Korean J Helicobacter Up Gastrointest Res.  2016 Jun;16(2):73-81. 10.7704/kjhugr.2016.16.2.73.

Gastric Microbiota and Gastric Cancer

Affiliations
  • 1Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea. mipark@kosinmed.or.kr

Abstract

The stomach had been recognized as an organ where many bacteria cannot survive due to the presence of gastric acid. However, a number of bacteria have been detected after the discovery of Helicobacter pylori with recent advances in nucleotide sequencing techniques and bioinformatics. These include Proteobacteria, Firmicutes, Bacteroidetes, Actinobacteria and Fusobacteria. Several animal studies suggested that the imbalance of gastric microbiotas could be associated with the development of gastric cancer. Changes in the composition of the gastric microbiota may increase the production of N-nitroso compounds, which is known to be a carcinogen. Further studies on the actual function and proteomics of gastric microbiota could be beneficial for prevention, early diagnosis, and new treatment strategies of gastric cancer.

Keyword

Gastric cancer; Helicobacter pylori; Microbiota

MeSH Terms

Actinobacteria
Animals
Bacteria
Bacteroidetes
Computational Biology
Early Diagnosis
Firmicutes
Fusobacteria
Gastric Acid
Helicobacter pylori
Microbiota*
Proteobacteria
Proteomics
Stomach
Stomach Neoplasms*
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