Nat Prod Sci.  2017 Dec;23(4):299-305. 10.20307/nps.2017.23.4.299.

Protective Effects of Cinnamic Acid Derivatives on Gastric Lesion

• Lee SY
• Hwang IY
• Jeong CS

• KMID: 2401584
• DOI: http://doi.org/10.20307/nps.2017.23.4.299

Abstract

P-methoxycinnamic acid and 3,4,5-trimethoxycinnamic acid are the compounds found in Polygalae Radix, the root of Polygala tenuifolia Willdenow, and have been reported to have hepatoprotective and anti-neurodegenerative effects. On the other hand, there are no reports of their effects on gastric lesions. This study examined the inhibitory effects of cinnamic acids, including p-methoxycinnamic acid, 3,4,5-trimethoxycinnamic acid, and 8 compounds (cinnamic acid, 2-(trifluoromethyl) cinnamic acid, 3-(trifluoromethyl) cinnamic acid, trans-4-(trifluoromethyl) cinnamic acid, 4-(dimethylamino) cinnamic acid, 3,4-(methylenedioxy) cinnamic acid and 3,4-dihydroxycinnamic acid), which were selected based on their presence in medicinal herbs and molecular weight, against gastric lesions. Animal models were used to confirm the protective effects on acute gastritis caused by the administration of HCl/EtOH. Gastric acid inhibition was examined by an acid-neutralizing test and the proton pump (H⁺/K⁺-ATPase) inhibiting activity. In addition, antioxidant tests were performed and the gastric emptying rate was determined. The results showed that cinnamic acid, p-methoxycinnamic acid, and 3,4,5-trimethoxycinnamic acid had an inhibitory effect on gastric lesions.

Keyword

Cinnamic acid; Gastritis; Gastric acid; H⁺/K⁺-ATPase

MeSH Terms

Gastric Acid
Gastric Emptying
Gastritis
Hand
Models, Animal
Molecular Weight
Plants, Medicinal
Polygala
Proton Pumps
Proton Pumps

Figure

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  Fig. 1 Effect of cinnamic acid derivatives on HCl/EtOH-induced gastritis in rats.

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  Fig. 2 Acid-neutralizing capacity of cinnamic acid derivatives.

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  Fig. 3 H+/K+-ATPase inhibiting activity of cinnamic acid derivatives in rat stomach.

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  Fig. 4 Reducing power of cinnamic acid group derivatives.

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  Fig. 5 Gastric emptying of cinnamic acid derivatives in mice.

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