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Application of Iron Related Magnetic Resonance Imaging in the Neurological Disorders

Kim TH, Lee JH

Iron is an important element for brain oxygen transport, myelination, DNA synthesis and neurotransmission. However, excessive iron can generate reactive oxygen species and contribute neurotoxicity. Although brain iron deposition is...
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Amyloidogenic Protein of alpha-Synuclein

Yang JE, Paik SR

Amyloidogenesis is the key pathological phenomenon commonly observed in various neurodegenerative disorders. alpha-Synuclein is the major constituent of Lewy bodies as a common pathological signature of Lewy body diseases (LBDs)...
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Misfolded Proteins in Neurodegenerative Dementias: Molecular Mechanisms

Yang HD, Ho DH, Yi MJ, Seol W, Kim SY

During recent years, there has been remarkable progress with respect to the identification of molecular mechanisms and underlying pathology of neurodegenerative dementias. The latest evidence indicates that a common cause...
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Occupational Neurological Disorders in Korea

Kim EA, Kang SK

The purpose of this article was to provide a literature review of occupational neurological disorders and related research in Korea, focusing on chemical hazards. We reviewed occupational neurological disorders investigated...
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Autophagy and Neurodegenerative Diseases

Paek J, Kim B

  • KMID: 1813203
  • J Korean Neurol Assoc.
  • 2009 Aug;27(3):206-214.
Autophagy is a highly regulated cellular mechanism that results in the bulk degradation of long-lived proteins and organelles and which seems to be implicated in a variety of physiological and...
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Efficient Induction of Dopaminergic Neurons from Embryonic Stem Cells for Application to Parkinson's Disease

Kim DW

For cell replacement therapy of neurodegenerative diseases such as Parkinson's disease (PD), methods for efficiently generating midbrain dopaminergic (DA) neurons from embryonic stem (ES) cells have been investigated. Two aspects...
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Application of Proteomics and Protein Chip Analysis in the Diagnosis of Neurodegenerative Disorders

Ryu W, Choi C

  • KMID: 2185762
  • J Korean Neurol Assoc.
  • 2003 Dec;21(6):584-599.
As we face an increase of the adult population suffering from dementia, a typical senile disorder, it is imperative to develop appropriate tools for early detection and differential diagnosis of...
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The Role of the Ubiquitin-Proteasome Pathway in Neurodegenerative Disorders

Choi K, Choi C

  • KMID: 2185761
  • J Korean Neurol Assoc.
  • 2003 Dec;21(6):573-583.
Impaired function of the Ubiquitin (Ub)/proteasome pathway is one of the molecular mechanisms underlying aging process and neurodegenerative disorders such as Parkinson's Disease and Alzheimer's Disease (AD). Among many vital...
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