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Efficacy and Safety of AlbisD Compared With Omeprazole 20 mg in Patients With Non-erosive Reflux Disease: A Randomized, Open-label, Active-controlled, Pilot Study

Kim EJ, Lee OY, Lee KN, Lee SJ, Jang JY, Cho JW, Kim TO

  • KMID: 2454639
  • J Neurogastroenterol Motil.
  • 2019 Jul;25(3):403-412.
  • doi: 10.5056/jnm18185
BACKGROUND/AIMS: Proton pump inhibitors (PPIs) are frequently used to treat non-erosive reflux disease (NERD), but their effect is limited. It is not known whether a potential alternative, AlbisD, containing ranitidine...
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National Survey Assessing Treatment of Helicobacter pylori Infection in Korean Children: A Pilot Study

Youn JH, Kim SJ, Seo JH, Kim JY, Youn HS, Ko JS, Kim KM, Chung JY

BACKGROUND/AIMS: The standard guideline for the management Helicobacter pylori infection in Korean children is not present until now. In present study, we conducted the questionnaire survey to investigate the real...
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Effects of CYP2C19 Genetic Polymorphisms on PK/PD Responses of Omeprazole in Korean Healthy Volunteers

Park S, Hyun YJ, Kim YR, Lee JH, Ryu S, Kim JM, Oh WY, Na HS, Lee JG, Seo DW, Hwang IY, Park Z, Jang IJ, Oh J, Choi SE

The aim of this study was to examine the effects of CYP2C19*2 and *3 genetic polymorphisms on omeprazole pharmacokinetic (PK) and pharmacodynamic (PD) responses. Twenty-four healthy Korean volunteers were enrolled...
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Esophageal Acidification During Nocturnal Acid-breakthrough with Ilaprazole Versus Omeprazole in Gastroesophageal Reflux Disease

Karyampudi A, Ghoshal UC, Singh R, Verma A, Misra A, Saraswat V

  • KMID: 2433521
  • J Neurogastroenterol Motil.
  • 2017 Apr;23(2):208-217.
  • doi: 10.5056/jnm16087
BACKGROUND/AIMS: Though nocturnal acid-breakthrough (NAB) is common in gastroesophageal reflux disease (GERD) patients, its clinical importance results from esophageal acidification, which has been shown to be uncommon. Ilaprazole, a long-acting...
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Helicobacter pylori Eradication Downregulates Cellular Inhibitor of Apoptosis Protein 2 in Gastric Carcinogenesis

Yoon H, Kim SG, Kim BK, Shin E, Kim N, Lee HJ, Kang GH, Jung HC

BACKGROUND/AIMS: To evaluate the expression of cellular inhibitor of apoptosis protein 2 (cIAP2) during gastric carcinogenesis after Helicobacter pylori (HP) infection and after HP eradication. METHODS: We divided non-cancer patients into...
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The Association between Helicobacter pylori Infection and Body Weight among Children

Choi JS, Ko KO, Lim JW, Cheon EJ, Lee GM, Yoon JM

PURPOSE: We performed to reveal the association between the Helicobacter pylori infection and body weight among children. METHODS: Out retrospective study included patients who underwent the H. pylori immunoglobulin G testing...
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Efficacy of proton pump inhibitors and H2 blocker in the treatment of symptomatic gastroesophageal reflux disease in infants

Azizollahi HR, Rafeey M

PURPOSE: Gastroesophageal reflux disease (GERD) occurs in pediatric patients when reflux of gastric contents presents with troublesome symptoms. The present study compared the effects of omeprazole and ranitidine for the...
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Oral Proton Pump Inhibitor for Treatment of Congenital Chloride Diarrhea

Jo HC, Yoon JS, Jang JY, Sohn YB, Lee JH, Cheong HI, Park MS

Congenital chloride diarrhea (CCD) is a rare autosomal recessive disease, which is characterized by electrolyte absorption defect due to impaired function of the Cl-/HCO3 - exchanger in the ileum and the...
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Toxic Epidermal Necrolysis in Polymedicated Patient Treated With Radiotherapy

Perez-Calderon R, Gonzalo-Garijo MA, Corrales-Vargas S, Jimenez-Ferrera G, Rodriguez-Nevado I, Diaz-Delgado M

Temozolomide is an oral alkylating agent indicated for the treatment of patients with glioblastoma multiforme concomitantly with radiotherapy and subsequently as monotherapy treatment. We report the case of a patient...
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Protective Effects of Chlorogenic Acid against Experimental Reflux Esophagitis in Rats

Kang JW, Lee SM

Esophageal reflux of gastric contents causes esophageal mucosal damage and inflammation. Recent studies show that oxygen-derived free radicals mediate mucosal damage in reflux esophagitis (RE). Chlorogenic acid (CGA), an ester...
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Trends in the Eradication Rates of Helicobacter pylori Infection in Daegu and Gyeongsangbuk-do, Korea: Multicenter Study over 13 Years

Jung YS, Lee SH, Park CS, Oh MJ, Kim KO, Jang BI, Jeon SW, Jung MK, Park KS, Kim ES, Cho KB, Jung JT, Kwon JG, Kim EY, Kim WJ, Yang CH

BACKGROUND/AIMS: The eradication rates of Helicobacter pylori infection have been reported to have decreased over the years due to antibiotics resistance. The aim of this study is to investigate the...
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Gastroprotective Effect of the Three Glucuronopyranoside Flavonoids in Rats

Im WJ, Nam Y, Park SY, Sohn UD

In this study, we investigated the protective action of glucuronopyranoside flavonoids (QGC, AGC, LGC) on gastritis in rats. QGC, AGC and omeprazole decreased the gastric volume significantly, and each ID50...
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A Randomized, Double Blinded, Clinical Trial to Assess the Efficacy and Cost Effectiveness of Omeprazole Compared to Rabeprazole in the Maintenance Therapy of Patients With Gastroesophageal Reflux Disease

Park JH, Park H, Lee DH, Sung IK

  • KMID: 2325794
  • J Neurogastroenterol Motil.
  • 2013 Apr;19(2):219-226.
BACKGROUND/AIMS: The aim of this study was to evaluate the efficacy and cost efficiency of omeprazole 10 mg and rabeprazole 10 mg once daily for 24 weeks in the maintenance...
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Pharmacokinetics and Pharmacodynamics of the Proton Pump Inhibitors

Shin JM, Kim N

  • KMID: 2325968
  • J Neurogastroenterol Motil.
  • 2013 Jan;19(1):25-35.
Proton pump inhibitor (PPI) is a prodrug which is activated by acid. Activated PPI binds covalently to the gastric H+, K+-ATPase via disulfide bond. Cys813 is the primary site responsible...
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A Study on the Efficacy of Proton Pump Inhibitors in Helicobacter pylori-Negative Primary Care Patients with Dyspepsia in Japan

Kamada T, Fujimura Y, Gotoh K, Imamura H, Manabe N, Kusunoki H, Inoue K, Shiotani A, Hata J, Haruma K

  • KMID: 2053510
  • Gut Liver.
  • 2013 Jan;7(1):16-22.
BACKGROUND/AIMS: There have been few studies on the efficacy of proton pump inhibitors and the doses required to treat dyspeptic symptoms observed in clinical practice. The aim of this study...
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Efficacy of Proton Pump Inhibitor-based Triple Therapy and Bismuth-based Quadruple Therapy for Helicobacter pylori Eradication in Korean Children

Hong J, Yang HR

  • KMID: 2315346
  • Pediatr Gastroenterol Hepatol Nutr.
  • 2012 Dec;15(4):237-242.
PURPOSE: The aim of this study was to assess and compare the efficacies of proton pump inhibitor-based triple therapy and bismuth-based quadruple therapy as first-line treatments for Helicobacter pylori eradication...
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Protective Effect of ECQ on Rat Reflux Esophagitis Model

Jang HS, Han JH, Jeong JY, Sohn UD

This study was designed to determine the protective effect of Rumex Aquaticus Herba extracts containing quercetin-3-beta-D-glucuronopyranoside (ECQ) on experimental reflux esophagitis. Reflux esophagitis was induced by surgical procedure. The rats...
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Apical acidity decreases inhibitory effect of omeprazole on Mg2+ absorption and claudin-7 and -12 expression in Caco-2 monolayers

Thongon N, Krishnamra N

  • KMID: 1401760
  • Exp Mol Med.
  • 2012 Nov;44(11):684-693.
Clinical studies reported hypomagnesaemia in long-term omeprazole usage that was probably due to intestinal Mg2+ wasting. Our previous report demonstrated the inhibitory effect of omeprazole on passive Mg2+ transport across...
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Treatment of Idiopathic Persistent Hiccups with Positive Pressure Ventilation: A Case Report

Byun SH, Jeon YH

A 41-year-old male patient presented with idiopathic persistent hiccups. The hiccups did not respond to pharmacologic treatments including cisapride, omeprazole, and baclofen. Phrenic nerve block was also ineffective. However, the...
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Cow's Milk Allergy among Children with Gastroesophageal Reflux Disease

Farahmand , Najafi M, Ataee P, Modarresi , Shahraki T, Rezaei N

  • KMID: 2284210
  • Gut Liver.
  • 2011 Sep;5(3):298-301.
BACKGROUND/AIMS: Gastroesophageal reflux disease (GERD) and cow's milk allergy (CMA) are two common conditions that occur in infancy. This study was performed to investigate the frequency of CMA in a...
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