Korean J Gastroenterol.  2001 Dec;38(6):405-410.

Correlation between DOB30 of 13C - Urea Breath Test and Proximal Gastric Motor Functions in Functional Dyspepsia

• Shim SG
• Rhee PL
• Hyun JG
• Kim JE
• Sung IK
• Jang JK
• Ryu KH
• Kim YH
• Kim JJ
• Koh KC
• Paik SW
• Rhee JC
• Choi KW
• Kim HS

Abstract

BACKGROUND/AIMS: 13C-urea breath test (UBT) is accepted as an accurate test to detect Helicobacter pylori (H. pylori) infection. The results of UBT could be correlated with the extent of H. pylori colonization density or the severity of the gastric mucosal inflammation. We examined whether UBT values correlated with some parameters for proximal gastric motor functions in functional dyspepsia (FD).
METHODS
Twelve patients with FD and H. pylori infection confirmed by UBT were included. Breath samples were taken before and 30 min after 75 mg 13C-urea ingestion and analyzed by isotope mass spectrometry. The results of UBT were expressed as the difference between value at 30 min and value at baseline (DOB30). Gastric emptying scintigraphy and gastric barostat study were performed to measure the proximal gastric motor functions.
RESULTS
No significant correlation was found between DOB30 and proximal half-emptying time (r=-0.34, p=0.28), DOB30 and proximal gastric distribution of meal at 1 min images (r=0.03, p=0.93). According to the gastric barostat study, basal tone (r=0.53, p=0.07), compliance (r=-0.05, p=0.86), and gastric accommodation (r=-0.08, p=0.79) were not associated with DOB30.
CONCLUSION
DOB30 does not correlate with proximal gastric motor parameters in patients with FD.

MeSH Terms

Breath Tests*
Colon
Compliance
Dyspepsia*
Eating
Gastric Emptying
Helicobacter pylori
Humans
Inflammation
Mass Spectrometry
Meals
Radionuclide Imaging
Urea*
Urea