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The Amniotic Fluid Proteome Differs Significantly between Donor and Recipient Fetuses in Pregnancies Complicated by Twin-to-Twin Transfusion Syndrome

Kim SM, Cho BK, Kim BJ, Lee HY, Norwitz ER, Kang MJ, Lee SM, Park CW, Jun JK, Yi EC, Park JS

BACKGROUND: Twin-to-twin transfusion syndrome (TTTS) is a serious complication of monochorionic twin pregnancies. It results from disproportionate blood supply to each fetus caused by abnormal vascular anastomosis within the placenta....
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Protein Expression of Cyclin B1, Transferrin Receptor, and Fibronectin Is Correlated with the Prognosis of Adrenal Cortical Carcinoma

Moon SJ, Kim JH, Kong SH, Shin CS

BACKGROUND: Adrenal cortical carcinoma (ACC) is a rare cancer with a variable prognosis. Several prognostic factors of ACC have been previously reported, but a proteomic analysis has not yet been...
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Novel Associations between Related Proteins and Cellular Effects of High-Density Lipoprotein

Choi S, Park YE, Cheon EJ, Kim KY, Kim M, Ann SJ, Noh HM, Lee J, Lee CJ, Lee ST, Lee C, Lee JE, Lee SH

BACKGROUND AND OBJECTIVES: Recent studies have examined the structure-function relationship of high-density lipoprotein (HDL). This study aimed to identify and rank HDL-associated proteins involved in several biological function of HDL. METHODS:...
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Advances in urinary biomarker discovery in urological research

Kim J, Kim WT, Kim WJ

A disease-specific biomarker (or biomarkers) is a characteristic reflecting a pathological condition in human body, which can be used as a diagnostic or prognostic tool for the clinical management. A...
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Proteomic Signatures in Spermatozoa Reveal the Role of Paternal Factors in Recurrent Pregnancy Loss

Mohanty G, Jena SR, Nayak J, Kar S, Samanta L

PURPOSE: To identify the paternal factors responsible for aberrant embryo development leading to loss of foetus in recurrent pregnancy loss (RPL) through proteomic analysis of ejaculated spermatozoa. MATERIALS AND METHODS: This...
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In-Depth, Proteomic Analysis of Nasal Secretions from Patients With Chronic Rhinosinusitis and Nasal Polyps

Kim YS, Han D, Kim J, Kim DW, Kim YM, Mo JH, Choi HG, Park JW, Shin HW

PURPOSE: Chronic rhinosinusitis (CRS) is a complex immunological condition, and novel experimental modalities are required to explore various clinical and pathophysiological endotypes; mere evaluation of nasal polyp (NP) status is...
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Pathogenetic factors involved in recurrent pregnancy loss from multiple aspects

Pei CZ, Kim YJ, Baek KH

Recurrent pregnancy loss (RPL) is a common complication in obstetrics, affecting about 5% of women of childbearing age. An increase in the number of abortions results in escalation in the...
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The Role of Mucus Barrier in Ulcerative Colitis Pathogenesis Using Proteomics

Lee CM

No abstract available.
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A Validation Study of a Multiple Reaction Monitoring-Based Proteomic Assay to Diagnose Breast Cancer

Kim Y, Kang UB, Kim S, Lee HB, Moon HG, Han W, Noh DY

PURPOSE: Currently, the standard screening tool for breast cancer is screening mammography. There have been many efforts to develop a blood-based diagnostic assay for breast cancer diagnosis; however, none have...
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Efficacy of Mastocheck for Screening of Early Breast Cancer: Comparison with Screening Mammography

Kim Y, Moon HG, Lee HB, Moon WK, Cho N, Chang JM, Han W, Noh DY

PURPOSE: This study was designed to verify the effectiveness of Mastocheck, a new diagnostic tool developed with proteomics techniques using plasma proteins. In addition, checked the current state of mammography...
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Identification of proteins differentially expressed by glutamate treatment in cerebral cortex of neonatal rats

Kang JB, Park DJ, Koh PO

Glutamate leads to neuronal cell damage by generating neurotoxicity during brain development. The objective of this study is to identify proteins that differently expressed by glutamate treatment in neonatal cerebral...
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Potential biomarkers and antagonists for fluoranthene-induced cellular toxicity of bone marrow derived mesenchymal stem cells

Hoque MM, Lee YE, Kim HR, Shin MG

BACKGROUND: Fluoranthene (FR) is a common environmental pollutant that exists in a complex mixture with other polycyclic aromatic hydrocarbons (PAHs). We identified biomarkers for monitoring FR exposure and investigated the...
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LGR5 and Downstream Intracellular Signaling Proteins Play Critical Roles in the Cell Proliferation of Neuroblastoma, Meningioma and Pituitary Adenoma

Hwang M, Han MH, Park HH, Choi H, Lee KY, Lee YJ, Kim JM, Cheong JH, Ryu JI, Min KW, Oh YH, Ko Y, Koh SH

Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) has been reported to play critical roles in the proliferation of various cancer cells. However, the roles of LGR5 in brain tumors and...
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Methionine Adenosyltransferase 1: A Proteomic Surrogate Marker of Early Hepatocellular Carcinoma in Cirrhotic Patients

Lee JH, Jun MJ, Shim JH, Song GW, Tak E, Oh B, Yu E, Choi SW, An J, Lee D, Kim KM, Lim YS, Lee HC, Chung YH, Lee YS

BACKGROUND/AIMS: Because there is a lack of effective biomarkers, we aimed to discover proteomic candidate markers for hepatocellular carcinoma (HCC) in cirrhotic patients at the highest-risk of HCC, and to...
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Differences between the Molecular Mechanisms Underlying Ruptured and Non-Ruptured Carotid Plaques, and the Significance of ABCA1

Heo SH, Lee EH, Park HH, Kim BJ, Youn HC, Kim YS, Kim HY, Koh SH, Chang DI

BACKGROUND AND PURPOSE: Carotid plaques are a strong risk factor for ischemic stroke, and plaque rupture poses an even higher risk. Although many studies have investigated the pathogenic mechanisms of...
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Proteomic Biomarkers for Bisphenol A–Early Exposure and Women’s Thyroid Cancer

Lee HS, Kang Y, Tae K, Bae GU, Park JY, Cho YH, Yang M

PURPOSE: For the target treatment and prevention of women's increased thyroid cancer, we focused on risks of environmental exposure to endocrine disrupting chemicals, particularly bisphenol A (BPA), and its high...
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Downregulation of HuR Inhibits the Progression of Esophageal Cancer through Interleukin-18

Xu X, Song C, Chen Z, Yu C, Wang Y, Tang Y, Luo J

PURPOSE: The purpose of this study was to investigate the effect of human antigen R (HuR) downregulation and the potential target genes of HuR on the progression of esophageal squamous...
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Comparative proteomic analysis of outer membrane protein 43 (omp43)-deficient Bartonella henselae

Kang JG, Lee HW, Ko S, Chae JS

Outer membrane proteins (OMPs) of Gram-negative bacteria constitute the first line of defense protecting cells against environmental stresses including chemical, biophysical, and biological attacks. Although the 43-kDa OMP (OMP43) is...
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Hyperglycemia exacerbates downregulation of dynamin-like protein 1 in ischemic cerebral injury

Park DJ, Kim MO, Koh PO

Ischemic stroke is one of the leading causes of adult disability and death. Hyperglycemia is associated with an increased risk of stroke and poor outcomes after brain injury. Dynamin-like protein...
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Time-dependent proteomic and genomic alterations in Toll-like receptor-4-activated human chondrocytes: increased expression of lamin A/C and annexins

Ha SH, Kim HK, Anh NT, Kim N, Ko KS, Rhee BD, Han J

Activation of Toll-like receptor-4 (TLR-4) in articular chondrocytes increases the catabolic compartment and leads to matrix degradation during the development of osteoarthritis. In this study, we determined the proteomic and...
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