- Interleukin-1beta Modulates Proliferation, Interleukin-6 and Interleukin Receptor Expression in PC-3 and DU-145 Prostatic Cancer Cells
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Myung SC, Ahn SY, Oh SY, Won EH, Park ES, Kim KD
- KMID: 2293512
- Korean J Urol.
- 2004 Aug;45(8):810-816.
Purpose: IL-1 is a multifunctional proinflammatory cytokine. As the proliferative effects of IL-6 and IL-6 receptor expressions on prostatic cancer cells in response to IL-1 have not been determined, the... -
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- Identification of UVB Effects on Gene Expressed by Normal Human Melanocytes
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Kim HS, Park HH, Lee MH
- KMID: 1977852
- Korean J Dermatol.
- 2003 Dec;41(12):1597-1602.
BACKGROUND: Irradiation of the skin with ultraviolet rays result in alterations of immune response as well as melanogenesis and melanocarcinogenensis. These effects are largely mediated by soluble mediators released from... -
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- The expression of IL-6Ralpha and Gp130 in fallopian tubes bearing an ectopic pregnancy
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Yousefian , Novin MG, Fathabadi , Farahani R, Kachouei E
- KMID: 2263143
- Anat Cell Biol.
- 2013 Sep;46(3):177-182.
- doi: 10.5115/acb.2013.46.3.177
Women with tubal ectopic pregnancies have high levels of circulating interleukin 6 (IL-6). IL-6 treatment in vitro significantly reduces the ciliary activity of tubal epithelium. The effects of IL-6 on... -
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- Appearance of Psoriasis after Tumor Necrosis Factor-alpha Blocker and Use of Ustekinumab or Tocilizumab for Refractory Monoarthritis
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Moon J, Kwak N, Lim J, Go DJ, Lee JH, Park JK, Lee EB, Song YW, Youn JI, Lee EY
- KMID: 2222860
- J Rheum Dis.
- 2015 Aug;22(4):263-268.
- doi: 10.4078/jrd.2015.22.4.263
Nowadays, tumor necrosis factor-alpha (TNF-alpha) blockers are used for treatment of rheumatoid arthritis, inflammatory bowel diseases, ankylosing spondylitis, psoriatic arthritis, and psoriasis. Paradoxically, there are some reports on the appearance... -
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- The relationship between interleukin-6 gene G(-634)C polymorphism and change in bone mineral density after hormone replacement therapy in postmenopausal Korean women
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Lee DY, Kim JG
- KMID: 2272682
- Korean J Obstet Gynecol.
- 2005 Sep;48(9):2148-2156.
OBJECTIVE: To investigate the relationship among the G(-634)C polymorphism in interleukin-6 (IL-6) gene, change in production of IL-6 by whole blood cells (WBCs), and bone mineral density (BMD) after hormone... -
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- Updated Pathophysiology of rheumatoid arthritis
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Song YW
- KMID: 2257378
- Korean J Med.
- 2009 Jan;76(1):1-6.
Rheumatoid arthritis is a chronic inflammatory disease that primarily affects joint synovium. Although its etiology has yet to be identified, the underlying mechanism of joint inflammation is understood as autoimmune... -
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- Activation of Stat Protein in Synovial Cell in Rheumatoid Arthritis
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Shim SC, Lee IH, Jung JH, Kim TH, Jun JB, Song KW, Bae SC, Yoo DH, Kim SY
- KMID: 2202485
- J Korean Rheum Assoc.
- 2000 Mar;7(1):43-52.
OBJECTIVE: To characterize Stat activity in synovial tissue in rheumatoid arthritis (RA) in order to see if Stat molecule contributes to the pathogenesis of RA by regulatory expression of... -
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- Generation and Characterization of 1H8 monoclonal antibody against human bone marrow stromal cells
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Kang HS, Choi IP
- KMID: 2150552
- Immune Netw.
- 2001 Apr;1(1):14-25.
- doi: 10.4110/in.2001.1.1.14
BACKGROUND: Bone marrow stromal cells (BMSCs) express many cell surface molecules, which regulate the proliferation and differentiation of immune cells within the bone marrow. METHODS: To identify cell surface molecules, which... -
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- Interleukin-6 Receptor Polymorphisms Contribute to the Neurological Status of Korean Patients with Ischemic Stroke
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Kim DH, Yoo SD, Chon J, Yun DH, Kim HS, Park HJ, Kim SK, Chung JH, Kang JK, Lee SA
- KMID: 2363505
- J Korean Med Sci.
- 2016 Mar;31(3):430-434.
- doi: 10.3346/jkms.2016.31.3.430
To investigate the contribution of the interleukin-6 receptor (IL-6R) gene single nucleotide polymorphisms (SNPs) to the neurological status of Korean patients with ischemic stroke (IS), two SNPs of the IL-6R... -
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- Stromal Cell-Derived Factor-1 Promotes Myeloma Cell Growth in Both Autocrine and Paracrine Manners
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Kim SW, Kim HY, Lee HJ, Yun HJ, Kim S, Jo DY
- KMID: 2252178
- Korean J Hematol.
- 2008 Sep;43(3):127-137.
- doi: 10.5045/kjh.2008.43.3.127
BACKGROUND: The question as to whether stromal cell-derived factor-1 (SDF-1) stimulated myeloma cell growth has been controversial. We explored the possibility that SDF-1 may function as an autocrine growth factor... -
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- Tocilizumab-induced Thrombocytopenia in Patients with Rheumatoid Arthritis
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Lee JS, Oh JS, Hong S, Lee CK, Yoo B, Kim YG
- KMID: 2451510
- J Rheum Dis.
- 2019 Jul;26(3):186-190.
- doi: 10.4078/jrd.2019.26.3.186
OBJECTIVE: Interlukin-6 (IL-6) increases platelet count during inflammation and may act in a manner similar to thrombopoietin. Tocilizumab is a monoclonal antibody of the IL-6 receptor and widely used in... -
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- Application of Proteomics and Protein Chip Analysis in the Diagnosis of Neurodegenerative Disorders
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Ryu W, Choi C
- KMID: 2185762
- J Korean Neurol Assoc.
- 2003 Dec;21(6):584-599.
As we face an increase of the adult population suffering from dementia, a typical senile disorder, it is imperative to develop appropriate tools for early detection and differential diagnosis of... -
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- Anticancer Activity of Tubulosine through Suppression of Interleukin-6-Induced Janus Kinase 2/Signal Transducer and Activation of Transcription 3 Signaling
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Kim BH, Yi EH, Li YC, Park IC, Park JY, Ye SK
- KMID: 2458858
- J Breast Cancer.
- 2019 Sep;22(3):362-374.
- doi: 10.4048/jbc.2019.22.e34
PURPOSE: The chemical structure of tubulosine has been known since the mid-1960s. However, little is known about its biological and pharmacological functions. The aim of this study was to investigate... -
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- The Relationship between Serum Creatinine Concentrations and Oxidative Stress or Plasma Levels of Inflammatory Cytokine after Living Donor Renal Transplantation
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Kim JH, Park J, Kim MS, Ha H, Kim YS
- KMID: 2096256
- J Korean Surg Soc.
- 2005 May;68(5):414-421.
PURPOSE: Increased oxidative stress and chronic inflammatory process have been substantially linked with the development and progression of chronic renal failure. However, the roles of oxidative stress and inflammation in... -
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- A Case of Multicentric Castleman's Disease Having Lung Lesion Successfully Treated with Humanized Anti-interleukin-6 Receptor Antibody, Tocilizumab
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Higuchi T, Nakanishi , Takada K, Matsumoto , Okada M, Horikoshi , Suzuki K
- KMID: 1785918
- J Korean Med Sci.
- 2010 Sep;25(9):1364-1367.
- doi: 10.3346/jkms.2010.25.9.1364
This report presents the case of a patient demonstrating multicentric Castleman's disease (MCD) with a lung lesion that was successfully treated with an anti-interleukin-6 receptor antibody, tocilizumab in combination with... -
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- Cytokine Production by Whole Blood Cells: Relationship to Interleukin Gene Polymorphism and Bone Mass
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Kim JG, Ku SY, Lim KS, Jee BC, Suh CS, Kim SH, Choi YM, Moon SY
- KMID: 2157755
- J Korean Med Sci.
- 2005 Dec;20(6):1017-1022.
- doi: 10.3346/jkms.2005.20.6.1017
The aims of this study were to investigate the relationships between the production of interleukin-1 (IL-1), and IL-6 system by whole blood cells, and bone mineral density (BMD), and polymorphisms... -
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- Safety of Tocilizumab in Rheumatoid Arthritis Patients with Resolved Hepatitis B Virus Infection: Data from Real-World Experience
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Ahn SS, Jung SM, Song JJ, Park YB, Park JY, Lee SW
- KMID: 2407870
- Yonsei Med J.
- 2018 May;59(3):452-456.
- doi: 10.3349/ymj.2018.59.3.452
To investigate whether the use of IL-6 receptor antagonist (tocilizumab) might be associated with hepatitis B virus (HBV) reactivation in rheumatoid arthritis (RA) patients, particularly in those with resolved HBV... -
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- Effect of 5-FU and MTX on the Expression of Drug-resistance Related Cancer Stem Cell Markers in Non-small Cell Lung Cancer Cells
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Yi H, Cho HJ, Cho SM, Jo K, Park JA, Lee SH, Chang BJ, Kim JS, Shin HC
- KMID: 2285434
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):11-16.
- doi: 10.4196/kjpp.2012.16.1.11
Cancer stem cells (CSCs) are often characterized by the elevated expression of drug-resistance related stem-cell surface markers, such as CD133 and ABCG2. Recently, we reported that CSCs have a high... -
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