Int J Stem Cells.  2025 Feb;18(1):1-11. 10.15283/ijsc23107.

Immune-Epithelial Cell Interactions during Epidermal Regeneration, Repair, and Inflammatory Diseases

Affiliations
  • 1Institute for Quantitative Health Science and Engineering (IQ), Michigan State University, East Lansing, MI, USA
  • 2Cell and Molecular Biology Program, College of Natural Science, Michigan State University, East Lansing, MI, USA
  • 3Division of Dermatology, Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI, USA
  • 4Department of Pharmacology and Toxicology, College of Human Medicine, Michigan State University, East Lansing, MI, USA

Abstract

The multiple layers of the skin cover and protect our entire body. Among the skin layers, the epidermis is in direct contact with the outer environment and serves as the first line of defense. The epidermis functions as a physical and immunological barrier. To maintain barrier function, the epidermis continually regenerates and repairs itself when injured. Interactions between tissue-resident immune cells and epithelial cells are essential to sustain epidermal regeneration and repair. In this review, we will dissect the crosstalk between epithelial cells and specific immune cell populations located in the epidermis during homeostasis and wound repair. In addition, we will analyze the contribution of dysregulated immune-epithelial interactions in chronic inflammatory diseases.

Keyword

Epidermis; Keratinocytes; Dendritic cells; Cell communication; Wound healing; Skin diseases
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