J Korean Neurol Assoc.  2003 Dec;21(6):584-599.

Application of Proteomics and Protein Chip Analysis in the Diagnosis of Neurodegenerative Disorders

Affiliations
  • 1Division of Molecular Life Sciences and Center for Cell Signaling Research, Ewha Womans University, Seoul, Korea. cchoi@ewha.ac.kr

Abstract

As we face an increase of the adult population suffering from dementia, a typical senile disorder, it is imperative to develop appropriate tools for early detection and differential diagnosis of dementia. Recently, proteomics techniques have been proposed to be used for diagnosis of neurodegenerative disorders by identifying numerous biological markers that are known to increase or decrease in the cerebrospinal fluid or serum of dementic patients. Protein chip analysis, one of the most important techniques of proteomics, is suggested to be useful for examining various modifications of proteins as the high throughput screening method using small volumes of precious samples in a short period. We describe here a list of biological markers, such as A beta, APP, tau, ubiquitin, S100B, soluble IL-6 receptor, beta 2 micoglobulin and prostaglandin E2, proposing that these molecules can be used as biochemical markers of dementia. Therefore, we suggest that the proteomic approaches to analyze the amount and modifications of these proteins might be powerful tools for early detection and differential diagnosis of various neurodegenerative disorders as well as assessment of disease progress.

Keyword

Neurodegenerative Disorders; Proteomics; Biomarker; Protein array analysis; Cerebrospinal fluid

MeSH Terms

Adult
Biomarkers
Cerebrospinal Fluid
Dementia
Diagnosis*
Diagnosis, Differential
Dinoprostone
Humans
Mass Screening
Neurodegenerative Diseases*
Protein Array Analysis*
Proteomics*
Receptors, Interleukin-6
Ubiquitin
Biological Markers
Dinoprostone
Receptors, Interleukin-6
Ubiquitin
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