- New Insights on the Mechanisms Affecting Fertility in Men with Non-Seminoma Testicular Cancer before Cancer Therapy
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Dias TR, Agarwal A, Pushparaj , Ahmad G, Sharma R
- KMID: 2471826
- World J Mens Health.
- 2020 Apr;38(2):198-207.
- doi: 10.5534/wjmh.180099
PURPOSE: Patients with non-seminoma testicular cancer (NSTC) cancer can be subfertile or infertile, and present reduced sperm quality, but the underlying mechanisms are unknown. The aim of this study was... -
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- Identification of Molecular Signatures in Mild Intrinsic Atopic Dermatitis by Bioinformatics Analysis
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Yin H, Wang S, Gu C
- KMID: 2471339
- Ann Dermatol.
- 2020 Apr;32(2):130-140.
- doi: 10.5021/ad.2020.32.2.130
BACKGROUND: Atopic dermatitis (AD) is recognized as a common inflammatory skin disease and frequently occurred in Asian and Black individuals. OBJECTIVE: Since the limitation of dataset associated with human severe AD,... -
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- Evaluation of Neo-Osteogenesis in Eosinophilic Chronic Rhinosinusitis Using a Nasal Polyp Murine Model
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Khalmuratova R, Lee M, Park JW, Shin HW
- KMID: 2468464
- Allergy Asthma Immunol Res.
- 2020 Mar;12(2):306-321.
- doi: 10.4168/aair.2020.12.2.306
PURPOSE: Osteitis refers to the development of new bone formation and remodeling of bone in chronic rhinosinusitis (CRS) patients; it is typically associated with eosinophilia, nasal polyps (NPs), and recalcitrant... -
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- Reverse vaccinology approach for the identification and characterization of outer membrane proteins of Shigella flexneri as potential cellular- and antibody-dependent vaccine candidates
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Leow CY, Kazi A, Hisyam Ismail CMK, Chuah C, Lim BH, Leow CH, Banga Singh KK
- KMID: 2470834
- Clin Exp Vaccine Res.
- 2020 Jan;9(1):15-25.
- doi: 10.7774/cevr.2020.9.1.15
PURPOSE: In the developing world, bacillary dysentery is one of the most common communicable diarrheal infections. There are approximately 169 million cases of shigellosis reported worldwide. The disease is transmitted... -
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- Comprehensive Molecular Characterization of Urological Malignancies: Literature Review of Landmark Studies
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Suh J, Jeong CW
- KMID: 2470397
- Korean J Urol Oncol.
- 2019 Dec;17(3):125-135.
- doi: 10.22465/kjuo.2019.17.3.125
Owing to recent advancements in next-generation sequencing and bioinformatics, genetic data of urological malignancies exponentially studied and published. Application of precision medicine strategies for cancer diagnosis, management is just around... -
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- TarGo: network based target gene selection system for human disease related mouse models
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Hyung D, Mallon AM, Kyung DS, Cho SY, Seong JK
- KMID: 2470013
- Lab Anim Res.
- 2019 Dec;35(4):165-171.
- doi: 10.1186/s42826-019-0023-z
Genetically engineered mouse models are used in high-throughput phenotyping screens to understand genotype-phenotype associations and their relevance to human diseases. However, not all mutant mouse lines with detectable phenotypes are... -
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- Role of Helix 8 in Dopamine Receptor Signaling
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Yang HS, Sun N, Zhao X, Kim HR, Park HJ, Kim KM, Chung KY
- KMID: 2462878
- Biomol Ther.
- 2019 Nov;27(6):514-521.
- doi: 10.4062/biomolther.2019.026
G protein-coupled receptors (GPCRs) are membrane receptors whose agonist-induced dynamic conformational changes trigger heterotrimeric G protein activation, followed by GRK-mediated phosphorylation and arrestin-mediated desensitization. Cytosolic regions of GPCRs have been... -
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- Proteomic Analysis on Exosomes Derived from Patients’ Sera Infected with Echinococcus granulosus
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Wang W, Zhou X, Cui F, Shi C, Wang Y, Men Y, Zhao W, Zhao J
- KMID: 2463736
- Korean J Parasitol.
- 2019 Oct;57(5):489-497.
- doi: 10.3347/kjp.2019.57.5.489
Cystic echinococcosis (CE), a zoonotic disease caused by Echinococcus granulosus at the larval stage, predominantly develops in the liver and lungs of intermediate hosts and eventually results in organ malfunction... -
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- A Computational Modeling Reveals That Strength of Inhibitory Input, E/I Balance, and Distance of Excitatory Input Modulate Thalamocortical Bursting Properties
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Park S, Sohn JW, Cho J, Huh Y
- KMID: 2463712
- Exp Neurobiol.
- 2019 Oct;28(5):568-577.
- doi: 10.5607/en.2019.28.5.568
The thalamus is a brain structure known to modulate sensory information before relaying to the cortex. The unique ability of a thalamocortical (TC) neuron to switch between the high frequency... -
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- The Long Non-Coding RNA CASC2 Suppresses Cell Viability, Migration, and Invasion in Hepatocellular Carcinoma Cells by Directly Downregulating miR-183
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Sun J, Liu L, Zou H, Yu W
- KMID: 2459143
- Yonsei Med J.
- 2019 Oct;60(10):905-913.
- doi: 10.3349/ymj.2019.60.10.905
PURPOSE: Hepatocellular carcinoma (HCC) is the most common malignant tumor of liver cells. Researchers have reported that cancer susceptibility candidate 2 (CASC2), a long non-coding RNA, is down-regulated in various... -
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- In silico approach to calculate the transcript capacity
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Lee YS, Won KH, Oh JD, Shin D
- KMID: 2462045
- Genomics Inform.
- 2019 Sep;17(3):e31.
- doi: 10.5808/GI.2019.17.3.e31
We sought the novel concept, transcript capacity (TC) and analyzed TC. Our approach to estimate TC was through an in silico method. TC refers to the capacity that a transcript... -
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- Anti-inflammatory Activity of Sambucus Plant Bioactive Compounds against TNF-α and TRAIL as Solution to Overcome Inflammation Associated Diseases: The Insight from Bioinformatics Study
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Putra WE, Ode Salma , Rifa'i M
- KMID: 2459962
- Nat Prod Sci.
- 2019 Sep;25(3):215-221.
- doi: 10.20307/nps.2019.25.3.215
Inflammation is the crucial biological process of immune system which acts as body's defense and protective response against the injuries or infection. However, the systemic inflammation devotes the adverse effects... -
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- Transcriptome Analysis Identifies an Attenuated Local Immune Response in Invasive Nonfunctioning Pituitary Adenomas
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Kim YH, Kim JH
- KMID: 2458634
- Endocrinol Metab.
- 2019 Sep;34(3):314-322.
- doi: 10.3803/EnM.2019.34.3.314
BACKGROUND: Invasive nonfunctioning pituitary adenomas (NFPAs) remain challenging due to their high complication rate and poor prognosis. We aimed to identify the distinctive molecular signatures of invasive NFPAs, compared with... -
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- Long Intergenic Non-Protein Coding RNA 665 Regulates Viability, Apoptosis, and Autophagy via the MiR-186-5p/MAP4K3 Axis in Hepatocellular Carcinoma
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Shan Y, Li P
- KMID: 2457480
- Yonsei Med J.
- 2019 Sep;60(9):842-853.
- doi: 10.3349/ymj.2019.60.9.842
PURPOSE: Long intergenic non-protein coding RNA 665 (LINC00665) plays a vital role in the development of cancer. Its function in hepatocellular carcinoma (HCC), however, remains largely unknown. MATERIALS AND METHODS: The... -
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- Pseudolaric acid B inhibits PAX2 expression through Wnt signaling and induces BAX expression, therefore promoting apoptosis in HeLa cervical cancer cells
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Guan D, Li C, Lv X, Yang Y
- KMID: 2457155
- J Gynecol Oncol.
- 2019 Sep;30(5):e77.
- doi: 10.3802/jgo.2019.30.e77
OBJECTIVES: Pseudolaric acid B (PAB) has been shown to inhibit the growth of various tumor cells, but the molecular details of its function are still unknown. This study investigated the... -
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- Targeted Downregulation of kdm4a Ameliorates Tau-engendered Defects in Drosophila melanogaster
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Park SY, Seo J, Chun YS
- KMID: 2455488
- J Korean Med Sci.
- 2019 Aug;34(33):e225.
- doi: 10.3346/jkms.2019.34.e225
BACKGROUND: Tauopathies, a class of neurodegenerative diseases that includes Alzheimer's disease (AD), are characterized by the deposition of neurofibrillary tangles composed of hyperphosphorylated tau protein in the human brain. As... -
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- Inhibition of MicroRNA-15a/16 Expression Alleviates Neuropathic Pain Development through Upregulation of G Protein-Coupled Receptor Kinase 2
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Li T, Wan Y, Sun L, Tao S, Chen P, Liu C, Wang K, Zhou C, Zhao G
- KMID: 2455097
- Biomol Ther.
- 2019 Jul;27(4):414-422.
- doi: 10.4062/biomolther.2018.073
There is accumulating evidence that microRNAs are emerging as pivotal regulators in the development and progression of neuropathic pain. MicroRNA-15a/16 (miR-15a/16) have been reported to play an important role in... -
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- Investigation of human papillomavirus prevalence in married women and molecular characterization and phylogenetic analysis of the virus
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Yayla AE, Kadioglu B, Aydin A, Aktas O
- KMID: 2451656
- Obstet Gynecol Sci.
- 2019 Jul;62(4):264-272.
- doi: 10.5468/ogs.2019.62.4.264
OBJECTIVE: Human papillomaviruses (HPVs) are among the agents responsible for infection and cancer of the skin and mucous membranes in the human body. The aim of this study was to... -
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- Long Noncoding RNA NEAT1 Aggravates Aβ-Induced Neuronal Damage by Targeting miR-107 in Alzheimer's Disease
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Ke S, Yang Z, Yang F, Wang X, Tan J, Liao B
- KMID: 2450404
- Yonsei Med J.
- 2019 Jul;60(7):640-650.
- doi: 10.3349/ymj.2019.60.7.640
PURPOSE: Alzheimer's disease (AD) is the most common neurodegenerative disease, with a rising prevalence worldwide. Long noncoding RNAs (lncRNAs) have been found to play important roles in the development and... -
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- Fungal Genomics in Dermatology
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Lee YB, Lee SY, Seo JM, Kang MJ, Yu DS
- KMID: 2462934
- Korean J Med Mycol.
- 2019 Jun;24(2):37-44.
- doi: 10.17966/JMI.2019.24.2.37
To date, hundreds of fungal genomes have been sequenced, and many more are underway. Recently developed cutting-edge techniques generate very large amounts of data, and the field of fungal genomics... -
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