Exp Neurobiol.  2012 Mar;21(1):1-8. 10.5607/en.2012.21.1.1.

Neuronal Autophagy: A Housekeeper or a Fighter in Neuronal Cell Survival?

• Lee JA

• KMID: 2165384
• DOI: http://doi.org/10.5607/en.2012.21.1.1

Abstract

Neurons have highly dynamic cellular processes for their proper functions such as cell growth, synaptic formation, or synaptic plasticity by regulating protein synthesis and degradation. Therefore, the quality control of proteins in neurons is essential for their physiology and pathology. Autophagy is a cellular degradation pathway by which cytosolic components are sequestered in autophagosomes and degraded upon their fusion with lysosomal components. Thus, the autophagic pathway may play important roles in neuronal cell survival and neuronal function under physiological condition and pathological conditions. Recent several findings suggest that the loss of basal autophagy or imbalance of autophagic flux leads to neurodegeneration. Autophagosomes accumulate abnormally in affected neurons of several neurodegenerative diseases such as Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), or Frontotemporal dementia (FTD). Thus, the understanding how autophagy is associated with several neurological diseases would be the first step for new therapeutic intervention in neurological disorders. In this review, I will discuss the molecular mechanism of autophagy in neurons and autophagy-associated neurodegenerative diseases.

Keyword

neuron; autophagy; neurodegenerative disease; homeostasis

MeSH Terms

Alzheimer Disease
Autophagy
Cell Survival
Cytosol
Frontotemporal Dementia
Homeostasis
Huntington Disease
Nervous System Diseases
Neurodegenerative Diseases
Neurons
Parkinson Disease
Plastics
Proteins
Quality Control
Resin Cements
Plastics
Proteins
Resin Cements