Biomol Ther.  2015 Sep;23(5):458-464. 10.4062/biomolther.2015.052.

Gastroprotective Activities of Sennoside A and Sennoside B via the Up-Regulation of Prostaglandin E2 and the Inhibition of H+/K+-ATPase

• Hwang IY
• Jeong CS

• KMID: 2380295
• DOI: http://doi.org/10.4062/biomolther.2015.052

Abstract

Sennoside A (erythro) and sennoside B (threo) are dianthrone glycosides and diastereomers. We investigated their abilities to prevent the gastric lesions associated with diseases, such as, gastritis and gastric ulcer. To elucidate their gastroprotective effects, the inhibitions of HCl*EtOH-induced gastritis and indomethacin-induced gastric ulcers were assessed in rats. It was observed that both sennoside A and sennoside B increased prostaglandin E2 (PGE2) levels and inhibited H+/K+-ATPase (proton pump). In a rat model, both compounds reduced gastric juice, total acidity and increased pH, indicating that proton pump inhibition reduces gastric acid secretion. Furthermore, sennoside A and B increased PGE2 in a concentration-dependent manner. In a gastric emptying and intestinal transporting rate experiment, both sennoside A and sennoside B accelerated motility. Our results thus suggest that sennoside A and sennoside B possess significant gastroprotective activities and they might be useful for the treatment of gastric disease.

Keyword

Sennoside A; Sennoside B; Prostaglandin E2; H+/K+-ATPase; Gastric lesion

MeSH Terms

Animals
Dinoprostone*
Gastric Acid
Gastric Emptying
Gastric Juice
Gastritis
Glycosides
Hydrogen-Ion Concentration
Models, Animal
Proton Pumps
Rats
Stomach Diseases
Stomach Ulcer
Up-Regulation*
Dinoprostone
Glycosides
Proton Pumps