Korean J Gastroenterol.  1999 Dec;34(6):717-723.

Association of Helicobacter pylori Infection with Gastric Hypersensitivity in Functional Dyspepsia

• Kim JE
• Rhee PL
• Kim YH
• Son HJ
• Kim JJ
• Koh KC
• Paik SW
• Rhee JC
• Choi KW

Abstract

BACKGROUND/AIMS: Recently, the concept of gastric hypersensitivity was introduced as an important factor in the pathophysiology of functional dyspepsia. We evaluated the relationship between Helicobacter pylori (H. pylori) infection and gastric sensitivity to distention to define the role of H. pylori in the pathogenesis of functional dyspepsia.
METHODS
Gastric barostat, and 13C urea breath test were performed in 34 consecutive patients with functional dyspepsia.
RESULTS
Between H. pylori-positive and H. pylori-negative patients with functional dyspepsia, there was no significant difference in basal tone (57.2+/-15.0 mL vs. 66.8+/-18.3 mL), compliance (41.0+/-11.2 mL/mmHg vs. 38.2+/-11.8 mL/mmHg), threshold of abdominal discomfort (9.4+/-4.0 mmHg vs. 7.3+/-1.9 mmHg) and postprandial receptive relaxation (115.4+/-89.7 mL vs. 99.0+/-88.7 mL) according to the results measured by gastric barostat.
CONCLUSIONS
H. pylori infection was not associated with gastric hypersensitivity to distention.

Keyword

Helicobacter pylori; Functional dyspepsia; Gastric hypersensitivity; Barostat

MeSH Terms

Breath Tests
Compliance
Dyspepsia*
Helicobacter pylori*
Helicobacter*
Humans
Hypersensitivity*
Relaxation
Urea
Urea