Biomol Ther.  2017 Mar;25(2):91-104. 10.4062/biomolther.2016.187.

Therapeutic Potential of Medicinal Plants and Their Constituents on Lung Inflammatory Disorders

• Kim HP
• Lim H
• Kwon YS

• KMID: 2375028
• DOI: http://doi.org/10.4062/biomolther.2016.187

Abstract

Acute bronchitis and chronic obstructive pulmonary diseases (COPD) are essentially lung inflammatory disorders. Various plant extracts and their constituents showed therapeutic effects on several animal models of lung inflammation. These include coumarins, flavonoids, phenolics, iridoids, monoterpenes, diterpenes and triterpenoids. Some of them exerted inhibitory action mainly by inhibiting the mitogen-activated protein kinase pathway and nuclear transcription factor-κB activation. Especially, many flavonoid derivatives distinctly showed effectiveness on lung inflammation. In this review, the experimental data for plant extracts and their constituents showing therapeutic effectiveness on animal models of lung inflammation are summarized.

Keyword

Medicinal plant; Lung inflammation; COPD; Constituent; Flavonoid

MeSH Terms

Bronchitis
Coumarins
Diterpenes
Flavonoids
Iridoids
Lung Diseases, Obstructive
Lung*
Models, Animal
Monoterpenes
Phenol
Plant Extracts
Plants, Medicinal*
Pneumonia
Protein Kinases
Pulmonary Disease, Chronic Obstructive
Therapeutic Uses
Coumarins
Diterpenes
Flavonoids
Iridoids
Monoterpenes
Phenol
Plant Extracts
Protein Kinases
Therapeutic Uses