J Bacteriol Virol.  2007 Sep;37(3):129-136. 10.4167/jbv.2007.37.3.129.

Chemical Composition and Antibacterial Activity Against Oral Bacteria by the Essential Oil of Artemisia iwayomogi

• Cha JD

• KMID: 1513567
• DOI: http://doi.org/10.4167/jbv.2007.37.3.129

Abstract

The aerial part of Artemisia iwayomogi KITAMURA has traditionally been used for antitumour, immunomodulating, antimutagenic, antioxidant, antibacterial, antifungal, antipyretic, diuretic, liver protective effect, and choleretic purposes in Korea. The chemical composition of the essential oil obtained from A. iwayomogi was analyzed by GC/MS. The essential oil and its major compounds were tested for antibacterial activities against 15 different genera of oral bacteria. The essential oil of A. iwayomogi was rich in camphor (17.96%), 1,8-cineole (14.79%), terpinen-4-ol (3.28%), alpha-terpineol (17.60%), and beta-caryophyllene (4.05%). The essential oil of A. iwayomogi exhibited considerable inhibitory effects against all obligate anaerobic bacteria (MICs, 0.05 to 0.2 mg/ml; MBCs, 0.1 to 0.4 mg/ml) tested, while its major compounds demonstrated various degrees of growth inhibition.

Keyword

Artemisia iwayomogi; Essential oil; Antibacterial activity; Minimum inhibitory concentrations/Minimum bactericidal concentrations (MICs/MBCs)

MeSH Terms

Artemisia*
Bacteria*
Bacteria, Anaerobic
Camphor
Korea
Liver
Camphor

Figure

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  Figure 1. Gas chromatography/mass spectrometric analysis of the essential oil obtained from Artemisia iwayomogi

Reference

References

1). Ahn H, Kim JY, Lee HJ, Kim YK, Ryu JH. In-hibitors of inducible nitric oxide synthase expression from Artemisia iwayomogi. Arch Pharm Res. 26:301–305. 2003.

2). Bae JM, Kim MS, Park HJ, Chung HY, Young H, Park KY, Moon SH, Choi JS. Antimutagenic principle of Artemisia iwayomogi and its action mechanism. J Kor Cancer Assoc. 24:352–358. 1992.

3). Beldjoudi N, Mambu L, Labaied M, Grellier P, Ramanitrahasimbola D, Rasoanaivo P, Martin MT, Frappier F. Flavonoids from Dalbergia louvelii and their antiplasmodial activity. J Nat Prod. 66:1447–1450. 2003.

4). Cha JD, Jeong MR, Choi HJ, Jeong SI, Moon SE, Yun SI, Kim YH, Kil BS, Song YH. Chemical composition and antimicrobial activity of the essential oil of Artemisia lavandulaefolia. Planta Med. 71:575–577. 2005.

5). Cha JD, Jeong MR, Jeong SI, Moon SE, Kim JY, Kil BS, Song YG. Chemical composition and antimicrobial activity of the essential oils of Artemisia scoparia and A. capillaris. Planta Med. 71:186–190. 2005.

6). Crowell PL. Prevention and therapy of cancer by dietary monoterpenes. Nutrition. 129:775–778. 1999.

7). Faid M, Bakhy K, Anchad M, Tantaoui-Elaraki A. Almond paste: Physicochemical and microbiological characterizations and preservations with sorbic acid and cinnamon. J Food Prot. 58:547–550. 1995.

8). Guardia T, Juarez AO, Guerreiro E, Guzman JA, Pelzer L. Antiinflammatory activity and effect on gastric acid secretion of dehydroleucodine isolated from Artemisia douglasiana. J Ethnopharmacol. 88:195–198. 2003.

9). Hammer KA, Dry L, Johnson M, Michalak EM, Carson CF, Riley TV. Susceptibility of oral bacteria to Melaleuca alternifolia (tea tree) oil in vitro. Oral Microbiol Immunol. 18:389–392. 2003.

10). Huang W, Zhang J, Moore DD. A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. J Clin Invest. 113:137–143. 2004.

11). Hwang JS, Chung HK, Bae EK, Lee AY, Ji HJ, Park DW, Jung HJ, Cho CW, Choi HJ, Lee DS, Lee KR, Youn HJ. The polysaccharide fraction AIP1 from Artemisia iwayomogi suppresses apoptotic death of the mouse spleen cells in culture. Arch Parm Res. 26:294–300. 2003.

12). Jain SK, Agrawal SC. Fungistatic activity of some perfumes against otomycotic pathogens. Mycoses. 45:88–90. 2002.

13). Juteau F, Jerkovic I, Masotti V. Composition and antimicrobial activity of the essential oil of Artemisia absinthium from Croatia and France. Planta Med. 69:158–161. 2003.

14). Katz N, dos Santos Filho D, Sarti SJ, Mendes NM, Rocha Filho PA, Araujo N. Chemoprophylactic activity on Schistosomiasis mansoni of soaps containing essential oil from the fruits of Pterodon pubescens. Rev Inst Med Trop Sao Paulo. 35:183–191. 1993.

15). Kim KJ, Kim YH, Yu YH, Jeong SI, Cha JD, Kil BS, You YO. Antibacterial activity and chemical composition of essential oil of Chrysnathemum boreale. Planta Med. 69:274–277. 2003.

16). Kim SS, Lee CK, Kang SS, Jung HA, Choi JS. Chlorogenic acid an antioxidant principle from the aerial parts of Artemisia iwayomogi that acts on 1,1-diphenyl-2-picrylhydrazyl radical. Arch Pharm Res. 20:148–154. 1997.

17). Koo KA, Kwak JH, Lee KR, Zee OP, Woo ER, Park HK, Youn HJ. Antitumor and immunomodulating activities of the polysaccharide fractions from Artemisia slengenesis and Artemisia iwayomogi. Arch Pharm Res. 17:371–374. 1994.

18). Kordali S, Kotan R, Mavi A, Cakir A, Ala A, Yildirim A. Determination of the chemical composition and antioxidant activity of the essential oil of Artemisia dracunculus and of the antifungal and antibacterial activities of Turkish Artemisia absinthium, A. dracunculus, Artemisia santonicum, and Artemisia spicigera essential oils. J Agric Food Chem. 53:9452–9458.

19). Lee SB, Cho TS, Yoon KW, Lee JC, Lee SM, Shim SB. Astudy on the hepatoprotective effect of PS-1 from Artemisia iwayomogi. J Appl Pharmacol. 6:119–129. 1998.

20). Lee SH, Lee MY, Kang HM, Han DC, Son KH, Yang DC, Sung ND, Lee CW, Kim HM, Kwon BM. Antitumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisia. Bioorg. Med Chem. 11:4545–4549. 2003.

21). Li H, Madden JL, Potts BM. Variation in volatile leaf oils of the Tasmanian Eucalyptus species. 1. Subgenus Monocalyptus. Biochem Syst Ecol. 23:299–318. 1995.

22). Mangena T, Muyima NY. Comparative evaluation of the antimicrobial activities of essential oils of Artemisia afra, Pteronia incana, and Rosmarinus officinalis on selected bacteria and yeast strains. Lett Appl Microbiol. 28:291–296. 1999.

23). Sadraei H, Asghari GR, Hajhashemi V, Kolagar A, Ebrahimi M. Spasmolytic activity of essential oil and various extracts of Ferula gummosa Boiss. on ileum contractions. Phytomedicine. 8:370–376. 2001.

24). Santoyo S, Cavero S, Jaime L, Ibanez E, Senorans FJ, Reglero G. Chemical composition and antimicrobial activity of Rosmarinus officinalis L. essential oil obtained via supercritical fluid extraction. J Food Prot. 68:790–795. 2005.

25). Shunying Z, Yang Y, Huaidong Y, Yue Y, Guolin Z. Chemical composition and antimicrobial activity of the essential oils of Chrysanthemum indicum. J Ethnopharmacol. 96:151–158. 2005.

26). Tan RX, Zheng WF, Tang HQ. Biologically active substances from the genus Artemisia. Planta Med. 64:295–302. 1998.

27). Uluelen A, Toqcu G, Eris C. Terpenoids from Salva sclarea. Phytochemistry. 36:971–974. 1994.

28). Viljoen A, van Vuuren S, Ernst E, Klepser M, Demirci B, Baser H, van Wyk BE. Osmitopsis asteriscoides (Asteraceae)-the antimicrobial activity and essential oil composition of a Cape-Dutch remedy. J Ethnopharmacol. 88:137–143. 2003.

29). Wang YC, Huang TL. Screening of anti-Helicobacter pylori herbs deriving from Taiwanese folk medicinal plants. FEMS Immunol Med Microbiol. 43:295–300. 2005.

30). Yu HH, Kim YH, Kil BS, Kim KJ, Jeong SI, You YO. Chemical composition and antibacterial activity of essential oil of Artemisia iwayomogi. Planta Med. 69:1159–1162. 2003.