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Effects of Interleukin-17A on the Early Stages of Arterial Thrombosis in Mice

Park Y, Shim Y, Kwon I, Lee HW, Nam HS, Choi HJ, Heo JH

Purpose: Interleukin (IL)-17A has been suggested to play a role in the growth and organization of thrombi. We examined whether IL-17A plays a role in the early stages of thrombosis...
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Effects of interleukin-17 inhibitors on hepatic fibrosis index in patients with psoriasis and metabolic dysfunction-associated fatty liver disease: Directed acyclic graphs

Takamura S, Teraki Y, Katayama E, Kawaguchi T, Kawaguchi M, Nakano D, Tsutsumi T, Nagoshi S, Nakama T, Torimura T

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A Case of Nummular Eczema-Like Eruption after Secukinumab Treatment

Eun DH, Kim D, Lee J, Yoon TY, Lee JY

  • KMID: 2526788
  • Korean J Dermatol.
  • 2022 Feb;60(2):135-138.
Secukinumab is an anti-interleukin 17A monoclonal antibody used for treating chronic plaque psoriasis. Eczematous eruption is a relatively unknown adverse effect of secukinumab. A 32-year-old man developed eczematous eruptions on...
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IL-17 and IL-17C Signaling Protects the Intestinal Epithelium against Diisopropyl Fluorophosphate Exposure in an Acute Model of Gulf War Veterans' Illnesses

Patterson KM, Vajdic TG, Martinez GJ, Feller AG, Reynolds JM

Gulf War Veterans' Illnesses (GWI) encompasses a broad range of unexplained symptomology specific to Veterans of the Persian Gulf War. Gastrointestinal (GI) distress is prominent in veterans with GWI and...
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Immunological mechanism of postherpetic neuralgia and effect of pregabalin treatment on the mechanism: a prospective single-arm observational study

Mercan A, Uzun ST, Keles S, Hacibeyoglu G, Yilmaz R, Reisli R

Background: Although neuropathic pain is a severe and common pain, its pathophysiology has not been elucidated yet. Studies in recent years have focused on the immune system’s role in the...
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The effect of lipopolysaccharide from uropathogenic Escherichia coli on the immune system, testis tissue, and spermatozoa of BALB/c mice

Khanmohammad KR, Khalili MB, Sadeh M, Talebi AR, Astani A, Shams A, Zare F

Objective: Uropathogenic Escherichia coli is known to cause urinary tract infections, and the endotoxin (lipopolysaccharide [LPS]) of this bacterium may cause deficiencies of sperm quality and morphology. In the present...
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Characteristic Clinical Features of Korean Atopic Dermatitis Patients with Interleukin-17 Receptor A Gene Mutation

Lee JW, Yu K, Lee H, Choi EH

  • KMID: 2516142
  • Korean J Dermatol.
  • 2021 May;59(4):290-295.
Background: Th17 cytokines such as interleukin-17 and interleukin-22 are expressed in atopic dermatitis lesions. Previous studies have reported increased levels of interleukin-17A, -17E, and -17F in patients with atopic dermatitis.As...
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I-Kappa-B-Zeta Regulates Interleukin-17A/ Tumor Necrosis Factor-Alpha Mediated Synergistic Induction of Interleukin-19 and Interleukin-20 in Humane Keratinocytes

Bertelsen T, Iversen L, Johansen C

Background: Interleukin (IL)-19 and IL-20 are important members of the IL-10 cytokine family, which are known to play a role in inflammatory processes. Both anti-IL-19 and -IL-20 targeting drugs have...
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Tocotrienol regulates osteoclastogenesis in rheumatoid arthritis

Kim KW, Kim BM, Won JY, Min HK, Lee SJ, Lee SH, Kim HR

Background/Aims: The present study aimed to investigate whether tocotrienol regulates interleukin 17 (IL-17)-induced osteoclastogenesis in rheumatoid arthritis (RA). Methods: We evaluated the effect of tocotrienol on IL-17-induced receptor activator of nuclear...
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Biologic therapies for the treatment of psoriatic arthritis

Kim TJ

Psoriatic arthritis (PsA) is a chronic inflammatory rheumatic disease commonly associated with plaque psoriasis that, manifests with peripheral arthritis, dactylitis, enthesitis, and axial involvement. PsA can be progressive and harmful,...
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Biologic therapies for the treatment of ankylosing spondylitis

Ahn SM, Kim YG

Ankylosing spondylitis (AS) is a chronic inflammatory disease predominantly affecting the axial skeleton. AS treatment aims to reduce pain and inflammation and maintain functional capacity. Nonsteroidal anti-inflammatory drugs are the...
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Cervicovaginal fluid cytokines as predictive markers of preterm birth in symptomatic women

Park S, You YA, Yun H, Choi SJ, Hwang HS, Choi SK, Lee SM, Kim YJ

Objective Here, we investigated whether cytokines in the cervicovaginal fluid (CVF) can be predictive markers of preterm birth (PTB). Methods A multi-center prospective cohort study was conducted on 59 singleton pregnant...
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IL-17-Producing Cells in Tumor Immunity: Friends or Foes?

Kuen DS, Kim BS, Chung Y

IL-17 is produced by RAR-related orphan receptor gamma t (RORγt)-expressing cells including Th17 cells, subsets of γδT cells and innate lymphoid cells (ILCs). The biological significance of IL-17-producing cells is...
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Associations Between Circulating Interleukin-17 Levels and Systemic Lupus Erythematosus and Between Interleukin-17 Gene Polymorphisms and Disease Susceptibility: A Meta-analysis

Lee YH, Song GG

OBJECTIVE: To systematically investigate the relationship between circulating interleukin-17 (IL-17) levels and systemic lupus erythematosus (SLE) and associations between polymorphisms in IL17 genes and SLE susceptibility. METHODS: We performed a meta-analysis...
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Increased Innate Lymphoid Cell 3 and IL-17 Production in Mouse Lamina Propria Stimulated with Giardia lamblia

Lee HY, Park EA, Lee KJ, Lee KH, Park SJ

Innate lymphoid cells (ILCs) are key players during an immune response at the mucosal surfaces, such as lung, skin, and gastrointestinal tract. Giardia lamblia is an extracellular protozoan pathogen that...
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Recent medical therapy for psoriasis

Youn SW

Psoriasis is a chronic inflammatory disease. Medical therapy is the mainstay of the management of psoriasis, and the main target of psoriasis treatment is immunological dysregulation. Cyclosporine and methotrexate, the...
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N-acetyl-l-cysteine controls osteoclastogenesis through regulating Th17 differentiation and RANKL in rheumatoid arthritis

Kim HR, Kim KW, Kim BM, Lee KA, Lee SH

BACKGROUND/AIMS: This study aimed to determine the regulatory role of N-acetyl-l-cysteine (NAC), an antioxidant, in interleukin 17 (IL-17)-induced osteoclast differentiation in rheumatoid arthritis (RA). METHODS: After RA synovial fibroblasts were stimulated...
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Role of Salivary Immune Parameters in Patients With Primary Sjögren's Syndrome

Hung YH, Lee YH, Chen PP, Lin YZ, Lin CH, Yen JH

BACKGROUND: Several factors, including clinical manifestations and laboratory data, have been used to evaluate the disease activity of Sjögren's syndrome (SS). We investigated saliva indicators of disease activity in primary...
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A Case of Moderate Hidradenitis Suppurativa and Psoriasis Treated with Secukinumab

Giuseppe P, Nicola P, Valentina , Elena C, Salvatrice C, Rosario G, Rita BM

Hidradenitis suppurativa (HS) is a disorder of the apocrine gland causing a chronic, recurrent and painful inflammation. It is a disabilitating condition and, though many therapeutic options are available, the...
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Interleukin-17 Enhances Germinal Center Formation and Immunoglobulin G1 Production in Mice

Lee J, Lee SY, Kang CM, Jhun JY, Kim JH, Cho ML, Park SH, Kim HY, Kwok SK

OBJECTIVE: Interleukin (IL)-17 is a pro-inflammatory cytokine that has pleiotropic effects on multiple target cells and thereby contributes to the development of immune-mediated inflammatory disorders. However, the role of IL-17...
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