions both in vitro and in vivo. Of these actions, their anti-inflammatory action is prominent. They can regulate transcription of many proinflammatory genes such as cyclooxygenase-2/inducible nitric oxide synthase and many cytokines/chemokines. Recent studies have demonstrated that certain flavonoid derivatives can affect pathways of inflammasome activation and autophagy. Certain flavonoids can also accelerate the resolution phase of inflammation, leading to avoiding chronic inflammatory stimuli. All these pharmacological actions with newly emerging activities render flavonoids to be potential therapeutics for chronic inflammatory disorders including arthritic inflammation, meta-inflammation, and inflammaging. Recent findings of flavonoids are summarized and future perspectives are presented in this review.

Keyword

Flavonoid; Chronic inflammation; Therapeutics; Inflammaging; Meta-inflammation

MeSH Terms

Autophagy
Flavonoids*
In Vitro Techniques
Inflammasomes
Inflammation*
Nitric Oxide Synthase
Plants
Flavonoids
Inflammasomes
Nitric Oxide Synthase