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Recurrent Clostridium difficile Infection: Risk Factors, Treatment, and Prevention

Song JH, Kim YS

The most common cause of antibiotic-associated diarrhea is Clostridium difficile infection (CDI). Recurrent C. difficile infection (rCDI) often occurs after successful treatment of CDI. Due to the increased incidence and...
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Role of Acid Suppression in Acid-related Diseases: Proton Pump Inhibitor and Potassium-competitive Acid Blocker

Mori H, Suzuki H

  • KMID: 2433493
  • J Neurogastroenterol Motil.
  • 2019 Jan;25(1):6-14.
  • doi: 10.5056/jnm18139
Proton pump inhibitors are commonly utilized for the treatment of gastric acid-related diseases, such as gastroesophageal reflux disease, peptic ulcer disease, and Helicobacter pylori infection, and for the prevention of...
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Advantages and Disadvantages of Long-term Proton Pump Inhibitor Use

Kinoshita , Ishimura N, Ishihara S

  • KMID: 2413095
  • J Neurogastroenterol Motil.
  • 2018 Apr;24(2):182-196.
  • doi: 10.5056/jnm18001
Proton pump inhibitors (PPIs) potently inhibit gastric acid secretion and are widely used for treatment of acid-related diseases including gastroesophageal reflux disease and secondary prevention of aspirin/NSAID-induced ulcers. Although clinically...
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Characterization of Specific IgA Response to Antigenic Determinants of Helicobacter pylori Urease Encoded by ureA and ureB in Children

Shin MK, Jun JS, Kwon SW, Lee DH, Ha JH, Park JS, Song DH, Jung MH, Kang HL, Baik SC, Park JS, Youn HS, Cho MJ, Seo JH, Lee WK

Helicobacter pylori (H. pylori), a causative agent of chronic gastritis and gastric cancer, has several virulent factors for own survival and progression toward gastric diseases in human stomach. Of those,...
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Pharmacological Treatment for Peptic Ulcer Bleeding

Ma DW, Kim BW

Peptic ulcer bleeding (PUB) is the most common cause of non-variceal upper gastrointestinal bleeding, and its frequency has been declining over the past decades. However, mortality from PUB persists, and...
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Pathophysiology of Potassium-competitive Acid Blocker–refractory Gastroesophageal Reflux and the Potential of Potassium-competitive Acid Blocker Test

Masaoka T, Kameyama H, Yamane T, Yamamoto Y, Takeuchi H, Suzuki H, Kitagawa Y, Kanai T

  • KMID: 2422848
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):577-583.
  • doi: 10.5056/jnm18036
BACKGROUND/AIMS: Potassium-competitive acid blockers are expected to be the next generation of drugs for the treatment of diseases caused by gastric acid. In 2015, vonoprazan fumarate, a novel potassium-competitive acid...
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Is It Useful to Administer Probiotics Together With Proton Pump Inhibitors in Children With Gastroesophageal Reflux?

Belei O, Olariu L, Dobrescu A, Marcovici , Marginean

  • KMID: 2417272
  • J Neurogastroenterol Motil.
  • 2018 Jan;24(1):51-57.
  • doi: 10.5056/jnm17059
BACKGROUND/AIMS: Gastroesophageal reflux disease (GERD) is a frequent condition diagnosed in children and treated with proton pump inhibitors (PPI). Long-term PPI administration can alter intestinal bacterial population by suppressing the...
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Not All Children with Cystic Fibrosis Have Abnormal Esophageal Neutralization during Chemical Clearance of Acid Reflux

Woodley FW, Moore-Clingenpeel M, Machado RS, Nemastil C, Jadcherla , Hayes D, Kopp BT, Kaul A, Di Lorenzo C, Mousa H

PURPOSE: Acid neutralization during chemical clearance is significantly prolonged in children with cystic fibrosis, compared to symptomatic children without cystic fibrosis. The absence of available reference values impeded identification of...
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The Effect of Hâ‚‚ Receptor Antagonist in Acid Inhibition and Its Clinical Efficacy

Shim YK, Kim N

The first histamine Hâ‚‚ receptor antagonists (Hâ‚‚RAs) were developed in the early 1970s. They played a dominant role in treating peptic ulcer disease and gastroesophageal reflux disease (GERD). Hâ‚‚RAs block...
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Risk of Bacterial Infection from Proton Pump Inhibitor Use

Kim SS, Jo Y, Park SJ, Moon JS, Lee DH, Kim JJ, Lee YC, Ethics and Education Committee of Korean College of Helicobacter and Upper Gastrointestinal Research

Currently, proton pump inhibitors are used in a wide range of patients with gastroesophageal reflux disease, peptic ulcer, and upper gastrointestinal symptoms such as dyspepsia. In addition, the application of...
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Role of Potassium-Competitive Acid Blockers in Helicobacter pylori Eradication

Park JK

The first-line therapy for Helicobacter pylori infection comprises triple therapy with the combination of a proton pump inhibitor (PPI), amoxicillin, and clarithromycin. However, the H. pylori eradication rate after PPI-based...
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Treatment of dental erosion caused by intrinsic and extrinsic etiology: a case report

Lee GJ, Jin SY, Kim HJ, Min JB

Dental erosion is defined as tooth structure loss by acidic chemical substance. It is caused by extrinsic factors such as acidic foods, drugs, and working environments, and also intrinsic factors...
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Protective Effects of Cinnamic Acid Derivatives on Gastric Lesion

Lee SY, Hwang IY, Jeong CS

P-methoxycinnamic acid and 3,4,5-trimethoxycinnamic acid are the compounds found in Polygalae Radix, the root of Polygala tenuifolia Willdenow, and have been reported to have hepatoprotective and anti-neurodegenerative effects. On the...
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PMK-S005 Alleviates Age-Related Gastric Acid Secretion, Inflammation, and Oxidative Status in the Rat Stomach

Choi YJ, Kim N, Lee JY, Nam RH, Suh JH, Lee SM, Ham MH, Jo HJ, Shim YK, Park YH, Lee JC, Choi YJ, Lee HS, Lee DH

BACKGROUND/AIMS: The aim of this study was to evaluate the effect of the synthetic S-allyl-l-cysteine (SAC) PMK-S005 on gastric acid secretion, inflammation, and antioxidant enzymes in aging rats. METHODS: The rats...
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The Prevalence and Clinical Features of Non-responsive Gastroesophageal Reflux Disease to Practical Proton Pump Inhibitor Dose in Korea: A Multicenter Study

Park HJ, Park SH, Shim KN, Kim YS, Kim HJ, Han JP, Kim YS, Bang BW, Kim GH, Baik GH, Kim HH, Park SY, Kim SS

BACKGROUND/AIMS: In Korea, there are no available multicenter data concerning the prevalence of or diagnostic approaches for non-responsive gastroesophageal reflux disease (GERD) which does not respond to practical dose of...
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The Management of Systemic Voice Disorders

Woo JH

Variable systemic diseases affect larynx and vocal fold and result in voice change. Asthma and chronic obstructive pulmonary disease make increase of intra-abdomimal pressure followed by reflux of gastric acid,...
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Gastric Microbiota and Gastric Cancer

Jung K, Park MI, Kwon HJ, Kim SE

The stomach had been recognized as an organ where many bacteria cannot survive due to the presence of gastric acid. However, a number of bacteria have been detected after the...
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Factors Influencing Gastric Microbiota

Park HJ

Researches on microbiota in the stomach have entered a revolutionary period in recent years due to the advanced technology that can detect culture-independent gastric microfloras. In spite of its harsh...
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Diagnosis and treatment of functional dyspepsia

Shin CM, Huh KC

Functional dyspepsia is defined as the presence of the symptoms that originate from the gastroduodenal area, without evidence of any organic, systemic, or metabolic disease that could explain these symptoms....
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Gastroprotective Activities of Sennoside A and Sennoside B via the Up-Regulation of Prostaglandin E2 and the Inhibition of H+/K+-ATPase

Hwang IY, Jeong CS

Sennoside A (erythro) and sennoside B (threo) are dianthrone glycosides and diastereomers. We investigated their abilities to prevent the gastric lesions associated with diseases, such as, gastritis and gastric ulcer....
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