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Anticancer Activity of Tubulosine through Suppression of Interleukin-6-Induced Janus Kinase 2/Signal Transducer and Activation of Transcription 3 Signaling

Kim BH, Yi EH, Li YC, Park IC, Park JY, Ye SK

PURPOSE: The chemical structure of tubulosine has been known since the mid-1960s. However, little is known about its biological and pharmacological functions. The aim of this study was to investigate...
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Tocilizumab-induced Thrombocytopenia in Patients with Rheumatoid Arthritis

Lee JS, Oh JS, Hong S, Lee CK, Yoo B, Kim YG

OBJECTIVE: Interlukin-6 (IL-6) increases platelet count during inflammation and may act in a manner similar to thrombopoietin. Tocilizumab is a monoclonal antibody of the IL-6 receptor and widely used in...
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Safety of Tocilizumab in Rheumatoid Arthritis Patients with Resolved Hepatitis B Virus Infection: Data from Real-World Experience

Ahn SS, Jung SM, Song JJ, Park YB, Park JY, Lee SW

To investigate whether the use of IL-6 receptor antagonist (tocilizumab) might be associated with hepatitis B virus (HBV) reactivation in rheumatoid arthritis (RA) patients, particularly in those with resolved HBV...
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Interleukin-6 Receptor Polymorphisms Contribute to the Neurological Status of Korean Patients with Ischemic Stroke

Kim DH, Yoo SD, Chon J, Yun DH, Kim HS, Park HJ, Kim SK, Chung JH, Kang JK, Lee SA

To investigate the contribution of the interleukin-6 receptor (IL-6R) gene single nucleotide polymorphisms (SNPs) to the neurological status of Korean patients with ischemic stroke (IS), two SNPs of the IL-6R...
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Appearance of Psoriasis after Tumor Necrosis Factor-alpha Blocker and Use of Ustekinumab or Tocilizumab for Refractory Monoarthritis

Moon J, Kwak N, Lim J, Go DJ, Lee JH, Park JK, Lee EB, Song YW, Youn JI, Lee EY

Nowadays, tumor necrosis factor-alpha (TNF-alpha) blockers are used for treatment of rheumatoid arthritis, inflammatory bowel diseases, ankylosing spondylitis, psoriatic arthritis, and psoriasis. Paradoxically, there are some reports on the appearance...
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The expression of IL-6Ralpha and Gp130 in fallopian tubes bearing an ectopic pregnancy

Yousefian , Novin MG, Fathabadi , Farahani R, Kachouei E

Women with tubal ectopic pregnancies have high levels of circulating interleukin 6 (IL-6). IL-6 treatment in vitro significantly reduces the ciliary activity of tubal epithelium. The effects of IL-6 on...
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Effect of 5-FU and MTX on the Expression of Drug-resistance Related Cancer Stem Cell Markers in Non-small Cell Lung Cancer Cells

Yi H, Cho HJ, Cho SM, Jo K, Park JA, Lee SH, Chang BJ, Kim JS, Shin HC

Cancer stem cells (CSCs) are often characterized by the elevated expression of drug-resistance related stem-cell surface markers, such as CD133 and ABCG2. Recently, we reported that CSCs have a high...
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A Case of Multicentric Castleman's Disease Having Lung Lesion Successfully Treated with Humanized Anti-interleukin-6 Receptor Antibody, Tocilizumab

Higuchi T, Nakanishi , Takada K, Matsumoto , Okada M, Horikoshi , Suzuki K

This report presents the case of a patient demonstrating multicentric Castleman's disease (MCD) with a lung lesion that was successfully treated with an anti-interleukin-6 receptor antibody, tocilizumab in combination with...
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Updated Pathophysiology of rheumatoid arthritis

Song YW

  • KMID: 2257378
  • Korean J Med.
  • 2009 Jan;76(1):1-6.
Rheumatoid arthritis is a chronic inflammatory disease that primarily affects joint synovium. Although its etiology has yet to be identified, the underlying mechanism of joint inflammation is understood as autoimmune...
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Stromal Cell-Derived Factor-1 Promotes Myeloma Cell Growth in Both Autocrine and Paracrine Manners

Kim SW, Kim HY, Lee HJ, Yun HJ, Kim S, Jo DY

BACKGROUND: The question as to whether stromal cell-derived factor-1 (SDF-1) stimulated myeloma cell growth has been controversial. We explored the possibility that SDF-1 may function as an autocrine growth factor...
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The relationship between interleukin-6 gene G(-634)C polymorphism and change in bone mineral density after hormone replacement therapy in postmenopausal Korean women

Lee DY, Kim JG

  • KMID: 2272682
  • Korean J Obstet Gynecol.
  • 2005 Sep;48(9):2148-2156.
OBJECTIVE: To investigate the relationship among the G(-634)C polymorphism in interleukin-6 (IL-6) gene, change in production of IL-6 by whole blood cells (WBCs), and bone mineral density (BMD) after hormone...
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The Relationship between Serum Creatinine Concentrations and Oxidative Stress or Plasma Levels of Inflammatory Cytokine after Living Donor Renal Transplantation

Kim JH, Park J, Kim MS, Ha H, Kim YS

  • KMID: 2096256
  • J Korean Surg Soc.
  • 2005 May;68(5):414-421.
PURPOSE: Increased oxidative stress and chronic inflammatory process have been substantially linked with the development and progression of chronic renal failure. However, the roles of oxidative stress and inflammation in...
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Cytokine Production by Whole Blood Cells: Relationship to Interleukin Gene Polymorphism and Bone Mass

Kim JG, Ku SY, Lim KS, Jee BC, Suh CS, Kim SH, Choi YM, Moon SY

The aims of this study were to investigate the relationships between the production of interleukin-1 (IL-1), and IL-6 system by whole blood cells, and bone mineral density (BMD), and polymorphisms...
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Interleukin-1beta Modulates Proliferation, Interleukin-6 and Interleukin Receptor Expression in PC-3 and DU-145 Prostatic Cancer Cells

Myung SC, Ahn SY, Oh SY, Won EH, Park ES, Kim KD

  • KMID: 2293512
  • Korean J Urol.
  • 2004 Aug;45(8):810-816.
Purpose: IL-1 is a multifunctional proinflammatory cytokine. As the proliferative effects of IL-6 and IL-6 receptor expressions on prostatic cancer cells in response to IL-1 have not been determined, the...
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Application of Proteomics and Protein Chip Analysis in the Diagnosis of Neurodegenerative Disorders

Ryu W, Choi C

  • KMID: 2185762
  • J Korean Neurol Assoc.
  • 2003 Dec;21(6):584-599.
As we face an increase of the adult population suffering from dementia, a typical senile disorder, it is imperative to develop appropriate tools for early detection and differential diagnosis of...
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Identification of UVB Effects on Gene Expressed by Normal Human Melanocytes

Kim HS, Park HH, Lee MH

  • KMID: 1977852
  • Korean J Dermatol.
  • 2003 Dec;41(12):1597-1602.
BACKGROUND: Irradiation of the skin with ultraviolet rays result in alterations of immune response as well as melanogenesis and melanocarcinogenensis. These effects are largely mediated by soluble mediators released from...
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Generation and Characterization of 1H8 monoclonal antibody against human bone marrow stromal cells

Kang HS, Choi IP

BACKGROUND: Bone marrow stromal cells (BMSCs) express many cell surface molecules, which regulate the proliferation and differentiation of immune cells within the bone marrow. METHODS: To identify cell surface molecules, which...
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Activation of Stat Protein in Synovial Cell in Rheumatoid Arthritis

Shim SC, Lee IH, Jung JH, Kim TH, Jun JB, Song KW, Bae SC, Yoo DH, Kim SY

  • KMID: 2202485
  • J Korean Rheum Assoc.
  • 2000 Mar;7(1):43-52.
OBJECTIVE: To characterize Stat activity in synovial tissue in rheumatoid arthritis (RA) in order to see if Stat molecule contributes to the pathogenesis of RA by regulatory expression of...
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