Korean J Physiol Pharmacol.  2013 Oct;17(5):411-415. 10.4196/kjpp.2013.17.5.411.

Gastroprotective Effect of the Three Glucuronopyranoside Flavonoids in Rats

• Im WJ
• Nam Y
• Park SY
• Sohn UD

• KMID: 1500235
• DOI: http://doi.org/10.4196/kjpp.2013.17.5.411

Abstract

In this study, we investigated the protective action of glucuronopyranoside flavonoids (QGC, AGC, LGC) on gastritis in rats. QGC, AGC and omeprazole decreased the gastric volume significantly, and each ID50 was 0.75, 0.54 and 8.5 mg/kg, respectively, thus the order of potency was AGC, QGC and omeprazole. They also decreased acid output, and each ID50 was 7.81, 0.58 and 6.71 mg/kg, respectively, thus the order of potency was AGC, omeprazole and QGC. They inhibited gastritis induced by indomethacin, and it recovered significantly by increasing the GSH levels in gastritis. The gastric MPO activity in the gastritis group increased more than in the normal group. QGC, LGC, or AGC administration reduced moderately the MPO activity in a dose-dependent manner. This study demonstrated that AGC, QGC, or LGC showed potent efficacy on the gastritis, by preventing oxidative stress. These results suggest that QGC, AGC, or LGC have gastroprotective effect in rats.

Keyword

Flavonoids; Gastritis; Lipid peroxidation

MeSH Terms

Animals
Flavonoids*
Gastritis
Indomethacin
Lipid Peroxidation
Omeprazole
Oxidative Stress
Rats*
Flavonoids
Indomethacin
Omeprazole

Figure

• 

  Fig. 1 Chemical structures of QGC, AGC and LGC.

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  Fig. 2 The effect of QGC, LGC, AGC and omeprazole on gastritis. Data are expressed as mean±SEM.

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  Fig. 3 The effect of QGC, LGC, AGC and omeprazole on glutathione levels in gastritis. In the control gastritis group, the glutathione levels were significantly lower than the levels in the normal group. However, QGC, LGC, or AGC administration recovered the GSH levels. Data are expressed as means±S.E.M, n=6~8. **p<0.01 compared with each normal value. #p<0.05, ##p<0.01 compared with each control group.

• 

  Fig. 4 Inhibitory effects of QGC, LGC, AGC and omeprazole on myeloperoxidase levels in gastritis. In the gastritis group, the gastric MPO activity significantly increased than the normal group. QGC, LGC, or AGC administration reduced the MPO activity in a dose-dependent manner. Data are expressed as means±S.E.M, n=7. **p<0.01 compared with each normal value. #p<0.05, ##p<0.01 compared with each control group.

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