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The Usefulness of Symptom-based Subtypes of Functional Dyspepsia for Predicting Underlying Pathophysiologic Mechanisms and Choosing Appropriate Therapeutic Agents

Lee KJ

  • KMID: 2517526
  • J Neurogastroenterol Motil.
  • 2021 Jul;27(3):326-336.
  • doi: 10.5056/jnm21042
Functional dyspepsia (FD) is considered to be a heterogeneous disorder with different pathophysiological mechanisms or pathogenetic factors. In addition to traditional mechanisms, novel concepts regarding pathophysiologic mechanisms of FD have...
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Suboptimal Management Status of Younger Hypertensive Population in Korea

Lee HY, Oh GC, Sohn IS, Park S, Shin J, Pyun WB, Cho MC

Background and Objectives: Hypertension (HTN) is the most contributable risk factor for cardiovascular disease. May Measurement Month (MMM) is a global initiative to raise awareness of HTN and act as...
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Risk Factors for Acute Cholangitis Caused by Enterococcus faecalis and Enterococcus faecium

Karasawa Y, Kato J, Kawamura S, Kojima K, Ohki T, Seki M, Tagawa K, Toda N

Background/Aims: Acute cholangitis (AC) is a potentially life-threatening bacterial infection, and timely antimicrobial treatment, faster than that achieved with bacterial cultures, is recommended. Although the current guidelines refer to empirical antimicrobial...
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Oral Administration and Intralesional Injection of Hyaluronic Acid Versus Intralesional Injection Alone in Peyronie’s Disease: Results from a Phase III Study

Cai T, Tiscione D, Favilla V, Puglisi M, Palumbo F, Zucchi A, Malossini G, Palmieri A, Johansen TEB

Purpose: The aim of this study was to compare the effect of combined oral administration and intralesional injection of hyaluronic acid (HA) with intralesional injections alone, in patients with early...
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Clinical Application of Digital Therapeutics for Insomnia

Cho CH

Insomnia is one of the most common sleep disorders experienced by modern people, and treatment is often not adequate due to various limitations. Digital therapeutics for insomnia are expected to...
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Oxytocin: A Potential Therapeutic for Obesity

Hong SM, Ko JK, Moon JJ, Kim YR

Oxytocin is a neuropeptide involved in the homeostasis of food consumption and energy; it affects hedonic eating. Studies in obese or binge-eating patients reported the hypophagic effect of oxytocin, which...
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Update on Glucocorticoid Induced Osteoporosis

Cho SK, Sung YK

Glucocorticoids are used to treat many autoimmune and inflammatory diseases. However, an adverse systemic effect is a deleterious effect on bone, which may lead to glucocorticoid-induced osteoporosis, characterized by a...
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Recent Trends in Tailored Treatments for Helicobacter pylori Infection

Park H, Lee JH

The efficacy of the standard triple eradication regimen for Helicobacter pylori (H. pylori) infection is gradually decreasing due to increased antibiotic resistance of H. pylori, which is represented by clarithromycin...
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Pediatric-onset Inflammatory Bowel Disease: What Are Different from Adult in the Treatment?

Choi S, Moon W

Pediatric-onset inflammatory bowel disease differs from adults in its epidemiological and clinical characteristics and courses. Since it is diagnosed at a young age, the duration of the disease is relatively...
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Recent Update on Treatment and Management of Rapid Eye Movement Sleep Behavior Disorder

Byun JI, Shin WC

Rapid eye movement sleep behavior disorder (RBD) is a parasomnia that is characterized by dream-enactment behavior, which can often result in sleep related injury. RBD is strongly associated with neurodegenerative...
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Roles of Type I and III Interferons in COVID-19

Choi H, Shin EC

Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I and III interferon (IFN) responses act as the first line...
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Basic Knowledge that Doctors Starting ERCP Should Know

Lee JW, Nam HS

The first endoscopic retrograde cholangiopancreatography (ERCP) wad performed in 1968. With tremendous progress in techniques, instruments and devices, ERCP has played an important role in modern medicine for the diagnosis...
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Recent Update of Accessories for ERCP

Lee TY

Endoscopic retrograde cholangiopancreatography (ERCP) became the standard method of choice for the management of patients with a variety of benign and malignant pancreaticobiliary disorders. A growing range of ERCP accessories...
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Recent advances in the understanding of the molecular pathogenesis and targeted therapy options in Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is the most common histiocytic disorder caused by the clonal expansion of myeloid precursors that differentiate into CD1a+/CD207+ cells in the lesion. Advances in genomic sequencing...
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Active Surveillance of Papillary Thyroid Cancer: Past, Present, and Future

Kim JK, Kwon H, Lim W, Moon BI, Paik NS

Active surveillance (AS) of papillary thyroid microcarcinoma was first suggested by Dr. Akira Miyauchi at Kuma Hospital in 1993. Based on several subsequent evidences, AS was approved by the American...
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Therapeutic New Era for Atopic Dermatitis: Part 2. Small Molecules

Ahn J, Choi Y, Simpson EL

Atopic dermatitis (AD) is a chronic, inflammatory cutaneous disease driven by immune dysregulation and skin barrier dysfunction. Currently, we are experiencing a new era of understanding of the pathogenesis of...
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Operationalizing Treat-to-Target for Osteoporosis

Lewiecki EM

Treat-to-target (TTT) for osteoporosis is a concept for individualizing patient treatment decisions that focuses on achieving an acceptable level of fracture risk rather than response to treatment alone. While a...
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Evaluation and management of extrahepatic manifestations of nonalcoholic fatty liver disease

Wijarnpreecha K, Aby ES, Ahmed A, Kim D

Nonalcoholic fatty liver disease (NAFLD) is a multisystemic disease and a rapidly growing cause of chronic liver disease in children and adults worldwide. Diagnosis and management of extrahepatic manifestations of...
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The impact of tobacco smoking on treatment choice and efficacy in inflammatory bowel disease

Nicolaides S, Vasudevan A, Long T, van Langenberg D

Smoking significantly increases the risk of developing and worsens Crohn’s disease (CD), yet protects against the development and reduces the severity of ulcerative colitis. It is less clear whether smoking...
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Management of keloid scars: noninvasive and invasive treatments

Kim SW

Scars vary from mature linear scars to abnormal excessive scars such as hypertrophic scars and keloid scars. Keloid scars are fibro-proliferative disease entities that reflect an abnormal process of wound...
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