- Endoplasmic Reticulum Stress and Diabetes
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Kim MK, Park KG
- KMID: 2063543
- J Korean Endocr Soc.
- 2008 Feb;23(1):1-8.
- doi: 10.3803/jkes.2008.23.1.1
No abstract available. -
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- New Insights into the Role of Endoplasmic Reticulum Stress in Breast Cancer Metastasis
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Han CC, Wan FS
- KMID: 2429813
- J Breast Cancer.
- 2018 Dec;21(4):354-362.
- doi: 10.4048/jbc.2018.21.e51
Cellular stress severely disrupts endoplasmic reticulum (ER) function, leading to the abnormal accumulation of unfolded or misfolded proteins in the ER and subsequent development of endoplasmic reticulum stress (ERS). To... -
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- Endoplasmic Reticulum Stress Responses and Apoptosis
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Song CH
- KMID: 1434748
- J Bacteriol Virol.
- 2012 Sep;42(3):196-202.
- doi: 10.4167/jbv.2012.42.3.196
The endoplasmic reticulum (ER) plays a crucial role in various cellular activities and cell survival. Almost all of the resident proteins usually enter the ER, and are modified with N-linked... -
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- Nuclear Receptors Resolve Endoplasmic Reticulum Stress to Improve Hepatic Insulin Resistance
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Lee JM
- KMID: 2368524
- Diabetes Metab J.
- 2017 Feb;41(1):10-19.
- doi: 10.4093/dmj.2017.41.1.10
Chronic endoplasmic reticulum (ER) stress culminating in proteotoxicity contributes to the development of insulin resistance and progression to type 2 diabetes mellitus. Pharmacologic interventions targeting several different nuclear receptors have... -
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- Endoplasmic Reticulum Stress and the Related Signaling Networks in Severe Asthma
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Kim SR, Lee YC
- KMID: 2365538
- Allergy Asthma Immunol Res.
- 2015 Mar;7(2):106-117.
- doi: 10.4168/aair.2015.7.2.106
The endoplasmic reticulum (ER) is a specialized organelle that plays a central role in biosynthesis, correct protein folding, and posttranslational modifications of secretory and membrane proteins. Loss of homeostasis in... -
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- Endoplasmic reticulum stress in periimplantation embryos
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Michalak M, Gye MC
- KMID: 1800419
- Clin Exp Reprod Med.
- 2015 Mar;42(1):1-7.
- doi: 10.5653/cerm.2015.42.1.1
Stress coping mechanisms are critical to minimize or overcome damage caused by ever changing environmental conditions. They are designed to promote cell survival. The unfolded protein response (UPR) pathway is... -
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- Role of Endoplasmic Reticulum Stress in Rheumatoid Arthritis Pathogenesis
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Park YJ, Yoo SA, Kim WU
- KMID: 1796908
- J Korean Med Sci.
- 2014 Jan;29(1):2-11.
- doi: 10.3346/jkms.2014.29.1.2
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by abnormal proliferation of synoviocytes, leukocyte infiltration, and angiogenesis. The endoplasmic reticulum (ER) is the site of biosynthesis for all secreted... -
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- Emodin exerts protective effect against palmitic acid-induced endoplasmic reticulum stress in HepG2 cells
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Thomas SS, Park S, Cha YS, Kim KA
- KMID: 2444941
- J Nutr Health.
- 2019 Apr;52(2):176-184.
- doi: 10.4163/jnh.2019.52.2.176
PURPOSE: Protein overloading in the endoplasmic reticulum (ER) leads to endoplasmic reticulum stress, which exacerbates various disease conditions. Emodin, an anthraquinone compound, is known to have several health benefits. The... -
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- Characterization of Endoplasmic Reticulum Stress and Apoptosis in Macrophages Infected with Mycobacterium tuberculosis Isolates from Korea Patients
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Lee JH, Lim YJ, Choi JA, Han JY, Cho SH, Oh SM, Song CH
- KMID: 2068736
- J Bacteriol Virol.
- 2015 Sep;45(3):215-227.
- doi: 10.4167/jbv.2015.45.3.215
Apoptosis is an important host defense mechanism against mycobacterial infection. Recent reports suggest that links between apoptosis and endoplasmic reticulum (ER) stress are critical for the regulation of mycobacterial survival;... -
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- High-concentration Epigallocatechin Gallate Treatment Causes Endoplasmic Reticulum Stress-mediated Cell Death in HepG2 Cells
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Ahn JI, Jeong KJ, Ko MJ, Shin HJ, Chung HJ, Jeong HS
- KMID: 2053228
- Genomics Inform.
- 2009 Jun;7(2):97-106.
Epigallocatechin gallate (EGCG), a well-known antioxidant molecule, has been reported to cause hepatotoxicity when used in excess. However, the mechanism underlying EGCG-induced hepatotoxicity is still unclear. To better understand the... -
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- Blockade of Autophagy Aggravates Endoplasmic Reticulum Stress and Improves Paclitaxel Cytotoxicity in Human Cervical Cancer Cells
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Xu L, Liu JH, Zhang J, Zhang N, Wang ZH
- KMID: 2132811
- Cancer Res Treat.
- 2015 Apr;47(2):313-321.
- doi: 10.4143/crt.2013.222
PURPOSE: Autophagy is one of the ways to degrade unfolded proteins after endoplasmic reticulum (ER) stress. The purpose of this study is to determine whether a blockade of autophagy leads... -
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- Reactive oxygen species-mediated unfolded protein response pathways in preimplantation embryos
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Ali I, Shah SZ, Jin Y, Li ZS, Ullah O, Fang NZ
- KMID: 2412581
- J Vet Sci.
- 2017 Mar;18(1):1-9.
- doi: 10.4142/jvs.2017.18.1.1
Excessive production of reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress-mediated responses are critical to embryonic development in the challenging in vitro environment. ROS production increases during early embryonic... -
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- Effect of exercise and diet intervention on endoplasmic reticulum (ER) stress in rat skeletal muscle and adipose tissue
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Kim GC, Park KS, Kim HK, Kim KH
- KMID: 2268736
- Korean J Nutr.
- 2012 Oct;45(5):420-428.
- doi: 10.4163/kjn.2012.45.5.420
The purpose of this study is to investigate the effects of eight weeks high fat intake and regular exercise in skeletal muscle and adipose tissue for Endoplasmic Reticulum (ER) stress... -
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- Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease
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Kim YJ, Chang SY, Ko HJ
- KMID: 2284876
- Intest Res.
- 2015 Apr;13(2):105-111.
- doi: 10.5217/ir.2015.13.2.105
Immature myeloid cells, also known as myeloid-derived suppressor cells (MDSCs), include neutrophilic and monocytic myeloid cells, and are found in inflammatory loci and secondary lymphoid organs in mice with intestinal... -
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- Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic beta-cells
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Quan W, Lim YM, Lee MS
- KMID: 1120126
- Exp Mol Med.
- 2012 Feb;44(2):81-88.
- doi: 10.3858/emm.2012.44.2.030
Type 2 diabetes mellitus is characterized by insulin resistance and failure of pancreatic beta-cells producing insulin. Autophagy plays a crucial role in cellular homeostasis through degradation and recycling of organelles... -
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- Endoplasmic Reticulum Stress: Implications for Neuropsychiatric Disorders
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Muneer A, Shamsher Khan RM
- KMID: 2432250
- Chonnam Med J.
- 2019 Jan;55(1):8-19.
- doi: 10.4068/cmj.2019.55.1.8
The Endoplasmic reticulum (ER), an indispensable sub-cellular component of the eukaryotic cell carries out essential functions, is critical to the survival of the organism. The chaperone proteins and the folding... -
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- Association between p53 Expression and Amount of Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer
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Lee M, Park IA, Heo SH, Kim YA, Gong G, Lee HJ
- KMID: 2449341
- J Pathol Transl Med.
- 2019 May;53(3):180-187.
- doi: 10.4132/jptm.2019.02.08
BACKGROUND: Most triple-negative breast cancers (TNBCs) have a high histologic grade, are associated with high endoplasmic stress, and possess a high frequency of TP53 mutations. TP53 missense mutations lead to... -
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- Involvement of Endoplasmic Reticulum Stress Response in Orofacial Inflammatory Pain
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Yang ES, Bae JY, Kim TH, Kim YS, Suk K, Bae YC
- KMID: 2165542
- Exp Neurobiol.
- 2014 Dec;23(4):372-380.
- doi: 10.5607/en.2014.23.4.372
Endoplasmic reticulum (ER) stress is involved in many neurological diseases and inflammatory responses. Inflammatory mediators induce neuronal damage and trigger the neuropathic or inflammatory pain. But there is very little... -
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- Inhibition of ER Stress by 2-Aminopurine Treatment Modulates Cardiomyopathy in a Murine Chronic Chagas Disease Model
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Ayyappan J, lizardo K, Wang S, Yurkow E, Nagajyothi JF
- KMID: 2455094
- Biomol Ther.
- 2019 Jul;27(4):386-394.
- doi: 10.4062/biomolther.2018.193
Trypanosoma cruzi infection results in debilitating cardiomyopathy, which is a major cause of mortality and morbidity in the endemic regions of Chagas disease (CD). The pathogenesis of Chagasic cardiomyopathy (CCM)... -
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- Involvement of Endoplasmic Reticulum Stress Response in the Neuronal Differentiation
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Cho YM, Jang YS, Jang YM, Seo JY, Kim HS, Lee JH, Jeong SW, Kim IK, Kwon OJ
- KMID: 1512888
- Korean J Physiol Pharmacol.
- 2007 Dec;11(6):239-246.
Expressions of endoplasmic reticulum stress response (ERSR) genes were examined during the neuronal differentiation of rat fetal cortical precursor cells (rCPC) and rat pheochromocytoma PC12 cells. When rCPC were differentiated... -
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