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Quantitative Structure Activity Relationship between Diazabicyclo[4.2.0]octanes Derivatives and Nicotinic Acetylcholine Receptor Agonists

Kim EA, Jung KC, Sohn UD, Im C

Three dimensional quantitative structure activity relationship between diazabicyclo[4.2.0]octanes and nicotinic acetylcholine receptor (h alpha4beta2 and h alpha3beta4) agonists was studied using comparative molecular field analysis (CoMFA) and comparative molecular similarity...
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Improved motility in the gastrointestinal tract of a postoperative ileus rat model with ilaprazole

Kim GM, Sohn HJ, Choi WS, Sohn UD

Postoperative ileus (POI), a symptom that occurs after abdominal surgery, reduces gastrointestinal motility. Although its mechanism is unclear, POI symptoms are known to be caused by inflammation 6 to 72...
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Gastroprotective Effect of the Three Glucuronopyranoside Flavonoids in Rats

Im WJ, Nam Y, Park SY, Sohn UD

In this study, we investigated the protective action of glucuronopyranoside flavonoids (QGC, AGC, LGC) on gastritis in rats. QGC, AGC and omeprazole decreased the gastric volume significantly, and each ID50...
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Autophagy and Digestive Disorders: Advances in Understanding and Therapeutic Approaches

Thein W, Po WW, Choi WS, Sohn UD

The gastrointestinal (GI) tract is a series of hollow organs that is responsible for the digestion and absorption of ingested foods and the excretion of waste. Any changes in the...
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The Inhibitory Effect of Quercetin-3-O-beta-D-Glucuronopyranoside on Gastritis and Reflux Esophagitis in Rats

Min YS, Lee SE, Hong ST, Kim HS, Choi BC, Sim SS, Whang WK, Sohn UD

It was evaluated the inhibitory action of quercetin-3-O-beta-D-glucuronopyranoside (QGC) on reflux esophagitis and gastritis in rats. QGC was isolated from the herba of Rumex Aquaticus. Reflux esophagitis or gastritis was...
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Inhibitory effect of quercetin and desferrioxamine in rat reflux esophagitis

Song HJ, Kil BJ, Kim IW, Min YS, Kim DS, Sohn UD

  • KMID: 2071571
  • Korean J Physiol Pharmacol.
  • 2001 Aug;5(4):315-321.
This study was aimed to evaluate the effects of quercetin and desferrioxamine on the development of the reflux esophagitis induced surgically, on gastric secretion and on lipid peroxidation which is a marker of...
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The Inhibitory Mechanism of Gentamicin on Electrical Field Stimulation Response in Rat Bladder Smooth Muscle

Min CH, Wang Y, Bae J, Han JH, Sohn UD

To see the inhibitory mechanism of gentamicin in response to electrical field stimulation (EFS) using the rat bladder smooth muscle, atropine or guanethidine was treated but had no effect. Methylsergide,...
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Survey of Correlations on the Drug Use Patterns between Children and Their Parents

Hwang MY, Bang JS, Sohn UD

BACKGROUND: It is thought that drug use of parents is related to that of young children. The status of drug among young children's parents and a correlation of with parents...
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Comparison of Ectopic Gene Expression Methods in Rat Neural Stem Cells

Kim W, Kim JH, Kong SY, Park MH, Sohn UD, Kim HJ

Neural stem cells (NSCs) have the ability to proliferate and differentiate into various types of cells that compose the nervous system. To study functions of genes in stem cell biology,...
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Effects of the Combination of Evogliptin and Leucine on Insulin Resistance and Hepatic Steatosis in High-Fat Diet-Fed Mice

Shin CY, Lee HY, Kim GH, Park SY, Choi WS, Sohn UD

In this study, we aimed to investigate the effects of 8 weeks of treatment with a combination of evogliptin and leucine, a branchedchain amino acid, in mice with high-fat diet...
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Cytotoxic Activity and Structure Activity Relationship of Ceramide Analogues in Caki-2 and HL-60 Cells

Kim YJ, Kim EA, Sohn UD, Yim CB, Im C

B13, a ceramide analogue, is a ceramidase inhibitor and induces apoptosis to give potent anticancer activity. A series of thiourea B13 analogues was evaluated for their in vitro cytotoxic activities...
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Intestinal Absorption of Fibrinolytic and Proteolytic Lumbrokinase Extracted from Earthworm, Eisenia andrei

Yan XM, Kim CH, Lee CK, Shin JS, Cho IH, Sohn UD

To investigate the intestinal absorption of a fibrinolytic and proteolytic lumbrokinase extracted from Eisenia andrei, we used rat everted gut sacs and an in situ closed-loop recirculation method. We extracted...
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Anti-Oxidative and Anti-Inflammatory Effects of QGC in Cultured Feline Esophageal Epithelial Cells

Lee MJ, Song HJ, Jeong JY, Park SY, Sohn UD

Quercetin-3-O-beta-D-glucuronopyranoside (QGC) is a flavonoid glucoside extracted from Rumex Aquaticus Herba. In the present study, anti-oxidative and anti-inflammatory effects of QGC were tested in vitro. Epithelial cells obtained from cat...
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The Altered Signaling on EFS-Induced Colon Contractility in Diabetic Rats

Thein W, Po WW, Kim DM, Sohn UD

Diabetes mellitus affects the colonic motility developing gastrointestinal symptoms, such as constipation. The aim of the study was to examine the role of intracellular signaling pathways contributing to colonic dysmotility...
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The Effect of Luteolin on the Modulation of Vascular Contractility via ROCK and CPI-17 Inactivation

Yoon HJ, Kang DH, Jin F, Bang JS, Sohn UD, Je HD

In this investigation, we made a study of the efficacy of luteolin (a flavonoid found in plants such as vegetables, herbs and fruits) on vascular contractibility and to elucidate the...
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Morinda citrifolia Inhibits Both Cytosolic Ca2+-dependent Phospholipase A2 and Secretory Ca2+-dependent Phospholipase A2

Song HS, Park SH, Ko MS, Jeong JM, Sohn UD, Sim SS

This study investigated the effects of the methanol extracts of Morinda citrifolia containing numerous anthraquinone and iridoid on phospholipase A2 (PLA2) isozyme. PLA2 activity was measured using various PLA2 substrates,...
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The hyperthermic effect of nitric oxide in central nervous system

Jung JK, Sohn UD, Lee SY

  • KMID: 1606844
  • Korean J Physiol Pharmacol.
  • 2001 Feb;5(1):93-98.
The precise mechanism of set-point regulation in hypothalamus was not elucidated. Nitric oxide synthases (NOS) were detected in hypothalamus, however, the roles of NO in hypothalamus was not fully studied. So, we tested...
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The hepato-protective effect of eupatilin on an alcoholic liver disease model of rats

Lee HY, Nam Y, Choi WS, Kim TW, Lee J, Sohn UD

Eupatilin is known to possess anti-apoptotic, anti-oxidative, and antiinflammatoryproperties. We report here that eupatilin has a protective effect onthe ethanol-induced injury in rats. Sprague–Dawley rats were divided into 6 groups:control,...
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Anti-Inflammatory and Anti-Superbacterial Properties of Sulforaphane from Shepherd's Purse

Choi WJ, Kim SK, Park HK, Sohn UD, Kim W

Shepherd's purse, Capsella bursa-pastoris (L.) Medik., has been considered a health food for centuries in Asia and is known to contain the isothiocyanate compound sulforaphane. In this study, we evaluated...
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Endothelium-Independent Effect of Fisetin on the Agonist-Induced Regulation of Vascular Contractility

Je HD, Sohn UD, La HO

Fisetin, a natural flavonoid found in a variety of vegetables and fruits, has been shown to possess many biological functions. The present study was undertaken to investigate the influence of...
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