J Dig Cancer Res.  2024 Apr;12(1):6-14. 10.52927/jdcr.2024.12.1.6.

Gastric Cancer and Non-Helicobacter pylori Microbiota

• Kim YJ

• KMID: 2555632
• DOI: http://doi.org/10.52927/jdcr.2024.12.1.6

Abstract

Gastric cancer is the 4th leading cause of death worldwide. The primary cause of gastric cancer is known to be Helicobacter pylori (H. pylori). The advancement of molecular biology has enabled the identification of microbiomes that could not be confirmed through cultivation, and it has been revealed that the microbial communities vary among normal mucosa, atrophic gastritis, intestinal metaplasia, and gastric cancer. It has also been confirmed that the composition of the microbial community differs depending on the presence or absence of H. pylori. Whether changes in the microbiome are causative factors in the carcinogenesis process is not yet clear. Experiments using animal models and in vitro studies on the role of microbes other than H. pylori in the carcinogenic process are underway, but the data is still insufficient.

Keyword

Stomach neoplasms; Microbiota; Helicobacter pylori