Nucl Med Mol Imaging.  2012 Jun;46(2):119-124.

Myeloid Sarcoma and Acute Myelomonocytic Leukemia in an Adolescent with Tetrasomy 8: Staging with 18F-FDG PET/CT

• Makis W
• Rakheja R
• Lavoie J
• Hickeson M

Abstract

Tetrasomy 8 is a relatively rare chromosomal abnormality that has been reported in only 33 cases in hematologic disorders. It is known for its association with aggressive acute myeloid leukemia (AML) and myeloid sarcoma and is considered a very poor prognostic factor. Myeloid sarcoma is a rare hematologic malignancy characterized by tumor masses consisting of immature myeloid cells, presenting at an extramedullary site. We present a case of a 17-year-old boy referred for an 18F-FDG PET/CT for the evaluation of pleural masses and spinal bone lesions seen on CT, after presenting with a 4 month history of chest pain. The PET/CT revealed extensive FDG-avid extramedullary disease in the soft tissues of the chest, abdomen, and pelvis, which were biopsy-proven to be myeloid sarcoma, as well as extensive intramedullary disease biopsy proven to be AML. This is the first report of the use of 18F-FDG PET/CT to stage a subset of aggressive AML and myeloid sarcoma in a patient with an associated chromosomal abnormality (tetrasomy 8).

Keyword

Tetrasomy 8; Extramedullary AML; Myeloid sarcoma; Granulocytic sarcoma; Fluorodeoxyglucose; FDG; PET/CT

MeSH Terms

Abdomen
Adolescent
Biopsy
Chest Pain
Chromosome Aberrations
Fluorodeoxyglucose F18
Hematologic Neoplasms
Humans
Leukemia, Myeloid, Acute
Leukemia, Myelomonocytic, Acute
Myeloid Cells
Pelvis
Sarcoma, Myeloid
Tetrasomy
Thorax
Fluorodeoxyglucose F18