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The mechanism of human neural stem cell secretomes improves neuropathic pain and locomotor function in spinal cord injury rat models: through antioxidant, anti-inflammatory, anti-matrix degradation, and neurotrophic activities

Semita IN, Utomo DN, Suroto H, Sudiana IK, Gandi P

Background: Globally, spinal cord injury (SCI) results in a big burden, including 90% suffering permanent disability, and 60%–69% experiencing neuropathic pain. The main causes are oxidative stress, inflammation, and degeneration....
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Melatonin Attenuates Mitochondrial Damage in Aristolochic AcidInduced Acute Kidney Injury

Sun J, Pan J, Liu Q, Cheng J, Tang Q, Ji Y, Cheng K, wang R, Liu L, Wang D, Wu N, Zheng X, Li J, Zhang X, Zhu Z, Ding Y, Zheng F, Li J, Zhang Y, Yuan Y

Aristolochic acid (AA), extracted from Aristolochiaceae plants, plays an essential role in traditional herbal medicines and is used for different diseases. However, AA has been found to be nephrotoxic and...
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Inhibition of MicroRNA-92a Improved Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats via Suppressing Oxidative Stress and Endothelial Dysfunction

Tang Z, Song J, Yu Z, Cui K, Ruan Y, Liu Y, Wang T, Wang S, Liu J, Yang J

Purpose: To determine whether microRNA could be a therapy target of erectile dysfunction (ED) and the underlying mechanisms. Materials and Methods: Eight-week-old fasting male SD rats were intraperitoneally injected with streptozotocin...
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Mitochondrial oxidative stress regulatory approaches for diabetic encephalopathy

Kim HJ, Kim DH, Jo HH, Lee HJ

Diabetic encephalopathy is a major complication with cognitive impairment and neurodegeneration in patients with type 1 or type 2 diabetes mellitus (DM). DM-induced glucolipotoxicity is a risk factor for Alzheimer’s...
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Chlorogenic acid attenuates pro‑inflammatory response in the blood of streptozotocin‑induced diabetic rats

Lee Y, Bae C, Ahn T

Background: Chlorogenic acid (CGA) has been shown to reduce pro-inflammation by scavenging reactive oxy‑ gen species (ROS) and reactive nitrogen species. In this study, the anti-inflammatory effect of CGA was...
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Time progression and regional expression of brain oxidative stress induced by obstructive jaundice in rats

Lilimpakis K, Tsepelaki A, Kalaitzopoulou E, Zisimopoulos D, Papadea P, Skipitari M,  Varemmenou A, Aggelis A,  Vagianos C,  Constantoyannis C, Georgiou C

Background: Obstructive jaundice induces oxidative changes in the brain parenchyma and plays significant role in clinical manifestations of hepatic encephalopathy. We aim to study the progression of the brain oxidative...
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Green perilla leaf extract ameliorates long-term oxidative stress induced by a high-fat diet in aging mice

Edward OC, Thomas SS, Cha KO, Jung HA, Han A, Cha YS

BACKGROUND/OBJECTIVES: Oxidative stress is caused by an imbalance between harmful free radicals and antioxidants. Long-term oxidative stress can lead to an “exhausted” status of antioxidant defense system triggering development of...
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Effects of sleep deprivation on coronary heart disease

Wei R, Duan X, Guo L

The presence of artificial light enables humans to be active 24 h a day. Many people across the globe live in a social culture that encourages staying up late to meet...
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Epigallocatechin-3-gallate suppresses hemin-aggravated colon carcinogenesis through Nrf2-inhibited mitochondrial reactive oxygen species accumulation

Seok JH, Kim DH, Kim HJ, Jo HH, Kim EY, Jeong JH, Park YS, Lee SH, Kim DJ, Nam SY, Lee BJ, Lee HJ

Background: Previous studies have presented evidence to support the significant association between red meat intake and colon cancer, suggesting that heme iron plays a key role in colon carcinogenesis. Epigallocatechin-3-gallate...
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Ventilator-induced lung injury results in oxidative stress response and mitochondrial swelling in a mouse model

Joelsson JP, Asbjarnarson A, Sigurdsson S, Kricker J, Valdimarsdottir B, Thorarinsdottir H, Starradottir E, Gudjonsson T, Ingthorsson S, Karason S

Background: Mechanical ventilation is a life-saving therapy for critically ill patients, providing rest to the respiratory muscles and facilitating gas exchange in the lungs. Ventilator-induced lung injury (VILI) is an...
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NADPH oxidase inhibitor development for diabetic nephropathy through water tank model

Lee HE, Shim S, Choi Y, Bae YS

Oxidative stress can cause generation of uncontrolled reactive oxygen species (ROS) and lead to cytotoxic damage to cells and tissues. Recently, it has been shown that transient ROS generation can...
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Intrathecal administration of naringenin improves motor dysfunction and neuropathic pain following compression spinal cord injury in rats: relevance to its antioxidant and anti-inflammatory activities

Fakhri S, Sabouri S, Kiani A, Farzaei MH, Rashidi K, Mohammadi-Farani A, Mohammadi-Noori E, Abbaszadeh F

Background: Spinal cord injury (SCI) is one of the most debilitating disorders throughout the world, causing persistent sensory-motor dysfunction, with no effective treatment. Oxidative stress and inflammatory responses play key...
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Comprehensive investigations of key mitochondrial metabolic changes in senescent human fibroblasts

Ghneim HK, Alfhili MA, Alharbi SO, Alhusayni SM, Abudawood M, Aljaser FS, Al-Sheikh YA

There is a paucity of detailed data related to the effect of senescence on the mitochondrial antioxidant capacity and redox state of senescent human cells. Activities of TCA cycle enzymes, respiratory...
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Effects of Antioxidant on Oxidative Stress and Autophagy in Bronchial Epithelial Cells Exposed to Particulate Matter and Cigarette Smoke Extract

Hur J, Rhee CK, Jo YS

Background: We evaluated the effect of particulate matter (PM) and cigarette smoke extract (CSE) on bronchial epithelial cell survival, as well as oxidative stress and autophagy levels. Moreover, we aimed...
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Role of Nuclear Factor Erythroid 2-Related Factor 2 in Chronic Obstructive Pulmonary Disease

Ban WH, Rhee CK

Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation due to chronic airway inflammation and destruction of the alveolar structure from persistent exposure to oxidative stress. The body has...
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Aging-Associated Changes in Oxidative Stress Negatively Impacts the Urinary Bladder Urothelium

de Rijk MM, Wolf-Johnston A, Kullmann AF, Taiclet S, Kanai AJ, Shiva S, Birder LA

Purpose: Lower urinary tract symptoms are known to significantly increase with age, negatively impacting quality of life and self-reliance. The urothelium fulfills crucial tasks, serving as a barrier protecting the...
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Antioxidant, anti-inflammatory, and anti-fibrotic properties of olive leaf extract protect against L-arginine induced chronic pancreatitis in the adult male albino rat

Romeh GH, El-Safty FENAH, El-Mehi AES, Faried MA

Chronic pancreatitis (CP) is an inflammatory disease affects the pancreas with upcoming fibrosis and notable parenchymal destruction. CP poses a high risk for pancreatic carcinoma. The present study aimed to...
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An overview of radiation-induced heart disease

Ellahham S, Khalouf A, Elkhazendar M, Dababo N, Manla Y

Radiation therapy (RT) has dramatically improved cancer survival, leading to several inevitable complications. Unintentional irradiation of the heart can lead to radiation-induced heart disease (RIHD), including cardiomyopathy, pericarditis, coronary artery...
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Effect of aqueous Nigella sativa extract on the functional parameters of post-thaw human spermatozoa during vitrification

Nasiri Z, Ghorbani F, Seify M, Sharbati A

Objective: Sperm vitrification leads to the production of reactive oxygen species (ROS) that can damage the functional parameters of sperm. The present study aimed to investigate the antioxidant effect of...
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Protective action of polysaccharides from Laurencia papillose (Rhodophyta) against imidacloprid induced genotoxicity and oxidative stress in male albino rats

Abdelhafez HEDH, AbdAllah AA, Afify MM, Mahmoud NF, Guo J, Murad SA, Ibrahim EA

Imidacloprid (IMI), the main component of neonicotinoid insecticides, promotes oxidative stress and genotoxicity in mammals. The aim of this experiment is to assess oxidative stress in liver cells and genotoxicity...
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