Biomol Ther.  2016 Jan;24(1):67-74. 10.4062/biomolther.2015.070.

Inhibition of Lung Inflammation by Acanthopanax divaricatus var. Albeofructus and Its Constituents

• Lee JH
• Sun YN
• Kim YH
• Lee SK
• Kim HP

• KMID: 2170543
• DOI: http://doi.org/10.4062/biomolther.2015.070

Abstract

In order to find potential therapeutic agents on lung inflammatory conditions, the extracts of Acanthopanax divaricatus var. albeofructus were prepared and its constituents were isolated. They include lignans such as (+)-syringaresinol (1), acanthoside B (2), salvadoraside (3) and acanthoside D (4), lariciresinol-9-O-beta-D-glucopyranoside (5) and phenylpropanoids such as 4-[(1E)-3-methoxy-1-propenyl]phenol (6), coniferin (7), and methyl caffeate (8). The extracts and several constituents such as compound 1, 6 and 8 inhibited the production of inflammatory markers, IL-6 and nitric oxide, from IL-1beta-treated lung epithelial cells and lipopolysaccharide (LPS)-treated alveolar macrophages. Furthermore, the extracts and compound 4 significantly inhibited lung inflammation in lipolysaccharide-treated acute lung injury in mice by oral administration. Thus it is suggested that A. divaricatus var. albeofructus and its several constituents may be effective against lung inflammation.

Keyword

Acantopanax divaricatus var. albeofructus; Lung inflammation; Acanthoside; Macrophage

MeSH Terms

Eleutherococcus*
Acute Lung Injury
Administration, Oral
Animals
Epithelial Cells
Interleukin-6
Lignans
Lung*
Macrophages
Macrophages, Alveolar
Mice
Nitric Oxide
Pneumonia*
Interleukin-6
Lignans
Nitric Oxide