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NF-kappaB Activation in T Helper 17 Cell Differentiation

Park SH, Cho G, Park SG

CD28/T cell receptor ligation activates the NF-kappaB signaling cascade during CD4 T cell activation. NF-kappaB activation is required for cytokine gene expression and activated T cell survival and proliferation. Recently,...
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Effect of Triamcinolone Acetonide on the Survival and Nitric Oxide Production in Cultured Human Tenon's Capsule Fibroblasts

Lee HW, Kim JW

  • KMID: 2337232
  • J Korean Ophthalmol Soc.
  • 2005 Nov;46(11):1919-1924.
PURPOSE: To investigate the effect of triamcinolone acetonide (TA) on cell survival and nitric oxide (NO) production in cultured human Tenon's capsule fibroblast (FB) cells. METHODS: After exposed to TA,...
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Radition effect on colony formation of hela.S3(SC) cell line

Shin SO, Kim SK, Kim MS

Since discovery of X-rays, radiotherapy has evolved into one of the most scientific branches of medicine and has established its role as the primary line or the secondary line of...
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Development of semi-empirical model for radiochemical reactions

Lee RJ, Suh HS

A mathematical model, which represents the radio-chemical reactions in water, was developed to study the effect of the radio-chemical products on cell kiling. The five differential equations were solved using...
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Inductoin of Radioresistance by Overexpression of Glutathione S-Transferase K1 (hGSTK1) in MCF-7 Cells

Kim JC, Shin SO

  • KMID: 1613505
  • J Korean Soc Ther Radiol Oncol.
  • 2001 Dec;19(4):381-388.
PURPOSE: This study was conducted to assess the effects of x-irradiation on the expression of the novel glutathione S-transferase K1 gene. MATERIALS AND METHODS: Human glutathione S-transferase K1 (hGSTK1) DNA...
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Effects of Valproic Acid on the Survival of Human Tennon's Capsule Fibroblasts

Lee SE, Kim JW

PURPOSE: To investigate the effects of valproic acid on the survival of cultured human Tenon's capsule fibroblasts (HTFBs). METHODS: Primary cultured HTFBs were exposed to 0, 0.25, 0.5, and 1.0 mM...
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Effect of Trypan Blue on the Survival of Cultured Trabecular Meshwork Cells

Kang HR, Hwang SJ, Kim JW

PURPOSE: To evaluate the effects of trypan blue (TB) on the survival of cultured human trabecular meshwork cells (HTMCs). METHODS: Primarily cultured HTMCs were exposed to 0.05, 0.10 or 0.50% TB...
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Effect of Benzalkonium, Mitomycin-C and Dexamethasone on Stress in Trabecular Meshwork Cells

Kim BM, Kim JW

PURPOSE: To investigate the effects of benzalkonium chloride (BAC), mitomycin C (MMC) and dexamethasone (DEX) on cellular stress in cultured human trabecular meshwork cell (HTMC) monolayers. METHODS: HTMCs were cultured in...
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Dexamethasone effects on survival, differentiation, and proliferation of peritoneal (or B-1 cells) and splenic B cells

Choi JH, Jeung IC, Park DC

  • KMID: 2273202
  • Korean J Obstet Gynecol.
  • 2008 Jan;51(1):73-81.
OBJECTIVE: Although the characteristic feature and function of peritoneal B (B-1) cells are very different from splenic B (B-2) cells, peritoneal B cell study is not known well. The aim...
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B Cell Targeted Therapy in Rheumatic Disease

Suh CH

B cells play an important role in the pathogenesis of autoimmune disease. B cells not only produce pathogenic autoantibodies, but also present self-antigens to T cells and provide costimulatory signals...
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Effect of Berberine on Cell Survival in the Developing Rat Brain Damaged by MK-801

Lee T, Heo H, Kim Y

Berberine is an isoquinoline alkaloid isolated from goldenthread, Coptidis Rhizoma and shown to have many biological and pharmacological effects. We previously reported that berberine promotes cell survival and differentiation of...
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Effects of Hypothermia on Astrocytes Death Due to Depolarization or Inhibitors of Glycolysis and Oxidative Phosphorylation

Kim MH, Shin B

BACKGROUND: There are evidences that cytotoxic cell death occurs first by intracellular sodium entry and then followed by calcium accumulation during ischemic damage. To investigate the protective effect of hypothermia...
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Prognostic Significance of Bcl-2 Expression in Transitional Cell Carcinoma of the Bladder

Shin KY, Kong G, Moon HS, Kim SJ, Lee TY, Lee JD, Woo YN

  • KMID: 1914083
  • Korean J Urol.
  • 1996 Oct;37(10):1080-1086.
The protein encoded by the Bcl-2 proto-oncogene has been shown to prolong cell survival by preventing programmed cell death (apoptosis). Recent work has elucidated Bcl-2 expression in many solid tumors...
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The Combination Effect of Sodium Butyrate, 5-aza-2'-deoxycytidine on the Tumor Suppressive Activity in RKO Colorectal Cancer and MCF-7 Breast Cancer Cell Lines

Cho HJ, Park SC, Kim KW, Kang WK, Cho HM, Kim JS, Kim YA, An CH

PURPOSE: It is known that DNA methylation is associated with histone acetylation status in regulation of gene expression. In this study, we investigate the effect of demethylating agents and histone...
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COX-2 inhibitor induced apoptosis in oral squamous cell carcinoma cell line through AKT pathway

Seo YH, Han SJ, Lee JH

  • KMID: 2184413
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2008 Jan;30(1):30-40.
The objectives of this study was to check up the effect of celecoxib, COX-2 inhibitor, on the pathogenesis of oral squamous cell carcinoma. After mefenamic acid, aspirin and celecoxib, COX-2...
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Targeting Glutamine Metabolism for Cancer Treatment

Choi YK, Park KG

Rapidly proliferating cancer cells require energy and cellular building blocks for their growth and ability to maintain redox balance. Many studies have focused on understanding how cancer cells adapt their...
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Viability evaluation of engineered tissues

Park JC, Hwang YS, Suh H

Biohybrid artificial organs encompass all devices capable of substituting for an organ or tissue function and are fabricated from both synthetic materials and living cells. The viability of engineered tissue...
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Effect of Hypoxia on the Survival and Production of Nitric Oxide in Trabecular Meshwork Cells

Jin YH, Kim JW

  • KMID: 2125788
  • J Korean Ophthalmol Soc.
  • 2004 Dec;45(12):2127-2132.
PURPOSE: To investigate the effect of hypoxia on the survival and nitric oxide (NO) production of cultured trabecular meshwork (TM) cells. METHODS: After inducing chemical hypoxia with sodium cyanide, the...
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Development of Program for Relative Biological Effectiveness (RBE) Analysis of Particle Beam Therapy

Chung Y, Ahn SH, Choi C, Park S

Relative biological effectiveness (RBE) of particle beam needs to be evaluated at particle beam therapy centers before the clinical application of the particle beam. However, since RBE analysis is implemented...
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Phosphorylation of Glycogen Synthase Kinase-3beta(S9) Induced Neuronal Cell Survival by Sulindac in the Rat Retina

Choi SM, Choi JS, Joo CK

  • KMID: 2206621
  • J Korean Ophthalmol Soc.
  • 2003 Mar;44(3):721-726.
PURPOSE: Inactivation of glycogen synthase kinase-3beta (GSK-3beta) by S9 phosphorylation is implicated in neuronal cell survival. In this study, we examined the involvement of GSK-3betaS9) phosphorylation on retina cell survival...
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