Biomol Ther.  2015 Jan;23(1):53-59. 10.4062/biomolther.2014.103.

Protective Effect of Liriodendrin Isolated from Kalopanax pictus against Gastric Injury

• Sohn YA
• Hwang SA
• Lee SY
• Hwang IY
• Kim SW
• Kim SY
• Moon A
• Lee YS
• Kim YH
• Kang KJ
• Jeong CS

• KMID: 2380363
• DOI: http://doi.org/10.4062/biomolther.2014.103

Abstract

In this study, we investigated the inhibitory activities on gastritis and gastric ulcer using liriodendrin which is a constituent isolated from Kalopanax pictus. To elucidate its abilities to prevent gastric injury, we measured the quantity of prostaglandin E2 (PGE2) as the protective factor, and we assessed inhibition of activities related to excessive gastric acid be notorious for aggressive factor and inhibition of Helicobacter pylori (H. pylori) colonization known as a cause of chronic gastritis, gastric ulcer, and gastric cancer. Liriodendrin exhibited higher PGE2 level than rebamipide used as a positive control group at the dose of 500 microM. It was also exhibited acid-neutralizing capacity (10.3%) and H+/K+-ATPase inhibition of 42.6% (500 microM). In pylorus-ligated rats, liriodendrin showed lower volume of gastric juice (4.38 +/- 2.14 ml), slightly higher pH (1.53 +/- 0.41), and smaller total acid output (0.47 +/- 0.3 mEq/4 hrs) than the control group. Furthermore liriodendrin inhibited colonization of H. pylori effectively. In vivo test, liriodendrin significantly inhibited both of HCl/EtOH-induced gastritis (46.9 %) and indomethacin-induced gastric ulcer (46.1%). From these results, we suggest that liriodendrin could be utilized for the treatment and/or protection of gastritis and gastric ulcer.

Keyword

Liriodendrin; Prostaglandin E2; H+/K+-ATPase; Gastritis; Gastric ulcer

MeSH Terms

Animals
Colon
Dinoprostone
Gastric Acid
Gastric Juice
Gastritis
Helicobacter pylori
Hydrogen-Ion Concentration
Kalopanax*
Rats
Stomach Neoplasms
Stomach Ulcer
Dinoprostone