Intest Res.  2015 Apr;13(2):105-111. 10.5217/ir.2015.13.2.105.

Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease

• Kim YJ
• Chang SY
• Ko HJ

• KMID: 2284876
• DOI: http://doi.org/10.5217/ir.2015.13.2.105

Abstract

Immature myeloid cells, also known as myeloid-derived suppressor cells (MDSCs), include neutrophilic and monocytic myeloid cells, and are found in inflammatory loci and secondary lymphoid organs in mice with intestinal inflammation, inflammatory bowel disease (IBD) patients, and tumor tissues. However, the roles of MDSCs in IBD are not yet well understood, and there are controversies regarding their immunosuppressive functions in IBD. In addition, recent studies have suggested that endoplasmic reticulum (ER) stress in intestinal epithelial cells, especially in Paneth cells, is closely associated with the induction of IBD. However, the ER stress in MDSCs accumulated in the inflamed tissues of IBD patients is not yet fully understood. In the current review, we discuss the presence of accumulated MDSCs in the intestines of IBD patients, and further speculate on their physiological roles in the inflammatory condition with interleukin 17-producing cells, including Th17 cells. In particular, we will discuss the divergent functions of MDSCs in ER stressed intestinal environments, including their pro-inflammatory or immunosuppressive roles, based on the consideration of unfolded protein responses initiated in intestinal epithelial cells by ER stress.

Keyword

Inflammatory bowel diseases; Myeloid-derived suppressor cell; Endoplasmic reticulum stress; Intestines; Interleukin-17

MeSH Terms

Animals
Endoplasmic Reticulum
Endoplasmic Reticulum Stress
Epithelial Cells
Humans
Inflammation
Inflammatory Bowel Diseases*
Interleukin-17
Interleukins
Intestines
Mice
Myeloid Cells
Neutrophils
Paneth Cells
Th17 Cells
Unfolded Protein Response
Interleukin-17
Interleukins

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