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Big data differential analysis of microglial cell responses in neurodegenerative diseases

Tabassum R, Jeong NY, Chung HJ

Microarray technology has become an indispensable tool for monitoring the levels of gene expression in a given organism through organization, analysis, interpretation, and utilization of biological sequences. Importantly, preliminary microarray...
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Photobiomodulation as a treatment for neurodegenerative disorders: current and future trends

Hong N

Photobiomodulation (PBM) is a rapidly growing as an innovative therapeutic modality for various types of diseases in recent years. Neuronal degeneration is irreversible process and it is proven to be...
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Extracellular Vesicles in Neurodegenerative Diseases: A Double-Edged Sword

Lee JY, Kim HS

Extracellular vesicles (EVs), a heterogenous group of membrane-bound particles, are virtually secreted by all cells and play important roles in cell-cell communication. Loaded with proteins, mRNAs, non-coding RNAs and membrane...
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Neurodegenerative Disease and Speech Rehabilitation

Yoon JH

Neurodegenerative diseases such as Parkinson's disease and amyotrophic lateral sclerosis may induce impairment of speech motor system. This review discusses the characteristics of dysarthria and symptom management for these conditions....
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A Systematic Review of the Effectiveness of Medical Cannabis for Psychiatric, Movement and Neurodegenerative Disorders

Lim K, See YM, Lee J

The discovery of endocannabinoid’s role within the central nervous system and its potential therapeutic benefits have brought forth rising interest in the use of cannabis for medical purposes. The present...
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Percutaneous Endoscopic Gastrostomy Tube Insertion in Neurodegenerative Disease: A Retrospective Study and Literature Review

Sarkar P, Cole A, Scolding N, Rice CM

BACKGROUND/AIMS: With the notable exceptions of dementia, stroke, and motor neuron disease, relatively little is known about the safety and utility of percutaneous endoscopic gastrostomy (PEG) tube insertion in patients...
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Outcomes and Safety Issues Related to Percutaneous Endoscopic Gastrostomy in Neurodegenerative Diseases

Lim YJ

No abstract available.
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MicroRNA Biomarkers in Neurodegenerative Diseases and Emerging Nano-Sensors Technology

Shah P, Cho SK, Thulstrup , Bjerrum MJ, Lee PH, Kang JH, Bhang YJ, Yang SW

MicroRNAs (miRNAs) are essential small RNA molecules (20–24 nt) that negatively regulate the expression of target genes at the post-transcriptional level. Due to their roles in a variety of biological...
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Pathophysiological Role of Neuroinflammation in Neurodegenerative Diseases and Psychiatric Disorders

Hong H, Kim BS, Im HI

  • KMID: 2309833
  • Int Neurourol J.
  • 2016 May;20(Suppl 1):S2-S7.
Brain diseases and disorders such as Alzheimer disease, Parkinson disease, depression, schizophrenia, autism, and addiction lead to reduced quality of daily life through abnormal thoughts, perceptions, emotional states, and behavior....
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The Role of Oxidative Stress in Neurodegenerative Diseases

Kim GH, Kim JE, Rhie SJ, Yoon S

Oxidative stress is induced by an imbalanced redox states, involving either excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system. The brain is one of organs...
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Stem Cell Therapy for Neurodegenerative Diseases

Yee JZ, Oh KW, Kim SH

Neurodegenerative diseases are the hereditary and sporadic conditions which are characterized by progressive neuronal degeneration. Neurodegenerative diseases are emerging as the leading cause of death, disabilities, and a socioeconomic burden...
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Voxel-Based Morphometry Study of Gray Matter Abnormalities in Neurodegenerative Disease with Obsessive-Compulsive Behaviors

Lee KJ, Miller BL

OBJECTIVES: Obsessive-compulsive(OC) symptoms have yet to be directly studied in neurodegenerative conditions involving behavioral changes. To examine regional abnormalities in the brains of dementia patients with OC symptoms, we assessed...
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Olfaction and Neurodegenerative Disease

Kim HY

Olfactory dysfunction is an early and common symptom of many neurodegenerative diseases, particularly of Parkinson's disease, Alzheimer's disease, and mild cognitive impairment that heralds progression to dementia. Olfactory impairment is...
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Sleep Disorders in Neurodegenerative Disorders

Seo JG, Park SP, Lee HW

  • KMID: 2334722
  • J Korean Sleep Res Soc.
  • 2014 Jun;11(1):1-4.
Neurodegenerative diseases result from deterioration of neurons which may eventually lead to central nervous system-related dysfunction including sleep disorders. The pathogenesis of these disturbances may be secondary to direct structural...
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A Decade of Research on TLR2 Discovering Its Pivotal Role in Glial Activation and Neuroinflammation in Neurodegenerative Diseases

Hayward JH, Lee SJ

Toll-like receptors (TLRs) belong to a class of pattern recognition receptors that play an important role in host defense against pathogens. TLRs on innate immune cells recognize a wide variety...
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Role of Oxidative Stress in Neurodegenerative Diseases and Ischemic Stroke, and Prospects of Antioxidant Therapies as a New Therapeutic Strategy

Koh SH, Kim SH

  • KMID: 2053699
  • Hanyang Med Rev.
  • 2006 Feb;26(1):33-43.
Roles of oxidative stress have recently been emphasized in the pathogenic mechanisms of neurodegenerative diseases and ischemic stroke. Many recent increasing evidence support that oxidative stress induces neuronal death related...
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Application of Proteomics and Protein Chip Analysis in the Diagnosis of Neurodegenerative Disorders

Ryu W, Choi C

  • KMID: 2185762
  • J Korean Neurol Assoc.
  • 2003 Dec;21(6):584-599.
As we face an increase of the adult population suffering from dementia, a typical senile disorder, it is imperative to develop appropriate tools for early detection and differential diagnosis of...
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The Role of the Ubiquitin-Proteasome Pathway in Neurodegenerative Disorders

Choi K, Choi C

  • KMID: 2185761
  • J Korean Neurol Assoc.
  • 2003 Dec;21(6):573-583.
Impaired function of the Ubiquitin (Ub)/proteasome pathway is one of the molecular mechanisms underlying aging process and neurodegenerative disorders such as Parkinson's Disease and Alzheimer's Disease (AD). Among many vital...
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Dopamine Transporter Imaging in Neurodegenerative Disorders

Kim JW

  • KMID: 1516897
  • Korean J Nucl Med.
  • 2003 Feb;37(1):34-42.
The dopamine transporter (DAT) is responsible for the re-uptake of dopamine from the synaptic cleft and is located on dopaminergic nerve terminals only. DAT single photon emission computed tomography (SPECT)...
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Molecular Genetics on the Hereditary Neurodegenerative Disorders caused by Trinucleotide Expansion

Jin DK

  • KMID: 1747711
  • J Korean Pediatr Soc.
  • 1996 Jul;39(7):894-900.
No abstract available.
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