- Antitumor effect of TW-37, a BH3 mimetic in human oral cancer
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Ahn CH, Lee WW, Jung YC, Shin JA, Hong KO, Choi S, Swarup N, Kim J, Ahn MH, Jung M, Cho SD, Jin B
- KMID: 2470017
- Lab Anim Res.
- 2019 Dec;35(4):194-201.
- doi: 10.1186/s42826-019-0028-7
TW-37 is a small molecule B cell lymphoma-2 (Bcl-2) homology 3 mimetic with potential anticancer activities. However, the in vivo anti-cancer effect of TW-37 in human oral cancer has not... -
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- Granulocytic Sarcoma of the Sciatic Nerve Manifested as Relapse of Acute Myeloid Leukemia: A Case Report
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Lee SE, Chong Y, Song SW, Park J
- KMID: 2442524
- J Korean Soc Radiol.
- 2019 Mar;80(2):339-344.
- doi: 10.3348/jksr.2019.80.2.339
Granulocytic sarcoma is a form of extramedullary involvement of primitive myeloid cells. A 69-year-old male patient, with history of acute myeloid leukemia (AML) in remission state for 4 years, presented... -
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- Pseudo-Chediak-Higashi granules in myeloid cells in therapy-related AML with RUNX1-RUNX1T1
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Cho SR, Park JS
- KMID: 2429316
- Blood Res.
- 2018 Sep;53(3):188-188.
- doi: 10.5045/br.2018.53.3.188
No abstract available. -
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- Association of Chemokines and Chemokine Receptor Expression with Monocytic-Myeloid-Derived Suppressor Cells during Tumor Progression
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Seo EH, Namgung JH, Oh CS, Kim SH, Lee SH
- KMID: 2414557
- Immune Netw.
- 2018 Jun;18(3):e23.
- doi: 10.4110/in.2018.18.e23
Myeloid-derived suppressor cells (MDSCs) are highly immunosuppressive myeloid cells that show increased expression in cancer patients; however, the molecular mechanisms underlying their generation and function are unclear. Whereas granulocytic-MDSCs correlate... -
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- Out-sourcing for Trans-presentation: Assessing T Cell Intrinsic and Extrinsic IL-15 Expression with Il15 Gene Reporter Mice
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Park JY, Ligons DL, Park JH
- KMID: 2404895
- Immune Netw.
- 2018 Feb;18(1):e13.
- doi: 10.4110/in.2018.18.e13
IL-15 is a cytokine of the common γ-chain family that is critical for natural killer (NK), invariant natural killer T (iNKT), and CD8 memory T cell development and homeostasis. The... -
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- Control of Innate and Adaptive Lymphocytes by the RAR-Retinoic Acid Axis
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Kim CH
- KMID: 2404888
- Immune Netw.
- 2018 Feb;18(1):e1.
- doi: 10.4110/in.2018.18.e1
Lymphocytes, such as T cells, B cells, and innate lymphoid cells (ILCs), play central roles in regulating immune responses. Retinoic acids (RAs) are vitamin A metabolites, produced and metabolized by... -
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- Role of inflammasomes in inflammatory autoimmune rheumatic diseases
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Yi YS
- KMID: 2398550
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):1-15.
- doi: 10.4196/kjpp.2018.22.1.1
Inflammasomes are intracellular multiprotein complexes that coordinate anti-pathogenic host defense during inflammatory responses in myeloid cells, especially macrophages. Inflammasome activation leads to activation of caspase-1, resulting in the induction of... -
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- Neutrophilic Leukemoid Reaction Associated with Malignancy Initially Suspected as Chronic Neutrophilic Leukemia
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So MK, Park S, Mun YC, Seong CM, Huh HJ, Huh J
- KMID: 2389662
- Lab Med Online.
- 2017 Oct;7(4):206-210.
- doi: 10.3343/lmo.2017.7.4.206
Although neutrophilia can manifest from various causes, it is important to be able to distinguish chronic neutrophilic leukemia (CNL) from neutrophilic leukemoid reactions (NLR). In this paper, we describe four... -
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- IL-32-induced Inflammatory Cytokines Are Selectively Suppressed by α1-antitrypsin in Mouse Bone Marrow Cells
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Lee S, Choi DK, Kwak A, Kim S, Nguyen TT, Gil G, Kim E, Yoo KH, Kim IA, Lee Y, Jhun H, Chan ED, Bai X, Kim H, Kim YS, Kim S
- KMID: 2376869
- Immune Netw.
- 2017 Apr;17(2):116-120.
- doi: 10.4110/in.2017.17.2.116
The induction of interleukin (IL)-32 in bone marrow (BM) inflammation is crucial in graft versus host disease (GvHD) that is a common side effect of allogeneic BM transplantation. Clinical trials... -
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- Genetic Predisposition of Polymorphisms in HMGB1-Related Genes to Breast Cancer Prognosis in Korean Women
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Lee J, Choi J, Chung S, Park J, Kim JE, Sung H, Han W, Lee JW, Park SK, Kim MK, Ahn SH, Noh DY, Yoo KY, Kang D, Choi JY
- KMID: 2379396
- J Breast Cancer.
- 2017 Mar;20(1):27-34.
- doi: 10.4048/jbc.2017.20.1.27
PURPOSE: The high mobility group box 1 (HMGB1) protein has roles in apoptosis and immune responses by acting as a ligand for receptor for advanced glycation end products (RAGE), Toll-like... -
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- A Case of Malignancy-associated Histiocytoid Sweet Syndrome in a Patient with AML
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Seo JW, Kim TH, Choi SH, Ha SM, Song KH, Kim KH
- KMID: 2371085
- Korean J Dermatol.
- 2017 Feb;55(2):124-128.
Sweet syndrome is a disorder characterized by painful, erythematous, cutaneous plaques and nodules of rapid onset accompanied by fever, leukocytosis, and neutrophilia. We encountered a case of a recurrent histiocytoid... -
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- A Case of Leukemia Cutis in a Patient with Primary Myelofibrosis
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Kim YW, Kim JG, Kim BS, Choi JH, Shin DH, Choi JS
- KMID: 2368893
- Korean J Dermatol.
- 2016 Dec;54(10):803-806.
Primary myelofibrosis (PMF) is a chronic myeloproliferative disorder that is characterized by clonal proliferation of myeloid cells in the bone marrow. PMF should be distinguished from other chronic myeloproliferative neoplasms.... -
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- Induction of Nerve Injury-Induced Protein 1 (Ninjurin 1) in Myeloid Cells in Rat Brain after Transient Focal Cerebral Ischemia
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Lee HK, Lee H, Luo L, Lee JK
- KMID: 2352875
- Exp Neurobiol.
- 2016 Apr;25(2):64-71.
- doi: 10.5607/en.2016.25.2.64
Nerve injury-induced protein-1 (Ninjurin-1, Ninj1) was initially identified as a novel adhesion molecule in rat sciatic nerve and to be up-regulated in neurons and Schwann cells of distal nerve segments... -
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- A Case of Chronic Myeloid Leukemia with Multiple Chloromas Treated Successfully with Dasatinib
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Jang WY, Choi SM, Park MS, Ahn BC, Heo MH, Kim JY, Kwon KY, Do YR
- KMID: 2224174
- Keimyung Med J.
- 2015 Dec;34(2):120-126.
- doi: 10.0000/kmj.2015.34.2.120
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of the primitive hematopoietic stem cells. CML is characterized by the overproduction of myeloid cells, which results in marked splenomegaly and... -
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- A New Triggering Receptor Expressed on Myeloid Cells (TREM) Family Member, TLT-6, is Involved in Activation and Proliferation of Macrophages
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Won KJ, Park SW, Lee S, Kong IK, Chae JI, Kim B, Lee EJ, Kim DK
- KMID: 2150852
- Immune Netw.
- 2015 Oct;15(5):232-240.
- doi: 10.4110/in.2015.15.5.232
The triggering receptor expressed on myeloid cells (TREM) family, which is abundantly expressed in myeloid lineage cells, plays a pivotal role in innate and adaptive immune response. In this study,... -
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- Apoptosis: role in myeloid cell development
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Sarvothaman S, Undi RB, Pasupuleti SR, Gutti U, Gutti RK
- KMID: 2172770
- Blood Res.
- 2015 Jun;50(2):73-79.
- doi: 10.5045/br.2015.50.2.73
Hematopoiesis is the process that generates blood cells in an organism from the pluripotent stem cells. Hematopoietic stem cells are characterized by their ability to undergo self-renewal and differentiation. The... -
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- Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease
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Kim YJ, Chang SY, Ko HJ
- KMID: 2284876
- Intest Res.
- 2015 Apr;13(2):105-111.
- doi: 10.5217/ir.2015.13.2.105
Immature myeloid cells, also known as myeloid-derived suppressor cells (MDSCs), include neutrophilic and monocytic myeloid cells, and are found in inflammatory loci and secondary lymphoid organs in mice with intestinal... -
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- Pathogenesis of myelodysplastic syndromes: an overview of molecular and non-molecular aspects of the disease
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Visconte V, Tiu RV, Rogers HJ
- KMID: 2270678
- Blood Res.
- 2014 Dec;49(4):216-227.
- doi: 10.5045/br.2014.49.4.216
Myelodysplastic syndromes (MDS) are a group of clonal disorders arising from hematopoietic stem cells generally characterized by inefficient hematopoiesis, dysplasia in one or more myeloid cell lineages, and variable degrees... -
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- 5-aminoimidazole-4-carboxamide Riboside Induces Apoptosis Through AMP-activated Protein Kinase-independent and NADPH Oxidase-dependent Pathways
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Wi SM, Lee KY
- KMID: 2391720
- Immune Netw.
- 2014 Oct;14(5):241-248.
- doi: 10.4110/in.2014.14.5.241
It is debatable whether AMP-activated protein kinase (AMPK) activation is involved in anti-apoptotic or pro-apoptotic signaling. AICAR treatment increases AMPK-alpha1 phosphorylation, decreases intracellular reactive oxygen species (ROS) levels, and significantly... -
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- DICAM-mediated Inhibition of Type 1 Interferon System during Macrophage Differentiation of THP-1 Cells
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Kim BY, Park I, Jung YK, Han MS, Kim GW, Han SW
- KMID: 2297523
- J Rheum Dis.
- 2014 Jun;21(3):122-131.
- doi: 10.4078/jrd.2014.21.3.122
OBJECTIVE: We have previously shown that DICAM inhibits LPS-mediated macrophage differentiation. However, less is known about the exact action mechanisms of DICAM on the macrophage function and differentiation. METHODS: To induce... -
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