Keimyung Med J.  2015 Dec;34(2):120-126. 10.0000/kmj.2015.34.2.120.

A Case of Chronic Myeloid Leukemia with Multiple Chloromas Treated Successfully with Dasatinib

• Jang WY
• Choi SM
• Park MS
• Ahn BC
• Heo MH
• Kim JY
• Kwon KY
• Do YR

• KMID: 2224174
• DOI: http://doi.org/10.0000/kmj.2015.34.2.120

Abstract

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of the primitive hematopoietic stem cells. CML is characterized by the overproduction of myeloid cells, which results in marked splenomegaly and leukocytosis. CML presented by multiple chloromas is extremely rare. Multiple chloromas in the skin and brain are quite rare as the initial presentation of CML. These rare manifestation should alert clinicians to include CML in the differential diagnosis of patients presenting with multiple non-pruritic skin nodules or neurologic symptoms. Dasatinib has promising therapeutic potential for managing intracranial leukemic disease. Here, we report the case of a patient who visited the hospital with multiple chloroma which is unusual presentation of CML, and treated with dasatinib successfully.

Keyword

Chloroma; Chronic myeloid leukemia; Dasatinib

MeSH Terms

Brain
Diagnosis, Differential
Hematopoietic Stem Cells
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*
Leukocytosis
Myeloid Cells
Myeloproliferative Disorders
Neurologic Manifestations
Sarcoma, Myeloid*
Skin
Splenomegaly
Dasatinib