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Risk factors for early gastric cancer: focus on Helicobacter pylori gastritis

Moon HS

Background: Gastric cancer is a global health problem, and the incidence and geographical distribution of different types of gastric cancer varies. Particularly, noncardiac gastric cancer is more prevalent in East...
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Tauroursodeoxycholic Acid Inhibits Nuclear Factor Kappa B Signaling in Gastric Epithelial Cells and Ameliorates Gastric Mucosal Damage in Mice

Kim SH, Kim JW, Koh SJ, Kim SG, Bae JM, Kim JH, Park JH, Chang MS, Choi KD, Kang HW, Kim BG, Lee KL

Background/Aims: Previous studies have reported the protective effects of tauroursodeoxycholic acid (TUDCA) on gastric epithelial cells in some animal models, but the precise mechanisms are unclear. This study examined the...
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Incidence of Infection among Subjects with Helicobacter pylori Seroconversion

Kim YJ, Lee SY, Kim JH, Sung IK, Park HS

Background/Aims: Helicobacter pylori (H. pylori) seroconversion may occur during screening for gastric cancer. Our study aimed to assess the number of seroconverted subjects with H. pylori and their results in...
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Steamed Ginger Extract Exerts Anti-inflammatory Effects in Helicobacter pylori-infected Gastric Epithelial Cells through Inhibition of NF-κB

Song MY, Lee DY, Park SY, Seo SA, Hwang J, Heo SH, Kim EH

Ginger (Zingiber officinale) has traditionally been used as a treatment for inflammatory diseases in the Asian region. Recently, anti-inflammatory effects of steamed ginger extract (GGE03) have been reported, but its...
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Efficacy and Safety of Rebamipide versus Its New Formulation, AD-203, in Patients with Erosive Gastritis: A Randomized, DoubleBlind, Active Control, Noninferiority, Multicenter, Phase 3 Study

Kim GH, Lee HL, Joo MK, Park HJ, Jung SW, Lee OJ, Kim H, Chun HJ, Lee ST, Kim JW, Jeon HH, Chung IK, Kim HS, Lee DH, Kim KO, Lim YJ, Park SJ, Cho SJ, Kim BW, Ko KH, Jeon SW, Kim JG, Sung IK, Kim TN, Sung JK, Park JJ

Background/Aims: The mucoprotective drug rebamipide is used to treat gastritis and peptic ulcers. We compared the efficacy of Mucosta Ⓡ (rebamipide 100 mg) and its new formulation, AD-203 (rebamipide 150...
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Correlation between Gastroscopy Findings and Pepsinogen Values

Yoon DI, Choi M, Yoon YJ, Lee HK, Cho SJ, Kim WJ, Kim JH

Background: If the pepsinogen (PG) level could indicate the condition of the gastric mucosa, it can rapidly diagnose atrophic gastritis, a high risk factor for stomach cancer. Based on varying...
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Five Autoimmune Gastritis Patients with Positive Findings of Serum Anti-parietal Cell Antibodies

Jeong JH, Lee SY, Han HS, Kim JH, Sung IK, Park HS

Autoimmune gastritis is a corpus-dominant type of gastritis with positive serum anti-parietal cell antibodies (APCA) and/or anti-intrinsic factor antibodies. Serum APCA and pepsinogen (PG) assays were performed in subjects with...
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Bile Reflux Gastropathy and Functional Dyspepsia

  • KMID: 2517534
  • J Neurogastroenterol Motil.
  • 2021 Jul;27(3):400-407.
  • doi: 10.5056/jnm20102
Background/Aims The pathoetiology of functional dyspepsia remains unclear; one mechanism could be chemical gastropathy from chronic bile reflux. We aim to examine the association of bile reflux gastropathy with functional dyspepsia and...
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Protective Effects of Silibinin on Helicobacter pyloriinduced Gastritis: NF-κB and STAT3 as Potential Targets

Cho K, Lee HG, Piao JY, Kim SJ, Na HK, Surh YJ

More than half of the world’s populations are considered to be infected by Helicobacter pylori. It causes a chronic inflammation of the stomach, which is implicated in the pathogenesis of...
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Effect of Helicobacter pylori Eradication on the Prevention of Gastric Cancer in the General Population with or without Precancerous Lesions: A Meta-analysis

Kang SJ, Shin CM, Kang SJ

  • KMID: 2509974
  • J Dig Cancer Res.
  • 2020 Dec;8(2):81-90.
We performed a comprehensive meta-analysis on whether Helicobacter pylori (H. pylori) eradication can prevent gastric cancer in individuals with precancerous lesions (chronic atrophic gastritis, intestinal metaplasia, and dysplasia). The studies...
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Endoscopic Prediction for Acid Reflux in Patients without Hiatus Hernia

Kim JY, Shin IS, Min YW, Kim K, Lee H, Min BH, Lee JH, Kim JJ, Rhee PL

Background/Aims: A diagnosis of gastroesophageal reflux disease is challenging in patients who have reflux symptoms but do not respond to proton pump inhibitors nor have reflux esophagitis and hiatal hernia...
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Alternations of Gastric Microbiota with Mucosal Atrophy and Intestinal Metaplasia

Shin CM

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Corrosive Esophagitis and Gastritis Induced by Glutaraldehyde Ingestion

Jun D, Kim HJ, Lee HS, Yoon HJ, Park JY, Kim BJ, Kim JG

Corrosive esophagitis and gastritis are characterized by caustic damage due to ingestion of chemical agents. Caustic agents cause tissue destruction through liquefaction or coagulation reactions. Here, we report a case...
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Significance of Helicobacter pylori Eradication on Atrophic Gastritis and Intestinal Metaplasia

Yoon K, Kim N

There has been an accumulation of data regarding the chemopreventive effects of Helicobacter pylori (H. pylori) eradication. However, it remains unclear how H. pylori infection causes gastric cancer (GC) and...
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Natural Course of Atrophic Gastritis and Intestinal Metaplasia

Kim BJ

Atrophic gastritis (AG) and intestinal metaplasia (IM) are considered the main precursor lesions of gastric cancer, and the risk of gastric cancer in the gastric mucosa increases in the presence...
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Endoscopic Diagnosis and Classification of Atrophic Gastritis and Intestinal Metaplasia

Jeon SW

Gastritis is the term used to describe the inflammatory condition of the stomach. However, the ambiguous application of this term in clinical practice, such as in endoscopic or histological diagnosis,...
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Anti-microbial and anti-inflammatory effects of Cheonwangbosim-dan against Helicobacter pylori-induced gastritis

Park HS, Jeong HY, Kim YS, Seo CS, Ha H, Kwon HJ

Background: There are various Helicobacter species colonizing the stomachs of animals. Although Helicobacter species usually cause asymptomatic infection in the hosts, clinical signs can occur due to gastritis associated with...
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Emphysematous Gastritis Worsened after Upper Endoscopy

Kim TU, Kim SJ, Ryu H, Kim JH, Jang JY, Yeom JA, Roh J, Jeong HS, Park BS, Kim DI

Emphysematous gastritis is an infectious disease in which air is formed in the gastric wall by gas-forming organisms. It is infrequently reported but can be fatal without early diagnosis and...
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Phlegmonous Gastritis Caused by Penetration of a Toothpick

Rim CB, Kim SM

Phlegmonous gastritis is a disease caused by a bacterial infection of the gastric wall. This condition is rare, but when it does occur, its prognosis appears to be poor. The...
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Effect of Citric Acid on Accuracy of ¹³C-Urea Breath Test after Helicobacter pylori Eradication Therapy in a Region with a High Prevalence of Atrophic Gastritis

Kwon YH, Kim N, Yoon H, Shin CM, Park YS, Lee DH

BACKGROUND/AIMS: The validity of ¹³C-urea breath test (¹³C-UBT) for Helicobacter pylori detection is influenced by atrophic gastritis. The aim of this study was to evaluate the effect of citric acid...
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