Nat Prod Sci.  2020 Dec;26(4):268-278. 10.20307/nps.2020.26.4.268.

Chemical Composition of Artemisia argyi Extract (RW0117) and Protective Effects against Gastric Lesions in vivo

• Lee JW
• Park SH
• Jegal CM
• Choi KY
• Jung HY
• Choi JA
• Lee CK
• Kim HK
• Lee JS
• Lee IK

• KMID: 2511944
• DOI: http://doi.org/10.20307/nps.2020.26.4.268

Abstract

In this study, we investigated the chemical profile and effects of RW0117 (Artemisia argyi 65 .5 % ethanol extract) on gastric lesions in rats. We optimized and validated a method to obtain the chemical profile of RW0117. We then investigated the antioxidant and anti-inflammatory effects in vivo, and the protective effects on gastric lesions in vivo. The IC₅₀ of 2,2-diphenyl-1-picrylhydrazyl free radical scavenging considering the antioxidant effects of RW0117 was 166.55 μg/mL, and the IC₅₀ of nitric oxide scavenging considering the antiinflammatory effects was 41.16 μg/mL. Oral administration of RW0117 at lower concentrations (25, 50, 100 mg/ kg) had similar or greater effects than the daily intake conversion concentration (115mg/kg) of a health functional food (Avexol^® ) in the acetic acid-induced ulcer and the ethanol-induced gastric injury rat models. In addition, oral administration of RW0117 increased the expression of prostaglandin E₂ , which enhances the protective effect in the gastric mucosa in the ethanol-induced gastric injury rat model. These results suggest that RW0117 may have potential therapeutic uses in the protection of the gastric mucosa.

Keyword

RW0117; Artemisia argyi; Chemical profile; Gastric ulcer; Caffeoylquinic acids; Flavonoids