Int Neurourol J.  2016 Nov;20(Suppl 2):S70-S75. 10.5213/inj.1612720.360.

Urine Proteomics in the Era of Mass Spectrometry

Affiliations
  • 1Material Measurement Laboratory, Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD, USA. ashley.beasley@nist.gov

Abstract

With the technological advances of mass spectrometry (MS)-based platforms, clinical proteomics is one of the most rapidly growing areas in biomedical research. Urine proteomics has become a popular subdiscipline of clinical proteomics because it is an ideal source for the discovery of noninvasive disease biomarkers. The urine proteome offers a comprehensive view of the local and systemic physiology since the proteome is primarily composed of proteins/peptides from the kidneys and plasma. The emergence of MS-based proteomic platforms as prominent bioanalytical tools in clinical applications has enhanced the identification of protein-based urinary biomarkers. This review highlights the characteristics of urine that make it an attractive biofluid for biomarker discovery and the impact of MS-based technologies on the clinical assessment of urinary protein biomarkers.

Keyword

Urine; Biomarkers; Proteomics; Mass Spectrometry

MeSH Terms

Biomarkers
Kidney
Mass Spectrometry*
Physiology
Plasma
Proteome
Proteomics*
Biomarkers
Proteome
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