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Attenuation of Experimental Autoimmune Uveitis in Lewis Rats by Betaine

Choi Y, Jung K, Kim HJ, Chun J, Ahn M, Jee Y, Ko HJ, Moon C, Matsuda H, Tanaka A, Kim J, Shin T

  • KMID: 2519892
  • Exp Neurobiol.
  • 2021 Aug;30(4):308-317.
  • doi: 10.5607/en21011
Experimental autoimmune uveitis (EAU) is an animal model of human autoimmune uveitis that is characterized by the infiltration of autoimmune T cells with concurrent increases in pro-inflammatory cytokines and reactive...
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A Novel Anti-PD-L1 Antibody Exhibits Antitumor Effects on Multiple Myeloma in Murine Models via Antibody-Dependent Cellular Cytotoxicity

Ahn JH, Lee BH, Kim SE, Kwon BE, Jeong H, Choi JR, Kim MJ, Park Y, Kim BS, Kim DH, Ko HJ

Multiple myeloma is a malignant cancer of plasma cells. Despite recent progress with immunomodulatory drugs and proteasome inhibitors, it remains an incurable disease that requires other strategies to overcome its...
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The Effect of the Vitamin Protocol for Treating Sepsis or Septic Shock in Pediatric Intensive Care Unit

Ko HJ, Jung MJ, Kim JS, Son ES, Yu YM

Background: Recently, a study comprising adult patients with sepsis admitted in the intensive care unit (ICU) was conducted. The patients were treated with high doses of intravenous ascorbic acid, thiamine,...
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Morin Hydrate Inhibits Influenza Virus entry into Host Cells and Has Anti-inflammatory Effect in Influenzainfected Mice

Hong EH, Song aH, Kim SR, Cho J, Jeong B, Yang H, Jeong JH, Ahn JH, Jeong H, Kim SE, Chang SY, Ko HJ

Influenza virus is the major cause of seasonal and pandemic flu. Currently, oseltamivir, a potent and selective inhibitor of neuraminidase of influenza A and B viruses, is the drug of...
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Association between Bone Mineral Density and Serum Iron Indices in Premenopausal Women in South Korea

Kim SM, Kim AS, Ko HJ, Moon H, Choi HI, Song J

Background: Osteoporosis is characterized by a decrease in bone mineral density (BMD) and increased risk of fragility fractures. Serum iron level may interact with bone health status. This study investigated...
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Effect of Prognosis Awareness on the Survival and Quality of Life of Terminally Ill Cancer Patients: A Prospective Cohort Study

Lee H, Ko HJ, Kim AS, Kim SM, Moon H, Choi HI

Background: Physicians and caregivers are conflicted over whether to inform patients that their disease is terminal. Studies examining the effect of awareness of prognosis on the survival and quality of...
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Usefulness of preoperative magnetic resonance spectroscopy in improving the safety of a living liver donor

Shim JR, Ko HJ, Lee TB, Choi BH, Yang K, Ryu JH

Background: The steatosis of graft liver is an important factor in liver transplantation that determines the graft function in the recipient and the recovery of the remnant liver in the...
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Living donor liver transplantation at the Pusan National University Yangsan Hospital, Korea: result of living donor hepatectomy in a single center

Ko HJ, Ryu JH, Yang K, Choi BH, Lee TB, Sim JR

Background: Living donor liver transplantation is currently the most feasible treatment method for patients with end-stage liver disease. We discuss the results of living donor hepatectomy in our single center...
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Evaluation of iNSiGHT VET DXA (Dual-Energy X-ray Absorptiometry) for assessing body composition in obese rats fed with high fat diet: a follow-up study of diet induced obesity model for 8 weeks

Yeu J, Ko HJ, Kim D, Ahn Y, Kim J, Lee W, Jung I, Suh J, Lee SJ

We examined the precision, accuracy, and capability of detecting changes of Dual-Energy X-ray Absorptiometry (DXA) for the measurements of total-body weight (TBW), total-body fat weight (TBFW), and total-body lean weight...
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Modulatory action of enrofloxacin in lipopolysaccharide-induced hyper-activated mouse spleen cells

Ko HJ, Joo HG

Enrofloxacin, a fluoroquinolone, is a broad-spectrum antibiotic widely used in veterinary medicine that inhibits the action of bacterial DNA gyrase, resulting in anti-bacterial effects. This study was performed to examine...
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Understanding medical students' empathy based on Enneagram personality types

Roh HR, Park KH, Ko HJ, Kim DK, Son HB, Shin DH, Lee SH, Jung HY, Heo D

PURPOSE: High self-awareness can promote communication and empathy. The Enneagram is a well-known personality tool to enhance self-awareness. We evaluated differences in empathy among medical students using the Enneagram typology. METHODS:...
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The Relationship Between Serum 25-Hydroxyvitamin D Levels and Physical Performance in Community-Dwelling Older Adults

Moon H, Ko HJ, Kim AS

BACKGROUND: Vitamin D deficiency is a risk factor for musculoskeletal health in older adults. While many studies have explored the relationship between vitamin D deficiency and fractures, few have examined...
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Murine γδ T Cells Render B Cells Refractory to Commitment of IgA Isotype Switching

Han HJ, Jang YS, Seo GY, Park SG, Kang SG, Yoon SI, Ko HJ, Lee GS, Kim PH

γδ T cells are abundant in the gut mucosa and play an important role in adaptive immunity as well as innate immunity. Although γδ T cells are supposed to be...
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Development of New Preventive and Therapeutic Vaccines for Tuberculosis

Kwon BE, Ahn JH, Min S, Kim H, Seo J, Yeo SG, Ko HJ

Tuberculosis (TB) is a contagious disease that has been responsible for the death of one billion people in the last 200 years. Until now, the only vaccine approved for the...
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Quantitative Analysis of Oral Pathogenic Bacteria according to Smoking Using Real-Time PCR

Jeon ES, Heo HJ, Ko HJ

This study investigates the relationship between smoking and periodontal disease through quantitative analysis of intra-buccal oral pathogenic bacteria detected in smokers and aims to yield objective baseline data for applications...
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Anti-Human Rhinovirus 1B Activity of Dexamethasone viaGCR-Dependent Autophagy Activation

Lee JS, Kim SR, Song JH, Lee YP, Ko HJ

OBJECTIVES: Human rhinoviruses (HRVs) are the major cause of the common cold. Currently there is no registered, clinically effective, antiviral chemotherapeutic agent to treat diseases caused by HRVs. In this...
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Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection

Song JH, Shim A, Kim YJ, Ahn JH, Kwon BE, Pham TT, Lee J, Chang SY, Ko HJ

Human rhinoviruses (HRV) are one of the major causes of common cold in humans and are also associated with acute asthma and bronchial illness. Heat-shock protein 90 (Hsp90), a molecular...
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Therapeutic Potential of the Rhizomes of Anemarrhena asphodeloides and Timosaponin A-III in an Animal Model of Lipopolysaccharide-Induced Lung Inflammation

Park BK, So KS, Ko HJ, Kim HJ, Kwon KS, Kwon YS, Son KH, Kwon SY, Kim HP

Investigations into the development of new therapeutic agents for lung inflammatory disorders have led to the discovery of plant-based alternatives. The rhizomes of Anemarrhena asphodeloides have a long history of...
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Associations between Body Mass Index and Chronic Atrophic Gastritis and Intestinal Metaplasia

Kim N, Youn CH, Kim AS, Ko HJ, Kim HM, Moon H, Park S

BACKGROUND/AIMS: Chronic atrophic gastritis (AG) and intestinal metaplasia (IM) of the stomach are premalignant lesions. The present study aimed to examine the associations between obesity and these lesions. METHODS: A total...
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The Relationship between the Blood Level of Persistent Organic Pollutants and Common Gastrointestinal Symptoms

Kim HM, Youn CH, Ko HJ, Lee SH, Lee YM

BACKGROUND: Persistent organic pollutants (POPs) are toxic materials that cannot be broken down naturally and that easily accumulate in the body. Although several studies have attempted to uncover the effects...
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