J Korean Thyroid Assoc.  2013 Nov;6(2):96-100. 10.11106/jkta.2013.6.2.96.

Interactions between Immune Cells and Tumor Cells

• Cho SW

• KMID: 1845379
• DOI: http://doi.org/10.11106/jkta.2013.6.2.96

Abstract

Tumor microenvironment is defined as a heterogeneous complex composed of cancer cells, vascular endothelial cells, fibroblasts, and diverse immune cells. Cancer immunology is the study of interactions between the immune system and cancer cells which is applied to develop therapeutic strategies for human cancers. This review focused on tumor promoting myeloid derived cells such as tumor associated macrophages (TAM) and myeloid derived suppressor cells (MDSC) and their therapeutic applications.

Keyword

Tumor microenvironment; Tumor associated macrophages (TAM); Myeloid derived suppressor cells (MDSC); Cancer immunology

MeSH Terms

Allergy and Immunology
Endothelial Cells
Fibroblasts
Humans
Immune System
Macrophages
Tumor Microenvironment

Figure

• 

  Fig. 1. Macrophage activation and polarization. “Classically activated” M1 macrophages are activated by TNF, IFN γ or bacterial products such as microbial lipopolysaccharide (LPS), express high levels of IL12, IL–23, TNF, IL–1 or CXCL10 and low levels of IL10. By contrast, “alternatively activated” M2 macrophages are activated by IL4, IL10, IL13, M–CSF or glucocorticoid hormones, express high levels of IL10, IL–13, IL–4, CCL2, scavenger receptor-A or mannose receptor and low levels of IL12. Functionally, M1 macrophages are microbicidal or tumoricidal and M2 macrophages play a role in cell clearance/wound healing or tumor promotions.

Reference

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