Int Neurourol J.
2016 Nov;20(Suppl 2):S70-S75. 10.5213/inj.1612720.360.
Urine Proteomics in the Era of Mass Spectrometry
- Affiliations
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- 1Material Measurement Laboratory, Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD, USA. ashley.beasley@nist.gov
- KMID: 2362499
- DOI: http://doi.org/10.5213/inj.1612720.360
Abstract
- With the technological advances of mass spectrometry (MS)-based platforms, clinical proteomics is one of the most rapidly growing areas in biomedical research. Urine proteomics has become a popular subdiscipline of clinical proteomics because it is an ideal source for the discovery of noninvasive disease biomarkers. The urine proteome offers a comprehensive view of the local and systemic physiology since the proteome is primarily composed of proteins/peptides from the kidneys and plasma. The emergence of MS-based proteomic platforms as prominent bioanalytical tools in clinical applications has enhanced the identification of protein-based urinary biomarkers. This review highlights the characteristics of urine that make it an attractive biofluid for biomarker discovery and the impact of MS-based technologies on the clinical assessment of urinary protein biomarkers.
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