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Anti-inflammatory effect of aged black garlic on 12-O-tetradecanoylphorbol-13-acetate-induced dermatitis in mice

You BR, Yoo JM, Baek SY, Kim MR

BACKGROUND/OBJECTIVES: Although aged black garlic has various biological activities such as anti-allergy, anti-inflammation and neuroprotection, effect of aged black garlic on chemically contact dermatitis is unclarified. MATERIALS/METHODS: To evaluate anti-dermatitic activity...
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Inflammatory Effect of Light-Emitting Diodes Curing Light Irradiation on Raw264.7 Macrophage

Jeong MJ, Kil KS, Lee MH, Lee SY, Lee HJ, Lim DS, Jeong SJ

BACKGROUND: The light-emitting diode (LED) curing light used is presumed to be safe. However, the scientific basis for this is unclear, and the safety of LED curing light is still...
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Propofol Suppresses LPS-Induced Inflammation in Amnion Cells via Inhibition of NF-κB Activation

Yoon JY, Kim DW, Ahn JH, Choi EJ, Kim YH, Jeun M, Kim EJ

BACKGROUND: Preterm labor is a leading risk factor for neonatal death and long-term impairment and linked closely with inflammation. Non-obstetric surgery is occasionally needed during pregnancy and the anesthetic drugs...
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Effects of the cathepsin K inhibitor with mineral trioxide aggregate cements on osteoclastic activity

Kim HS, Kim S, Ko H, Song M, Kim M

OBJECTIVES: Root resorption is an unexpected complication after replantation procedures. Combining anti-osteoclastic medicaments with retrograde root filling materials may avert this resorptive activity. The purpose of this study was to...
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Biological Effects of Light-Emitting Diodes Curing Unit on MDPC-23 Cells and Lipopolysaccharide Stimulated MDPC-23 Cells

Jeong MJ, Jeong SJ

BACKGROUND: Light-emitting diodes curing unit (LCU), which emit blue light, is used for polymerization of composite resins in many dentistry. Although the use of LCU for light-cured composite resin polymerization...
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Reduction of Inflammation and Enhancement of Motility after Pancreatic Islet Derived Stem Cell Transplantation Following Spinal Cord Injury

Karaoz E, Tepekoy F, Yilmaz I, Subasi C, Kabatas S

OBJECTIVE: Spinal cord injury (SCI) is a very serious health problem, usually caused by a trauma and accompanied by elevated levels of inflammation indicators. Stem cell-based therapy is promising some...
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Effects of remifentanil preconditioning on factors related to uterine contraction in WISH cells

Kim CH, Lee SH, Kim EJ, Ahn JH, Choi EJ, Yoon JU, Choi IS

BACKGROUND: Preterm labor and miscarriage may occur in stressful situations, such as a surgical operation or infection during pregnancy. Pharyngeal and buccal abscess and facial bone fractures are inevitable dental...
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Hyaluronic acid has chondroprotective and joint-preserving effects on LPS-induced synovitis in horses

Neuenschwander HM, Moreira JJ, Vendruscolo CP, Fülber J, Seidel SR, Michelacci YM, Baccarin R

The intra-articular use of hyaluronic acid (HA) for the treatment of synovitis and osteoarthritis is still controversial. As a consequence, corticosteroids remain the most frequently employed therapeutic agents, despite their...
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Outcomes of ‘one-day trial of vaginal delivery of twins’ at 36–37 weeks' gestation in Japan

Haruna Y, Suzuki S

OBJECTIVE: The lack of obstetricians in Japan has prevented the implementation of a 24–hour delivery monitoring system for high-risk deliveries such as twin vaginal delivery at many obstetric facilities. To...
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Complementary Participation of Genetics and Epigenetics in Development of NSAID-exacerbated Respiratory Disease

Lee JU, Park JS, Chang HS, Park CS

Nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NERD) has attracted a great deal of attention because of its association with severe asthma. However, it remains widely underdiagnosed in asthmatics as well...
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Anti-inflammatory effect of remifentanil in lipopolysaccharide–stimulated amniotic epithelial cells

Kim CH, Jeong SS, Park SJ, Choi EJ, Kim YH, Ahn JH

BACKGROUND: Sometimes general anesthesia is required for dental surgery in pregnant women. Facial bone fractures or neck abscess should be treated immediately. Dental surgery, however, creates a stressful situation that...
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Roles of Mesenchymal Stem Cells in Tissue Regeneration and Immunomodulation

Ayala-Cuellar AP, Kang JH, Jeung EB, Choi KC

Mesenchymal stem cells are classified as multipotent stem cells, due to their capability to transdifferentiate into various lineages that develop from mesoderm. Their popular appeal as cell-based therapy was initially...
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Diallyl Trisulfide Suppresses the Production of Lipopolysaccharide-induced Inflammatory Mediators in BV2 Microglia by Decreasing the NF-κB Pathway Activity Associated With Toll-like Receptor 4 and CXCL12/CXCR4 Pathway Blockade

Lee HH, Jeong JW, Hong SH, Park C, Kim BW, Choi YH

BACKGROUND: Diallyl trisulfide (DATS), a garlic-derived organosulfuric compound, has been documented for potential anti-inflammatory effects. However, the mechanism in microglia remains unknown. In this study, we investigated the anti-inflammatory effects...
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Therapeutic Efficacy of Mesenchymal Stem Cells and Mesenchymal Stem Cells-derived Neural Progenitors in Experimental Autoimmune Encephalomyelitis

Nasri F, Mohtasebi , Hashemi E, Zarrabi M, Gholijani , Sarvestani EK

BACKGROUND AND OBJECTIVES: The goal of treatment for MS is to reduce the inflammation and induce the regeneration of degenerated axons. Considering the anti-inflammatory and regenerative capacity of mesenchymal stem...
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Synthetic 3′,4′-Dihydroxyflavone Exerts Anti-Neuroinflammatory Effects in BV2 Microglia and a Mouse Model

Kim N, Yoo HS, Ju YJ, Oh MS, Lee KT, Inn KS, Kim NJ, Lee JK

Neuroinflammation is an immune response within the central nervous system against various proinflammatory stimuli. Abnormal activation of this response contributes to neurodegenerative diseases such as Parkinson disease, Alzheimer’s disease, and...
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Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish

Jeong JW, Cha HJ, Han MH, Hwang SJ, Lee DS, Yoo JS, Choi IW, Kim S, Kim HS, Kim GY, Hong SH, Park C, Lee HJ, Choi YH

Spermidine is a naturally occurring polyamine compound that has recently emerged with anti-aging properties and suppresses inflammation and oxidation. However, its mechanisms of action on anti-inflammatory and antioxidant effects have...
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Effects of salmon DNA fraction in vitro and in a monosodium iodoacetate-induced osteoarthritis rat model

Ra HJ, Oh MY, Kim HJ, Lee SY, Eom DW, Lee SK, Kim SN, Chung KS, Jang HJ

PRF001 is a fragmented DNA polymer extracted from the testes of salmon. The purpose of this study was to assess the anti-inflammatory effect of PRF001 in vitro as well as...
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Expression of Prostaglandin E2 Receptors in Acquired Middle Ear Cholesteatoma

Wang S, Xie L, Zhang Y, Xu P, Liu A

OBJECTIVES: To investigate the expression of prostaglandin E2 receptor subtypes, E-prostanoid (EP) 1–4 receptors, in acquired cholesteatoma and its possible role in the pathologic process of this disorder. METHODS: Specimens of...
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6-Shogaol reduces progression of experimental endometriosis in vivo and in vitro via regulation of VGEF and inhibition of COX-2 and PGE2-mediated inflammatory responses

Wang D, Jiang Y, Yang X, Wei Q, Wang H

Endometriosis (EM) is one of the most common gynaecological disorder affecting women in their reproductive age. Mechanisms involved in the pathogenesis of EM remains poorly understood, however inflammatory responses have...
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Potential Biomarkers for Diagnosis of Overactive Bladder Patients: Urinary Nerve Growth Factor, Prostaglandin E2, and Adenosine Triphosphate

Suh YS, Ko KJ, Kim TH, Lee HS, Sung HH, Cho WJ, Lee M, Lee KS

PURPOSE: This study aimed to investigate potential biomarkers for the diagnosis of overactive bladder (OAB). METHODS: A total of 219 subjects were enrolled and divided into 2 groups: OAB subjects (n=189)...
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