J Neurogastroenterol Motil.  2013 Apr;19(2):227-232.

Early Effect of Single-dose Sitagliptin Administration on Gastric Emptying: Crossover Study Using the 13C Breath Test

Affiliations
  • 1Gastroenterology Division, Yokohama City University Hospital, Yokohama, Japan.
  • 2Department of Medical Education, Yokohama City University School of Medicine, Yokohama, Japan.
  • 3Marketing Department, Kyowa Hakko Kirin Co., Ltd. Tokyo, Japan.
  • 4Office of Postgraduate Medical Education, Yokohama City University Hospital, Yokohama, Japan. inamorim@med.yokohama-cu.ac.jp

Abstract

BACKGROUND/AIMS
The gastrointestinal motility effects of endogenous incretin hormones enhanced by dipeptidyl peptidase-IV (DPP-IV) inhibitors have not yet been sufficiently investigated. The aim of this study was to determine whether single pre-prandial sitagliptin, the DPP-IV inhibitor, administration might have an effect on the rate of liquid gastric emptying using the 13C-acetic acid breath test.
METHODS
Ten healthy male volunteers participated in this randomized, two-way crossover study. The subjects fasted for overnight and were randomly assigned to receive 50 mg sitagliptin 2 hours before ingestion of the liquid test meal (200 kcal per 200 mL, containing 100 mg 13C-acetate) or the test meal alone. Under both conditions, breath samples were collected for 150 minutes following the meal. Liquid gastric emptying was estimated by the values of the following parameters: the time required for 50% emptying of the labeled meal (T1/2), the analog to the scintigraphy lag time for 10% emptying of the labeled meal (Tlag), the gastric emptying coefficient and the regression-estimated constants (beta and kappa), calculated by using the 13CO2 breath excretion curve using the conventional formulae. The parameters between the 2 test conditions were compared statistically.
RESULTS
No significant differences in the calculated parameters, including T1/2, Tlag, gastric emptying coefficient or beta and kappa, were observed between the 2 test conditions.
CONCLUSIONS
The present study revealed that single-dose sitagliptin intake had no significant influence on the rate of liquid gastric emptying in asymptomatic volunteers.

Keyword

Breath tests; Gastric emptying; Sitagliptin

MeSH Terms

Breath Tests
Cross-Over Studies
Eating
Gastric Emptying
Gastrointestinal Motility
Humans
Incretins
Male
Meals
Pyrazines
Triazoles
Sitagliptin Phosphate
Incretins
Pyrazines
Triazoles
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