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The role of postoperative neutrophil-to-lymphocyte ratio as a predictor of postoperative major complications following total gastrectomy for gastric cancer

Kwak JS, Kim SG, Lee SE, Choi WJ, Yoon DS, Choi IS, Moon JI, Sung NS, Kwon SU, Bae IE, Lee SJ, Roh SJ

Purpose: This study was performed to investigate the role of the perioperative neutrophil-to-lymphocyte ratio (NLR) as an early predictor of major postoperative complications after total gastrectomy for gastric cancer. Methods: This...
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Amino Acid Levels as Potential Biomarkers of Multiple Sclerosis in Elderly Patients: Preliminary Report

Rzepiński , Kośliński P, Gackowski M, Koba M, Maciejek Z

Background and Purpose Aging in multiple sclerosis is associated with both disease- and age-dependent neurodegeneration. Serum metabolomic profiling of amino acids seems to be a promising method for searching for...
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Quantitative Susceptibility Mapping of Brain Iron Deposition in Patients With Recurrent Depression

Duan X, Xie Y, Zhu X, Chen L, Li F, Feng G, Li L

Objective Recurrence is the most significant feature of depression and the relationship between iron and recurrent depression is still lack of direct evidence in vivo. Methods Twenty-one patients with depression and...
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Preoperative lymphocyte-to-C-reactive protein ratio predicts hepatocellular carcinoma recurrence after surgery

Utsumi M, Inagaki M, Kitada K, Tokunaga N, Kondo M, Sakurai Y, Yunoki K, Hamano R, Miyasou H, Tsunemitsu Y, Otsuka S

Purpose: This study was performed to determine the prognostic value of lymphocyte-to-CRP ratio after curative resection for hepatocellular carcinoma. Methods: Between July 2010 and October 2021, 173 consecutive patients (144 male,...
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Downstream Neighbor of Son Overexpression is Associated With Breast Cancer Progression and a Poor Prognosis

Qi Y, Wu H, Liu C, Zheng D, Yan C, Hu W, Zhang X, Dai X

Purpose: The incidence rate of breast cancer (BC) has increased annually. Downstream neighbor of son (DONSON) critically affects cell cycle progression and maintains stable genomic properties; however, its relevant effects...
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Clinical Evaluation of Digital Therapeutics: Present and Future

Huh KY, Oh J, Lee S, Yu KS

Objectives: Digital therapeutics (DTx) are software-based therapeutic interventions based on clinical evidence. Randomized clinical trials (RCTs) are often the source of clinical evidence, similar to conventional drugs or medical devices....
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Genomic Profiling of Prostate Cancer: An Updated Review

Hatano K, Nonomura N

Understanding the genomic profiling of prostate cancer is crucial, owing to the emergence of precision medicine to guide therapeutic approaches. Over the last decade, integrative genomic profiling of prostate tumors...
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A crystal ball to forecast treatment responsiveness in nonalcoholic fatty liver disease

Hwang S, Kim W

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Fatty Acid-Binding Protein 4 in Patients with and without Diabetic Retinopathy

Huang P, Zhao X, Sun Y, Wang X, Ouyang R, Jiang Y, Zhang X, Hu R, Tang Z, Gu Y

Background: Fatty acid-binding protein 4 (FABP4) has been demonstrated to be a predictor of early diabetic nephropathy. However, little is known about the relationship between FABP4 and diabetic retinopathy (DR)....
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Multiple biomarkers are more accurate than a combination of carbohydrate antigen 125 and human epididymis protein 4 for ovarian cancer screening

Kang KN, Koh EY, Jang JY, Kim CW

Objective The objective of this study was to compare and evaluate the diagnostic value of serum carbohydrate antigen 125 (CA125) and/or human epididymis protein 4 (HE4) and a panel of novel...
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Evaluation of P57, P53 and Ki67 Expression in Meningiomas

Küçükosmanoğlu , Karanis M, Ünlü Y, Çöven

Objective : We conducted this study with the aim of predicting the biological behavior of meningiomas, and determining the benefits of associating histological subtype and grade with the expression of...
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Next-generation Proteomics-Based Discovery, Verification, and Validation of Urine Biomarkers for Bladder Cancer Diagnosis

Suh J, Han D, Ku JH, Kim HH, Kwak C, Jeong CW

Purpose We aimed to identify, verify, and validate a multiplex urinary biomarker-based prediction model for diagnosis and surveillance of urothelial carcinoma of bladder, using high-throughput proteomics methods. Materials and Methods Label-free quantification...
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Impact of Aging on Urinary Natriuretic Peptides in Nocturia and Nocturnal Polyuria

Khosla L, Boroda JU, Salama J, Rahman SN, Gordon DJ, Moy MW, Akivis Y, Akivis A, Lazar JM, Weiss JP, Birder LA

Purpose: The pathophysiology of nocturia and nocturnal polyuria (NP), conditions that become more prevalent with aging, may in part be explained by changes in hormones involved in water homeostasis. The...
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Genetic variations affecting response of radiotherapy

Choi EK

Radiation therapy (RT) is a very important treatment for cancer that irradiates a large amount of radiation to lead cancer cells and tissues to death. The progression of RT in...
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Commutability Assessment of Frozen Human Serum Pools for External Quality Assessment of Tumor Markers

Cho Ej, Kim SH, Hong J, Lee H, Hyun J, Cho SE, Lee W, Kim HS, Oh EJ, Chun S, Min WK

Background: Commutability is essential to harmonize different measuring systems and to evaluate the performance of participating laboratories in external quality assessment (EQA). This study aims to assess the com mutability...
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Establishment of Critical Difference for Diagnostic Immunoassays

Yu S, Moon SY, Shin KH, Lee SM, Park CM, Jun KR

Background: Critical difference (CD) is a significant difference between sequential laboratory results in a patient and is a major parameter for comparative evaluation of quantitative clinical laboratory tests, and how...
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Effects of Muscles on Bone Metabolism—with a Focus on Myokines

Kim BJ

Skeletal muscles and bones, the largest tissues in the body of a non-obese person, comprise the musculoskeletal system, which allows mobility and protects internal organs. Although muscles and bones are...
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Is the oncological impact of vascular invasion more important in right colon cancer?

Son GM

Vascular invasion is an unfavorable prognostic factor for the recurrence and systemic metastasis of colon cancer. An interesting study in this issue evaluate the difference in the oncological impact of...
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The impact of single dose intravenous dexamethasone as an adjunctive therapy for primary treatment on concentrations of inflammatory biomarkers in children with Kawasaki disease

Kwon JE

Purpose: This study was performed to investigate the impact of single dose dexamethasone as an adjunctive therapy for primary treatment on values of inflammatory markers in children with Kawasaki disease...
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Genotoxic, biochemical and histological biomarkers of subacute concentrations of paraquat and glyphosate in Nile Tilapia

Aribisala OA, Sogbanmu TO, Kemabonta KA

The use of herbicides for increased food production may pose risk to non-target organisms. This study evaluated the acute toxicity, genotoxic, biochemical, and histological biomarkers of subacute concentrations of paraquat...
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