Korean J Gastroenterol.  2019 May;73(5):311-312. 10.4166/kjg.2019.73.5.311.

The Role of Mucus Barrier in Ulcerative Colitis Pathogenesis Using Proteomics

• Lee CM

• KMID: 2447603
• DOI: http://doi.org/10.4166/kjg.2019.73.5.311

Abstract

No abstract available.

MeSH Terms

Colitis, Ulcerative*
Mucus*
Proteomics*
Ulcer*

Reference

1. Danese S, Fiocchi C. Ulcerative colitis. N Engl J Med. 2011; 365:1713–1725.

2. Johansson ME, Phillipson M, Petersson J, Velcich A, Holm L, Hansson GC. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci U S A. 2008; 105:15064–15069.

3. Van der Sluis M, De Koning BA, De Bruijn AC, et al. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology. 2006; 131:117–129.

4. Velcich A, Yang W, Heyer J, et al. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science. 2002; 295:1726–1729.

5. Nowarski R, Jackson R, Gagliani N, et al. Epithelial IL-18 equilibrium controls barrier function in colitis. Cell. 2015; 163:1444–1456.

6. Birchenough GM, Nyström EE, Johansson ME, Hansson GC. A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science. 2016; 352:1535–1542.

7. Lampinen M, Rönnblom A, Amin K, et al. Eosinophil granulocytes are activated during the remission phase of ulcerative colitis. Gut. 2005; 54:1714–1720.